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Oat consumption reduced intestinal fat deposition and improved health span in Caenorhabditis elegans model.

Gao C, Gao Z, Greenway FL, Burton JH, Johnson WD, Keenan MJ, Enright FM, Martin RJ, Chu Y, Zheng J - Nutr Res (2015)

Bottom Line: Oat feeding decreased intestinal fat deposition in N2, daf-16, or daf-16/daf-2 strains (P < .05); and glucose did not affect intestinal fat deposition response.Additional glucose further increased expression 1.5-fold of the 4 genes in N2 (P < .01), decreased the expression of all except cpt-1 in the daf-16 mutant, and reduced mRNA expression of the 4 genes in the daf-16/daf-2 mutant (P < .01).Oat consumption may be a beneficial dietary intervention for reducing fat accumulation, augmenting health span, and improving hyperglycemia-impaired lipid metabolism.

View Article: PubMed Central - PubMed

Affiliation: School of Nutrition and Food Sciences, Louisiana State University, Agricultural Center, Baton Rouge, LA, 70803.

No MeSH data available.


Related in: MedlinePlus

Oat feeding altered gene expression of ckr-1, gcy-8, cpt-1, and cpt-2 by Q-RT-PCR in C elegans.
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Figure 3: Oat feeding altered gene expression of ckr-1, gcy-8, cpt-1, and cpt-2 by Q-RT-PCR in C elegans.

Mentions: Oat feeding (0.5% and 1%) increased the mRNA expression of ckr-1, gcy-8, cpt-1, and cpt-2 in the C elegans N2, and sir-2.1– and daf-16–deficient strains (P < .01). Additional glucose further increased these mRNA expressions in N2 and sir-2.1. In the daf-16–deficient strain, ckr-1 and gcy-8 were increased after oat feeding (P < .01). All 4 genes tested were elevated in response to glucose treatment alone, and oat consumption in the presence of glucose significantly reduced mRNA expression of the 4 genes (P < .01). Oat feeding with glucose reduced mRNA expression of all 4 genes in daf-16/daf-2–deficient strains (P < .01). Oats (0.5%) plus glucose increased cpt-1 and cpt-2 (P < .01, Fig. 3).


Oat consumption reduced intestinal fat deposition and improved health span in Caenorhabditis elegans model.

Gao C, Gao Z, Greenway FL, Burton JH, Johnson WD, Keenan MJ, Enright FM, Martin RJ, Chu Y, Zheng J - Nutr Res (2015)

Oat feeding altered gene expression of ckr-1, gcy-8, cpt-1, and cpt-2 by Q-RT-PCR in C elegans.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4561582&req=5

Figure 3: Oat feeding altered gene expression of ckr-1, gcy-8, cpt-1, and cpt-2 by Q-RT-PCR in C elegans.
Mentions: Oat feeding (0.5% and 1%) increased the mRNA expression of ckr-1, gcy-8, cpt-1, and cpt-2 in the C elegans N2, and sir-2.1– and daf-16–deficient strains (P < .01). Additional glucose further increased these mRNA expressions in N2 and sir-2.1. In the daf-16–deficient strain, ckr-1 and gcy-8 were increased after oat feeding (P < .01). All 4 genes tested were elevated in response to glucose treatment alone, and oat consumption in the presence of glucose significantly reduced mRNA expression of the 4 genes (P < .01). Oat feeding with glucose reduced mRNA expression of all 4 genes in daf-16/daf-2–deficient strains (P < .01). Oats (0.5%) plus glucose increased cpt-1 and cpt-2 (P < .01, Fig. 3).

Bottom Line: Oat feeding decreased intestinal fat deposition in N2, daf-16, or daf-16/daf-2 strains (P < .05); and glucose did not affect intestinal fat deposition response.Additional glucose further increased expression 1.5-fold of the 4 genes in N2 (P < .01), decreased the expression of all except cpt-1 in the daf-16 mutant, and reduced mRNA expression of the 4 genes in the daf-16/daf-2 mutant (P < .01).Oat consumption may be a beneficial dietary intervention for reducing fat accumulation, augmenting health span, and improving hyperglycemia-impaired lipid metabolism.

View Article: PubMed Central - PubMed

Affiliation: School of Nutrition and Food Sciences, Louisiana State University, Agricultural Center, Baton Rouge, LA, 70803.

No MeSH data available.


Related in: MedlinePlus