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Oat consumption reduced intestinal fat deposition and improved health span in Caenorhabditis elegans model.

Gao C, Gao Z, Greenway FL, Burton JH, Johnson WD, Keenan MJ, Enright FM, Martin RJ, Chu Y, Zheng J - Nutr Res (2015)

Bottom Line: Oat feeding decreased intestinal fat deposition in N2, daf-16, or daf-16/daf-2 strains (P < .05); and glucose did not affect intestinal fat deposition response.Additional glucose further increased expression 1.5-fold of the 4 genes in N2 (P < .01), decreased the expression of all except cpt-1 in the daf-16 mutant, and reduced mRNA expression of the 4 genes in the daf-16/daf-2 mutant (P < .01).Oat consumption may be a beneficial dietary intervention for reducing fat accumulation, augmenting health span, and improving hyperglycemia-impaired lipid metabolism.

View Article: PubMed Central - PubMed

Affiliation: School of Nutrition and Food Sciences, Louisiana State University, Agricultural Center, Baton Rouge, LA, 70803.

No MeSH data available.


Related in: MedlinePlus

Oat feeding affected PPR, a surrogate marker of life span in C elegans.
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Figure 2: Oat feeding affected PPR, a surrogate marker of life span in C elegans.

Mentions: The PPRs declined in all groups as the C elegans aged. The oat treatment (0.5%, 1.0%, or 3%) increased the PPR in N2, daf-16, and sir-2.1 mutants (n = 24 C elegans/3 dishes, P < .001–.05). The PPR in N2 was increased in the oat group (0.5%, 1.0%, or 3%) in the presence of glucose (P < .005–.03). This increase persisted in the presence of glucose at a low dose in daf-16 or daf-16/daf-2 mutant (P < .05) (Fig. 2).


Oat consumption reduced intestinal fat deposition and improved health span in Caenorhabditis elegans model.

Gao C, Gao Z, Greenway FL, Burton JH, Johnson WD, Keenan MJ, Enright FM, Martin RJ, Chu Y, Zheng J - Nutr Res (2015)

Oat feeding affected PPR, a surrogate marker of life span in C elegans.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4561582&req=5

Figure 2: Oat feeding affected PPR, a surrogate marker of life span in C elegans.
Mentions: The PPRs declined in all groups as the C elegans aged. The oat treatment (0.5%, 1.0%, or 3%) increased the PPR in N2, daf-16, and sir-2.1 mutants (n = 24 C elegans/3 dishes, P < .001–.05). The PPR in N2 was increased in the oat group (0.5%, 1.0%, or 3%) in the presence of glucose (P < .005–.03). This increase persisted in the presence of glucose at a low dose in daf-16 or daf-16/daf-2 mutant (P < .05) (Fig. 2).

Bottom Line: Oat feeding decreased intestinal fat deposition in N2, daf-16, or daf-16/daf-2 strains (P < .05); and glucose did not affect intestinal fat deposition response.Additional glucose further increased expression 1.5-fold of the 4 genes in N2 (P < .01), decreased the expression of all except cpt-1 in the daf-16 mutant, and reduced mRNA expression of the 4 genes in the daf-16/daf-2 mutant (P < .01).Oat consumption may be a beneficial dietary intervention for reducing fat accumulation, augmenting health span, and improving hyperglycemia-impaired lipid metabolism.

View Article: PubMed Central - PubMed

Affiliation: School of Nutrition and Food Sciences, Louisiana State University, Agricultural Center, Baton Rouge, LA, 70803.

No MeSH data available.


Related in: MedlinePlus