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Oat consumption reduced intestinal fat deposition and improved health span in Caenorhabditis elegans model.

Gao C, Gao Z, Greenway FL, Burton JH, Johnson WD, Keenan MJ, Enright FM, Martin RJ, Chu Y, Zheng J - Nutr Res (2015)

Bottom Line: Oat feeding decreased intestinal fat deposition in N2, daf-16, or daf-16/daf-2 strains (P < .05); and glucose did not affect intestinal fat deposition response.Additional glucose further increased expression 1.5-fold of the 4 genes in N2 (P < .01), decreased the expression of all except cpt-1 in the daf-16 mutant, and reduced mRNA expression of the 4 genes in the daf-16/daf-2 mutant (P < .01).Oat consumption may be a beneficial dietary intervention for reducing fat accumulation, augmenting health span, and improving hyperglycemia-impaired lipid metabolism.

View Article: PubMed Central - PubMed

Affiliation: School of Nutrition and Food Sciences, Louisiana State University, Agricultural Center, Baton Rouge, LA, 70803.

No MeSH data available.


Related in: MedlinePlus

Nile Red staining of the IFD in C elegans after oat feeding in the absence or presence of 2% glucose.
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Figure 1: Nile Red staining of the IFD in C elegans after oat feeding in the absence or presence of 2% glucose.

Mentions: Oat feeding reduced IFD by 30% (0.5% and 1.0%) in the N2 strain (P < .05), and the addition of glucose to the oats increased IFD. Intestinal fat deposition decreased by 17% in response to 0.5% oats and 37% in response to 1.0% oats in the daf-16(mgDf50)I and increased with glucose treatment compared with the group that did not receive glucose (P < .05). The daf-16(mgDf50)I;daf-2(m65)III showed a similar dose-dependent reduction in IFD in response to oat feeding as well as in the presence of glucose (P < .05). Intestinal fat deposition was mildly lower following oat (0.5% and 1.0%) consumption in the sir-2.1(ok434)IV (P > .05) (Fig. 1).


Oat consumption reduced intestinal fat deposition and improved health span in Caenorhabditis elegans model.

Gao C, Gao Z, Greenway FL, Burton JH, Johnson WD, Keenan MJ, Enright FM, Martin RJ, Chu Y, Zheng J - Nutr Res (2015)

Nile Red staining of the IFD in C elegans after oat feeding in the absence or presence of 2% glucose.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4561582&req=5

Figure 1: Nile Red staining of the IFD in C elegans after oat feeding in the absence or presence of 2% glucose.
Mentions: Oat feeding reduced IFD by 30% (0.5% and 1.0%) in the N2 strain (P < .05), and the addition of glucose to the oats increased IFD. Intestinal fat deposition decreased by 17% in response to 0.5% oats and 37% in response to 1.0% oats in the daf-16(mgDf50)I and increased with glucose treatment compared with the group that did not receive glucose (P < .05). The daf-16(mgDf50)I;daf-2(m65)III showed a similar dose-dependent reduction in IFD in response to oat feeding as well as in the presence of glucose (P < .05). Intestinal fat deposition was mildly lower following oat (0.5% and 1.0%) consumption in the sir-2.1(ok434)IV (P > .05) (Fig. 1).

Bottom Line: Oat feeding decreased intestinal fat deposition in N2, daf-16, or daf-16/daf-2 strains (P < .05); and glucose did not affect intestinal fat deposition response.Additional glucose further increased expression 1.5-fold of the 4 genes in N2 (P < .01), decreased the expression of all except cpt-1 in the daf-16 mutant, and reduced mRNA expression of the 4 genes in the daf-16/daf-2 mutant (P < .01).Oat consumption may be a beneficial dietary intervention for reducing fat accumulation, augmenting health span, and improving hyperglycemia-impaired lipid metabolism.

View Article: PubMed Central - PubMed

Affiliation: School of Nutrition and Food Sciences, Louisiana State University, Agricultural Center, Baton Rouge, LA, 70803.

No MeSH data available.


Related in: MedlinePlus