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Amplification of Cellular Oncogenes in Solid Tumors.

Bagci O, Kurtgöz S - N Am J Med Sci (2015)

Bottom Line: Defining oncogene amplification is useful since it is used as a prognostic marker in clinical oncology nowadays, especially v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (HER2) targeted agents are used in breast cancer patients with high level of HER2 overexpression as a therapeutic approach.However, patients without HER2 overexpression do not appear to benefit from these agents.We have referred to PubMed and some databases to prepare this article.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Genetics, Suleyman Demirel University, School of Medicine, Isparta, Turkey.

ABSTRACT
The term gene amplification refers to an increase in copy number of a gene. Upregulation of gene expression through amplification is a general mechanism to increase gene dosage. Oncogene amplifications have been shown in solid human cancers and they are often associated with progression of cancer. Defining oncogene amplification is useful since it is used as a prognostic marker in clinical oncology nowadays, especially v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (HER2) targeted agents are used in breast cancer patients with high level of HER2 overexpression as a therapeutic approach. However, patients without HER2 overexpression do not appear to benefit from these agents. We concluded that determination of oncogene amplification in solid tumors is an important factor in treatment of human cancers with many unknowns. We have referred to PubMed and some databases to prepare this article.

No MeSH data available.


Related in: MedlinePlus

Two different amplification mechanisms for the MYCN oncogene[27]
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Figure 1: Two different amplification mechanisms for the MYCN oncogene[27]

Mentions: MYCN amplification in neuroblastoma constitutes an important model for oncogene amplification in tumorigenesis. In other neuronal tumors such as retinoblastoma, glioblastoma, small cell lung carcinoma, and astrocytoma carcinoma, however, MYCN amplification has been identified with a lower frequency.[161726] As demonstrated in Figure 1, amplified copies of oncogene MYCN can display an extrachromosomal structure as DMs and an intrachromosomal structure as HSRs.[161718262728]


Amplification of Cellular Oncogenes in Solid Tumors.

Bagci O, Kurtgöz S - N Am J Med Sci (2015)

Two different amplification mechanisms for the MYCN oncogene[27]
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4561439&req=5

Figure 1: Two different amplification mechanisms for the MYCN oncogene[27]
Mentions: MYCN amplification in neuroblastoma constitutes an important model for oncogene amplification in tumorigenesis. In other neuronal tumors such as retinoblastoma, glioblastoma, small cell lung carcinoma, and astrocytoma carcinoma, however, MYCN amplification has been identified with a lower frequency.[161726] As demonstrated in Figure 1, amplified copies of oncogene MYCN can display an extrachromosomal structure as DMs and an intrachromosomal structure as HSRs.[161718262728]

Bottom Line: Defining oncogene amplification is useful since it is used as a prognostic marker in clinical oncology nowadays, especially v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (HER2) targeted agents are used in breast cancer patients with high level of HER2 overexpression as a therapeutic approach.However, patients without HER2 overexpression do not appear to benefit from these agents.We have referred to PubMed and some databases to prepare this article.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Genetics, Suleyman Demirel University, School of Medicine, Isparta, Turkey.

ABSTRACT
The term gene amplification refers to an increase in copy number of a gene. Upregulation of gene expression through amplification is a general mechanism to increase gene dosage. Oncogene amplifications have been shown in solid human cancers and they are often associated with progression of cancer. Defining oncogene amplification is useful since it is used as a prognostic marker in clinical oncology nowadays, especially v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (HER2) targeted agents are used in breast cancer patients with high level of HER2 overexpression as a therapeutic approach. However, patients without HER2 overexpression do not appear to benefit from these agents. We concluded that determination of oncogene amplification in solid tumors is an important factor in treatment of human cancers with many unknowns. We have referred to PubMed and some databases to prepare this article.

No MeSH data available.


Related in: MedlinePlus