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Effects of Tongmai oral liquid in femoral ateriovenous fistula.

Su PL, Bao K, Peng HG, Mao W, Wang GS, Yang NZ, Geng WJ, Lin YQ, Jie XN - BMC Complement Altern Med (2015)

Bottom Line: Tissue adhesion of arteriovenous fistula with surrounding tissues was improved and fistula thrombosis was reduced by treatment with Tongmai oral liquid.NO concentration decreased to a different extent after vascular surgery.Tongmai oral liquid failed to regulate the equilibrium between NO and ET-1, but it improved blood flow of fistula stoma, as compared to control and Aspirin groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Nephrology, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), No.111 of Dade Road, Guangzhou, 510120, China. su_peiling_ok@126.com.

ABSTRACT

Background: This study was conducted to investigate the protective effect of Tongmai oral liquid on arteriovenous fistula function and to provide an effective method to promote fistula maturation.

Methods: Fifteen female and fifteen male SPF New Zealand rabbits were randomly allocated into 3 groups including control, Aspirin and Tongmai oral liquid groups. A side-to-side femoral arteriovenous fistula was established in each rabbit and then animals were treated with Aspirin or Tongmai oral liquid for 2 weeks. The concentrations of circulating ET-1 and NO were determined before and after operation (on preoperative day, operative day, post-D1, post-D3, post-D7 and post-D15), respectively. Blood flow of the fistula stoma and contralateral artery and vein was determined on the 15th postoperative day. Last, the fistula stoma was dissected to observe patency, thrombosis and adhesion with surrounding tissues.

Results: 28 rabbits survived during the surgical process and the following 15-day observational period. Tissue adhesion of arteriovenous fistula with surrounding tissues was improved and fistula thrombosis was reduced by treatment with Tongmai oral liquid. NO concentration decreased to a different extent after vascular surgery. Tongmai oral liquid failed to regulate the equilibrium between NO and ET-1, but it improved blood flow of fistula stoma, as compared to control and Aspirin groups. Blood flow of fistula stoma in the three groups was lower than that of the contralateral femoral artery.

Conclusions: Tongmai oral liquid improved the function of femoral ateriovenous fistula in the rabbit model by increasing blood flow and reducing thrombosis, probably not by regulating the dynamic equilibrium between NO and ET-1.

No MeSH data available.


Related in: MedlinePlus

Change of ET-1 concentrations during the observational period
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Fig2: Change of ET-1 concentrations during the observational period

Mentions: ET-1 levels were significantly different after surgery (F = 2.669, P = 0.025), especially in control group (F = 4.298, P = 0.004), while of no significance in both Aspirin group (F = 1.690, P = 0.156) and Tongmai group (F = 0.659, P = 0.656). The change of ET-1 concentration was not significant among the three groups (F = 3.179, P = 0.059). Interaction effect existed between different treatment methods and time points (F = 2.274, P = 0.018). After surgery, ET-1 levels in Tongmai and control groups increased to a peak on post-D1 and post-D7 respectively, and subsequently decreased in both groups, as demonstrated in Fig. 2.Fig. 2


Effects of Tongmai oral liquid in femoral ateriovenous fistula.

Su PL, Bao K, Peng HG, Mao W, Wang GS, Yang NZ, Geng WJ, Lin YQ, Jie XN - BMC Complement Altern Med (2015)

Change of ET-1 concentrations during the observational period
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4561428&req=5

Fig2: Change of ET-1 concentrations during the observational period
Mentions: ET-1 levels were significantly different after surgery (F = 2.669, P = 0.025), especially in control group (F = 4.298, P = 0.004), while of no significance in both Aspirin group (F = 1.690, P = 0.156) and Tongmai group (F = 0.659, P = 0.656). The change of ET-1 concentration was not significant among the three groups (F = 3.179, P = 0.059). Interaction effect existed between different treatment methods and time points (F = 2.274, P = 0.018). After surgery, ET-1 levels in Tongmai and control groups increased to a peak on post-D1 and post-D7 respectively, and subsequently decreased in both groups, as demonstrated in Fig. 2.Fig. 2

Bottom Line: Tissue adhesion of arteriovenous fistula with surrounding tissues was improved and fistula thrombosis was reduced by treatment with Tongmai oral liquid.NO concentration decreased to a different extent after vascular surgery.Tongmai oral liquid failed to regulate the equilibrium between NO and ET-1, but it improved blood flow of fistula stoma, as compared to control and Aspirin groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Nephrology, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), No.111 of Dade Road, Guangzhou, 510120, China. su_peiling_ok@126.com.

ABSTRACT

Background: This study was conducted to investigate the protective effect of Tongmai oral liquid on arteriovenous fistula function and to provide an effective method to promote fistula maturation.

Methods: Fifteen female and fifteen male SPF New Zealand rabbits were randomly allocated into 3 groups including control, Aspirin and Tongmai oral liquid groups. A side-to-side femoral arteriovenous fistula was established in each rabbit and then animals were treated with Aspirin or Tongmai oral liquid for 2 weeks. The concentrations of circulating ET-1 and NO were determined before and after operation (on preoperative day, operative day, post-D1, post-D3, post-D7 and post-D15), respectively. Blood flow of the fistula stoma and contralateral artery and vein was determined on the 15th postoperative day. Last, the fistula stoma was dissected to observe patency, thrombosis and adhesion with surrounding tissues.

Results: 28 rabbits survived during the surgical process and the following 15-day observational period. Tissue adhesion of arteriovenous fistula with surrounding tissues was improved and fistula thrombosis was reduced by treatment with Tongmai oral liquid. NO concentration decreased to a different extent after vascular surgery. Tongmai oral liquid failed to regulate the equilibrium between NO and ET-1, but it improved blood flow of fistula stoma, as compared to control and Aspirin groups. Blood flow of fistula stoma in the three groups was lower than that of the contralateral femoral artery.

Conclusions: Tongmai oral liquid improved the function of femoral ateriovenous fistula in the rabbit model by increasing blood flow and reducing thrombosis, probably not by regulating the dynamic equilibrium between NO and ET-1.

No MeSH data available.


Related in: MedlinePlus