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Frequency of Human Papilloma Virus (HPV) subtypes 31,33,35,39 and 45 among Yemeni women with cervical cancer.

Ahmed HG, Bensumaidea SH, Ashankyty IM - Infect. Agents Cancer (2015)

Bottom Line: A total of 200 (150 malignant and 50 benign) tissue samples were obtained from Yemeni women with cervical cancer, were investigated for the presence of HPV subtypes 31,33,35,39 and 45 by Polymerase Chain Reaction (PCR).The frequency of these HPV subtypes among Yemeni women with cervical cancer was 24 %.HPV 31, HPV 33, HPV35, HPV 39 and HPV45 were prevalent among Yemeni women with cervical cancer.

View Article: PubMed Central - PubMed

Affiliation: Molecular Diagnostics and Personalized Therapeutics Unit, University of Ha'il, Ha'il, Kingdom of Saudi Arabia ; Department of Pathology, College of Medicine, University of Ha'il, 2240 Hai'l, Kingdom of Saudi Arabia ; Department of Histopathology and Cytology, FMLS, University of Khartoum, Khartoum, Sudan.

ABSTRACT

Background: Identification of different HPV subtypes in unidentified communities provides sufficient information for screening and monitoring potential impact of a vaccination program. Therefore, the aim of this study was to screen for the presence of HPVs subtypes 31,33,35,39 and 45 among Yemeni women with Cervical Cancer.

Methodology: A total of 200 (150 malignant and 50 benign) tissue samples were obtained from Yemeni women with cervical cancer, were investigated for the presence of HPV subtypes 31,33,35,39 and 45 by Polymerase Chain Reaction (PCR).

Results: Of the 150 cervical cancer tissue specimens, HPV 31, HPV 33, HPV35, HPV 39 and HPV45 were identified in 10/150 (6.7 %), 6/150 (4 %), 6/150 (4 %), 5/150 (3.3 %) and 10/150 (6.7 %), respectively. The frequency of these HPV subtypes among Yemeni women with cervical cancer was 24 %.

Conclusion: HPV 31, HPV 33, HPV35, HPV 39 and HPV45 were prevalent among Yemeni women with cervical cancer.

No MeSH data available.


Related in: MedlinePlus

Description of HPV subtypes by Lesion type
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Fig1: Description of HPV subtypes by Lesion type

Mentions: In this study we investigated 200 formalin fixed paraffin wax tissue blocks obtained from patients previously presented with cervical lesions (150 were diagnosed with cervical cancer and 50 with benign cervical lesions). The ages of the studied group were ranging from 21 to 75 years with a mean age of 47 years. Of the 150 cervical cancer tissue specimens, HPV 31, HPV 33, HPV35, HPV 39 and HPV45were identified in 10/150 (6.7 %), 6/150 (4 %), 6/150 (4 %), 5/150 (3.3 %) and 10/150 (6.7 %), respectively. Of the 50 benign cervical lesions tissue specimens, HPV 31, HPV 33, HPV35, HPV 39 and HPV45 were identified in 1/50 (2 %), 1/50 (2 %), 1/50 (2 %), 0/50 (0 %) and 1/50 (2 %), respectively, as indicated in Fig. 1.Fig. 1


Frequency of Human Papilloma Virus (HPV) subtypes 31,33,35,39 and 45 among Yemeni women with cervical cancer.

Ahmed HG, Bensumaidea SH, Ashankyty IM - Infect. Agents Cancer (2015)

Description of HPV subtypes by Lesion type
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4561418&req=5

Fig1: Description of HPV subtypes by Lesion type
Mentions: In this study we investigated 200 formalin fixed paraffin wax tissue blocks obtained from patients previously presented with cervical lesions (150 were diagnosed with cervical cancer and 50 with benign cervical lesions). The ages of the studied group were ranging from 21 to 75 years with a mean age of 47 years. Of the 150 cervical cancer tissue specimens, HPV 31, HPV 33, HPV35, HPV 39 and HPV45were identified in 10/150 (6.7 %), 6/150 (4 %), 6/150 (4 %), 5/150 (3.3 %) and 10/150 (6.7 %), respectively. Of the 50 benign cervical lesions tissue specimens, HPV 31, HPV 33, HPV35, HPV 39 and HPV45 were identified in 1/50 (2 %), 1/50 (2 %), 1/50 (2 %), 0/50 (0 %) and 1/50 (2 %), respectively, as indicated in Fig. 1.Fig. 1

Bottom Line: A total of 200 (150 malignant and 50 benign) tissue samples were obtained from Yemeni women with cervical cancer, were investigated for the presence of HPV subtypes 31,33,35,39 and 45 by Polymerase Chain Reaction (PCR).The frequency of these HPV subtypes among Yemeni women with cervical cancer was 24 %.HPV 31, HPV 33, HPV35, HPV 39 and HPV45 were prevalent among Yemeni women with cervical cancer.

View Article: PubMed Central - PubMed

Affiliation: Molecular Diagnostics and Personalized Therapeutics Unit, University of Ha'il, Ha'il, Kingdom of Saudi Arabia ; Department of Pathology, College of Medicine, University of Ha'il, 2240 Hai'l, Kingdom of Saudi Arabia ; Department of Histopathology and Cytology, FMLS, University of Khartoum, Khartoum, Sudan.

ABSTRACT

Background: Identification of different HPV subtypes in unidentified communities provides sufficient information for screening and monitoring potential impact of a vaccination program. Therefore, the aim of this study was to screen for the presence of HPVs subtypes 31,33,35,39 and 45 among Yemeni women with Cervical Cancer.

Methodology: A total of 200 (150 malignant and 50 benign) tissue samples were obtained from Yemeni women with cervical cancer, were investigated for the presence of HPV subtypes 31,33,35,39 and 45 by Polymerase Chain Reaction (PCR).

Results: Of the 150 cervical cancer tissue specimens, HPV 31, HPV 33, HPV35, HPV 39 and HPV45 were identified in 10/150 (6.7 %), 6/150 (4 %), 6/150 (4 %), 5/150 (3.3 %) and 10/150 (6.7 %), respectively. The frequency of these HPV subtypes among Yemeni women with cervical cancer was 24 %.

Conclusion: HPV 31, HPV 33, HPV35, HPV 39 and HPV45 were prevalent among Yemeni women with cervical cancer.

No MeSH data available.


Related in: MedlinePlus