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Pre-treatment neutrophil-to-lymphocyte ratio is associated with neutrophil and T-cell infiltration and predicts clinical outcome in patients with glioblastoma.

Han S, Liu Y, Li Q, Li Z, Hou H, Wu A - BMC Cancer (2015)

Bottom Line: Markers of systemic inflammation are correlated with patient survival in various cancers.Despite the correlation between NLR and PLR (R = 0.509, P < 0.001), NLR was superior to PLR as a prognostic factor.Pre-treatment NLR is of prognostic significance independent of MGMT status and is superior to PLR as a prognostic factor.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, The First Hospital of China Medical University, Nanjing Street 155, Heping District, Shenyang, 110001, China. hansheng2001_x@aliyun.com.

ABSTRACT

Background: Markers of systemic inflammation are correlated with patient survival in various cancers. The prognostic value of neutrophil-to-lymphocyte ratio (NLR) was compared with that of platelet-to-lymphocyte ratio (PLR) in patients with glioblastoma. The association of NLR with neutrophil and T- cell infiltration was also explored.

Methods: A total of 152 patients with glioblastoma were retrospectively analyzed. Clinical information was obtained from electronic medical records. Kaplan-Meier analysis and the Cox proportional hazards models were used to examine the survival function of pre-treatment NLR and PLR in these glioblastoma patients. Neutrophil and CD3(+) T-cell infiltration was assessed by immunohistochemical staining of tissue microarray cores from glioblastomas.

Results: Pre-treatment NLR levels were significantly correlated with overall survival (OS) in glioblastoma patients (multivariate hazard ratio =1.050; 95% confidence interval, 1.003-1.100; P = 0.037). Despite the correlation between NLR and PLR (R = 0.509, P < 0.001), NLR was superior to PLR as a prognostic factor. High pre-treatment NLR (≥4 versus < 4) was significantly associated with high neutrophil infiltration and low CD3(+) T-cell infiltration into tumors, and predicted poor OS (mean, 10.6 vs. 17.9 months, P < 0.001).

Conclusions: Pre-treatment NLR is of prognostic significance independent of MGMT status and is superior to PLR as a prognostic factor. Our results demonstrate a correlation between elevated peripheral blood NLR levels and increased tumor neutrophil infiltration/decreased CD3(+) T-cell infiltration.

No MeSH data available.


Related in: MedlinePlus

Pre-treatment neutrophil-to-lymphocyte ratio (NLR) and prognosis. a, b Pre-treatment NLR levels and 1-year (a) and 2-year (b) survival rates. c, d Kaplan-Meier survival curves stratified by pre-treatment NLR levels. Survival time was significantly shorter among patients with NLR ≥4 (or >2.54) than among those with NLR <4 (or ≤2.54)
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Fig1: Pre-treatment neutrophil-to-lymphocyte ratio (NLR) and prognosis. a, b Pre-treatment NLR levels and 1-year (a) and 2-year (b) survival rates. c, d Kaplan-Meier survival curves stratified by pre-treatment NLR levels. Survival time was significantly shorter among patients with NLR ≥4 (or >2.54) than among those with NLR <4 (or ≤2.54)

Mentions: Next, we examined the survival function of pre-treatment NLR in glioblastoma patients. Univariate and multivariate Cox regression analyses showed that pre-treatment NLR was an independent predictor of OS (multivariate hazard ratio = 1.050, 95 % confidence interval 1.003–1.100, P = 0.037, Table 2). As shown in Fig. 1a and b, Patients with high NLR (≥4) had lower 1-year and 2-year survival rates than those with low NLR (<4). The OS of patients with high NLR (≥4) was also shorter than that of patients with low NLR (<4; mean 10.6 vs. 17.9 months, P < 0.001; Fig. 1c). When the median pre-treatment NLR (2.54) was used as the cutoff point, similar results were obtained (Fig. 1d).Table 2


Pre-treatment neutrophil-to-lymphocyte ratio is associated with neutrophil and T-cell infiltration and predicts clinical outcome in patients with glioblastoma.

Han S, Liu Y, Li Q, Li Z, Hou H, Wu A - BMC Cancer (2015)

Pre-treatment neutrophil-to-lymphocyte ratio (NLR) and prognosis. a, b Pre-treatment NLR levels and 1-year (a) and 2-year (b) survival rates. c, d Kaplan-Meier survival curves stratified by pre-treatment NLR levels. Survival time was significantly shorter among patients with NLR ≥4 (or >2.54) than among those with NLR <4 (or ≤2.54)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4559944&req=5

Fig1: Pre-treatment neutrophil-to-lymphocyte ratio (NLR) and prognosis. a, b Pre-treatment NLR levels and 1-year (a) and 2-year (b) survival rates. c, d Kaplan-Meier survival curves stratified by pre-treatment NLR levels. Survival time was significantly shorter among patients with NLR ≥4 (or >2.54) than among those with NLR <4 (or ≤2.54)
Mentions: Next, we examined the survival function of pre-treatment NLR in glioblastoma patients. Univariate and multivariate Cox regression analyses showed that pre-treatment NLR was an independent predictor of OS (multivariate hazard ratio = 1.050, 95 % confidence interval 1.003–1.100, P = 0.037, Table 2). As shown in Fig. 1a and b, Patients with high NLR (≥4) had lower 1-year and 2-year survival rates than those with low NLR (<4). The OS of patients with high NLR (≥4) was also shorter than that of patients with low NLR (<4; mean 10.6 vs. 17.9 months, P < 0.001; Fig. 1c). When the median pre-treatment NLR (2.54) was used as the cutoff point, similar results were obtained (Fig. 1d).Table 2

Bottom Line: Markers of systemic inflammation are correlated with patient survival in various cancers.Despite the correlation between NLR and PLR (R = 0.509, P < 0.001), NLR was superior to PLR as a prognostic factor.Pre-treatment NLR is of prognostic significance independent of MGMT status and is superior to PLR as a prognostic factor.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, The First Hospital of China Medical University, Nanjing Street 155, Heping District, Shenyang, 110001, China. hansheng2001_x@aliyun.com.

ABSTRACT

Background: Markers of systemic inflammation are correlated with patient survival in various cancers. The prognostic value of neutrophil-to-lymphocyte ratio (NLR) was compared with that of platelet-to-lymphocyte ratio (PLR) in patients with glioblastoma. The association of NLR with neutrophil and T- cell infiltration was also explored.

Methods: A total of 152 patients with glioblastoma were retrospectively analyzed. Clinical information was obtained from electronic medical records. Kaplan-Meier analysis and the Cox proportional hazards models were used to examine the survival function of pre-treatment NLR and PLR in these glioblastoma patients. Neutrophil and CD3(+) T-cell infiltration was assessed by immunohistochemical staining of tissue microarray cores from glioblastomas.

Results: Pre-treatment NLR levels were significantly correlated with overall survival (OS) in glioblastoma patients (multivariate hazard ratio =1.050; 95% confidence interval, 1.003-1.100; P = 0.037). Despite the correlation between NLR and PLR (R = 0.509, P < 0.001), NLR was superior to PLR as a prognostic factor. High pre-treatment NLR (≥4 versus < 4) was significantly associated with high neutrophil infiltration and low CD3(+) T-cell infiltration into tumors, and predicted poor OS (mean, 10.6 vs. 17.9 months, P < 0.001).

Conclusions: Pre-treatment NLR is of prognostic significance independent of MGMT status and is superior to PLR as a prognostic factor. Our results demonstrate a correlation between elevated peripheral blood NLR levels and increased tumor neutrophil infiltration/decreased CD3(+) T-cell infiltration.

No MeSH data available.


Related in: MedlinePlus