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Comparison of Multi-Echo Dixon Methods with Volume Interpolated Breath-Hold Gradient Echo Magnetic Resonance Imaging in Fat-Signal Fraction Quantification of Paravertebral Muscle.

Yoo YH, Kim HS, Lee YH, Yoon CS, Paek MY, Yoo H, Kannengiesser S, Chung TS, Song HT, Suh JS, Kim S - Korean J Radiol (2015)

Bottom Line: Lin's concordance correlation between the spectroscopic findings and all the imaging-based FFs were statistically significant (p < 0.001).FFs obtained from the T2*-corrected six-echo Dixon sequences showed a significantly better concordance with the spectroscopic data, with its concordance correlation coefficient being 0.99 and 0.98 (p < 0.001), as compared with two- or three-echo methods.T2*-corrected six-echo Dixon sequence would be a better option than two- or three-echo methods for noninvasive quantification of lumbar muscle fat quantification.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Korea.

ABSTRACT

Objective: To assess whether multi-echo Dixon magnetic resonance (MR) imaging with simultaneous T2* estimation and correction yields more accurate fat-signal fraction (FF) measurement of the lumbar paravertebral muscles, in comparison with non-T2*-corrected two-echo Dixon or T2*-corrected three-echo Dixon, using the FF measurements from single-voxel MR spectroscopy as the reference standard.

Materials and methods: Sixty patients with low back pain underwent MR imaging with a 1.5T scanner. FF mapping images automatically obtained using T2*-corrected Dixon technique with two (non-T2*-corrected), three, and six echoes, were compared with images from single-voxel MR spectroscopy at the paravertebral muscles on levels L4 through L5. FFs were measured directly by two radiologists, who independently drew the region of interest on the mapping images from the three sequences.

Results: A total of 117 spectroscopic measurements were performed either bilaterally (57 of 60 subjects) or unilaterally (3 of 60 subjects). The mean spectroscopic FF was 14.3 ± 11.7% (range, 1.9-63.7%). Interobserver agreement was excellent between the two radiologists. Lin's concordance correlation between the spectroscopic findings and all the imaging-based FFs were statistically significant (p < 0.001). FFs obtained from the T2*-corrected six-echo Dixon sequences showed a significantly better concordance with the spectroscopic data, with its concordance correlation coefficient being 0.99 and 0.98 (p < 0.001), as compared with two- or three-echo methods.

Conclusion: T2*-corrected six-echo Dixon sequence would be a better option than two- or three-echo methods for noninvasive quantification of lumbar muscle fat quantification.

No MeSH data available.


Related in: MedlinePlus

Bland-Altman plots for assessment of agreement of fat-signal fraction (FF) between MR spectroscopy (MRS) and mapping image measurements.Bland-Altman plot shows mean measurement bias with limits of agreement of FFs, obtained from FF maps using non-T2*-corrected two-echo volume interpolated breath-hold gradient-echo (VIBE-Dixon) sequence (Observer A, A-1; Observer B, B-1), T2*-corrected three-echo VIBE-Dixon sequence (Observer A, A-2; Observer B, B-2), and T2*-corrected six-echo VIBE-Dixon sequence (Observer A, A-3; Observer B, B-3) in relation to FFs measured with MRS. Narrow range of limits of agreement was seen in T2*-corrected six-echo VIBE-Dixon as compared with other sequences in each observer. FF % two-echo = FF obtained from non-T2*-corrected two-echo VIBE-Dixon sequence, FF % three-echo = FF obtained from T2*-corrected three-echo VIBE-Dixon sequence, FF % six-echo = FF obtained from T2*-corrected six-echo VIBE-Dixon sequence, FF % MRS = FF obtained from MR spectroscopy, SD = standard deviation
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Figure 4: Bland-Altman plots for assessment of agreement of fat-signal fraction (FF) between MR spectroscopy (MRS) and mapping image measurements.Bland-Altman plot shows mean measurement bias with limits of agreement of FFs, obtained from FF maps using non-T2*-corrected two-echo volume interpolated breath-hold gradient-echo (VIBE-Dixon) sequence (Observer A, A-1; Observer B, B-1), T2*-corrected three-echo VIBE-Dixon sequence (Observer A, A-2; Observer B, B-2), and T2*-corrected six-echo VIBE-Dixon sequence (Observer A, A-3; Observer B, B-3) in relation to FFs measured with MRS. Narrow range of limits of agreement was seen in T2*-corrected six-echo VIBE-Dixon as compared with other sequences in each observer. FF % two-echo = FF obtained from non-T2*-corrected two-echo VIBE-Dixon sequence, FF % three-echo = FF obtained from T2*-corrected three-echo VIBE-Dixon sequence, FF % six-echo = FF obtained from T2*-corrected six-echo VIBE-Dixon sequence, FF % MRS = FF obtained from MR spectroscopy, SD = standard deviation

Mentions: Figure 4 shows the mean measurement bias with corresponding limits of agreement for FFs obtained from three different VIBE-Dixon sequences and those from MRS. The mean measurement bias was -2.5% (range, -9.2% to 4.2%) for two-echo, -2.4% (range, -8.6% to 3.7%) for three-echo, and 0.2% (range, -2.8% to 3.3%) for six-echo methods as evaluated by observer A, and -2.6% (range, -9.0% to 3.9%) for two-echo, -3.1% (range, -9.4% to 3.3%) for three-echo, and 0.5% (range, -2.9% to 3.9%) for sixecho methods as evaluated by observer B. In the findings of each observer, the range of limits of agreement was very narrow for T2*-corrected six-echo VIBE-Dixon findings, in comparison with the other sequences.


Comparison of Multi-Echo Dixon Methods with Volume Interpolated Breath-Hold Gradient Echo Magnetic Resonance Imaging in Fat-Signal Fraction Quantification of Paravertebral Muscle.

Yoo YH, Kim HS, Lee YH, Yoon CS, Paek MY, Yoo H, Kannengiesser S, Chung TS, Song HT, Suh JS, Kim S - Korean J Radiol (2015)

Bland-Altman plots for assessment of agreement of fat-signal fraction (FF) between MR spectroscopy (MRS) and mapping image measurements.Bland-Altman plot shows mean measurement bias with limits of agreement of FFs, obtained from FF maps using non-T2*-corrected two-echo volume interpolated breath-hold gradient-echo (VIBE-Dixon) sequence (Observer A, A-1; Observer B, B-1), T2*-corrected three-echo VIBE-Dixon sequence (Observer A, A-2; Observer B, B-2), and T2*-corrected six-echo VIBE-Dixon sequence (Observer A, A-3; Observer B, B-3) in relation to FFs measured with MRS. Narrow range of limits of agreement was seen in T2*-corrected six-echo VIBE-Dixon as compared with other sequences in each observer. FF % two-echo = FF obtained from non-T2*-corrected two-echo VIBE-Dixon sequence, FF % three-echo = FF obtained from T2*-corrected three-echo VIBE-Dixon sequence, FF % six-echo = FF obtained from T2*-corrected six-echo VIBE-Dixon sequence, FF % MRS = FF obtained from MR spectroscopy, SD = standard deviation
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4559780&req=5

Figure 4: Bland-Altman plots for assessment of agreement of fat-signal fraction (FF) between MR spectroscopy (MRS) and mapping image measurements.Bland-Altman plot shows mean measurement bias with limits of agreement of FFs, obtained from FF maps using non-T2*-corrected two-echo volume interpolated breath-hold gradient-echo (VIBE-Dixon) sequence (Observer A, A-1; Observer B, B-1), T2*-corrected three-echo VIBE-Dixon sequence (Observer A, A-2; Observer B, B-2), and T2*-corrected six-echo VIBE-Dixon sequence (Observer A, A-3; Observer B, B-3) in relation to FFs measured with MRS. Narrow range of limits of agreement was seen in T2*-corrected six-echo VIBE-Dixon as compared with other sequences in each observer. FF % two-echo = FF obtained from non-T2*-corrected two-echo VIBE-Dixon sequence, FF % three-echo = FF obtained from T2*-corrected three-echo VIBE-Dixon sequence, FF % six-echo = FF obtained from T2*-corrected six-echo VIBE-Dixon sequence, FF % MRS = FF obtained from MR spectroscopy, SD = standard deviation
Mentions: Figure 4 shows the mean measurement bias with corresponding limits of agreement for FFs obtained from three different VIBE-Dixon sequences and those from MRS. The mean measurement bias was -2.5% (range, -9.2% to 4.2%) for two-echo, -2.4% (range, -8.6% to 3.7%) for three-echo, and 0.2% (range, -2.8% to 3.3%) for six-echo methods as evaluated by observer A, and -2.6% (range, -9.0% to 3.9%) for two-echo, -3.1% (range, -9.4% to 3.3%) for three-echo, and 0.5% (range, -2.9% to 3.9%) for sixecho methods as evaluated by observer B. In the findings of each observer, the range of limits of agreement was very narrow for T2*-corrected six-echo VIBE-Dixon findings, in comparison with the other sequences.

Bottom Line: Lin's concordance correlation between the spectroscopic findings and all the imaging-based FFs were statistically significant (p < 0.001).FFs obtained from the T2*-corrected six-echo Dixon sequences showed a significantly better concordance with the spectroscopic data, with its concordance correlation coefficient being 0.99 and 0.98 (p < 0.001), as compared with two- or three-echo methods.T2*-corrected six-echo Dixon sequence would be a better option than two- or three-echo methods for noninvasive quantification of lumbar muscle fat quantification.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Korea.

ABSTRACT

Objective: To assess whether multi-echo Dixon magnetic resonance (MR) imaging with simultaneous T2* estimation and correction yields more accurate fat-signal fraction (FF) measurement of the lumbar paravertebral muscles, in comparison with non-T2*-corrected two-echo Dixon or T2*-corrected three-echo Dixon, using the FF measurements from single-voxel MR spectroscopy as the reference standard.

Materials and methods: Sixty patients with low back pain underwent MR imaging with a 1.5T scanner. FF mapping images automatically obtained using T2*-corrected Dixon technique with two (non-T2*-corrected), three, and six echoes, were compared with images from single-voxel MR spectroscopy at the paravertebral muscles on levels L4 through L5. FFs were measured directly by two radiologists, who independently drew the region of interest on the mapping images from the three sequences.

Results: A total of 117 spectroscopic measurements were performed either bilaterally (57 of 60 subjects) or unilaterally (3 of 60 subjects). The mean spectroscopic FF was 14.3 ± 11.7% (range, 1.9-63.7%). Interobserver agreement was excellent between the two radiologists. Lin's concordance correlation between the spectroscopic findings and all the imaging-based FFs were statistically significant (p < 0.001). FFs obtained from the T2*-corrected six-echo Dixon sequences showed a significantly better concordance with the spectroscopic data, with its concordance correlation coefficient being 0.99 and 0.98 (p < 0.001), as compared with two- or three-echo methods.

Conclusion: T2*-corrected six-echo Dixon sequence would be a better option than two- or three-echo methods for noninvasive quantification of lumbar muscle fat quantification.

No MeSH data available.


Related in: MedlinePlus