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Single-fraction radiation therapy in patients with metastatic Merkel cell carcinoma.

Iyer JG, Parvathaneni U, Gooley T, Miller NJ, Markowitz E, Blom A, Lewis CW, Doumani RF, Parvathaneni K, Anderson A, Bestick A, Liao J, Kane G, Bhatia S, Paulson K, Nghiem P - Cancer Med (2015)

Bottom Line: Cytotoxic chemotherapy is associated with high response rates, but responses are seldom durable and toxicity is considerable.Clinically significant toxicity was seen in only two patients who had transient side effects.Use of SFRT in palliating MCC patients was associated with an excellent in field control rate and durable responses at treated sites, and with minimal toxicity.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine/Dermatology, University of Washington, Seattle, Washington.

No MeSH data available.


Related in: MedlinePlus

Flow diagram for 101 metastatic Merkel cell carcinoma lesions treated with single-fraction radiation therapy (SFRT). The diagram summarizes the available data used for the specified analyses and tables and figures in which those data are presented.
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fig01: Flow diagram for 101 metastatic Merkel cell carcinoma lesions treated with single-fraction radiation therapy (SFRT). The diagram summarizes the available data used for the specified analyses and tables and figures in which those data are presented.

Mentions: All patients (except those with superficial lesions treated with electrons) had a CT scan for RT planning and responses tracked via CT scan. Superficial lesions were tracked by measurement with a ruler, and/or digital photography. Toxicity was graded using the Common Terminology Criteria of Adverse Events v3.0. RTOG/EORTC late radiation morbidity scoring schema. Of the 93 tumors treated using SFRT, efficacy analysis was carried out on 92 tumors (see Fig.1). Response evaluation was by RECIST version 1.1 12, modified only in that pretreatment lesion size reported was the longest dimension of all tumors including lymph nodes. When lesions were grouped in extreme proximity, they were irradiated with a single-targeted dose of 8 Gy and their sizes were measured as a single lesion. Complete palliation for bone metastasis was defined as complete resolution of pain, which was the only presenting symptom for these patients.


Single-fraction radiation therapy in patients with metastatic Merkel cell carcinoma.

Iyer JG, Parvathaneni U, Gooley T, Miller NJ, Markowitz E, Blom A, Lewis CW, Doumani RF, Parvathaneni K, Anderson A, Bestick A, Liao J, Kane G, Bhatia S, Paulson K, Nghiem P - Cancer Med (2015)

Flow diagram for 101 metastatic Merkel cell carcinoma lesions treated with single-fraction radiation therapy (SFRT). The diagram summarizes the available data used for the specified analyses and tables and figures in which those data are presented.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4559027&req=5

fig01: Flow diagram for 101 metastatic Merkel cell carcinoma lesions treated with single-fraction radiation therapy (SFRT). The diagram summarizes the available data used for the specified analyses and tables and figures in which those data are presented.
Mentions: All patients (except those with superficial lesions treated with electrons) had a CT scan for RT planning and responses tracked via CT scan. Superficial lesions were tracked by measurement with a ruler, and/or digital photography. Toxicity was graded using the Common Terminology Criteria of Adverse Events v3.0. RTOG/EORTC late radiation morbidity scoring schema. Of the 93 tumors treated using SFRT, efficacy analysis was carried out on 92 tumors (see Fig.1). Response evaluation was by RECIST version 1.1 12, modified only in that pretreatment lesion size reported was the longest dimension of all tumors including lymph nodes. When lesions were grouped in extreme proximity, they were irradiated with a single-targeted dose of 8 Gy and their sizes were measured as a single lesion. Complete palliation for bone metastasis was defined as complete resolution of pain, which was the only presenting symptom for these patients.

Bottom Line: Cytotoxic chemotherapy is associated with high response rates, but responses are seldom durable and toxicity is considerable.Clinically significant toxicity was seen in only two patients who had transient side effects.Use of SFRT in palliating MCC patients was associated with an excellent in field control rate and durable responses at treated sites, and with minimal toxicity.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine/Dermatology, University of Washington, Seattle, Washington.

No MeSH data available.


Related in: MedlinePlus