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The DA antagonist tiapride impairs context-related extinction learning in a novel context without affecting renewal.

Lissek S, Glaubitz B, Wolf OT, Tegenthoff M - Front Behav Neurosci (2015)

Bottom Line: Groups did not differ in their level of ABA renewal.In ABA extinction, TIA showed reduced activation in dlPFC and OFC, hippocampus, and temporal regions.However, relating context to the appropriate association during recall does not appear to rely exclusively on DA signaling.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, BG University Hospital Bergmannsheil, Ruhr-University Bochum Bochum, Germany.

ABSTRACT
Renewal describes the recovery of an extinguished response if recall is tested in a context different from the extinction context. Behavioral studies demonstrated that attention to relevant context strengthens renewal. Neurotransmitters mediating attention and learning such as the dopaminergic (DA) system presumably modulate extinction learning and renewal. However, the role of DA for non-fear-based extinction learning and renewal in humans has not yet been investigated. This fMRI study investigated effects of DA-antagonism upon context-related extinction in a predictive learning task in which extinction occurred either in a novel (ABA) or an unchanged (AAA) context. The tiapride-treated group (TIA) showed significantly impaired ABA extinction learning and a significant within-group difference between ABA and AAA extinction, compared to placebo (PLAC). Groups did not differ in their level of ABA renewal. In ABA extinction, TIA showed reduced activation in dlPFC and OFC, hippocampus, and temporal regions. Across groups, activation in PFC and hippocampus correlated negatively with ABA extinction errors. Results suggest that in context-related extinction learning DA in PFC and hippocampus is involved in readjusting the cue-outcome relationship in the presence of a novel context. However, relating context to the appropriate association during recall does not appear to rely exclusively on DA signaling.

No MeSH data available.


Related in: MedlinePlus

Predictive learning task. (A) Example of a trial during acquisition of the task. Participants learned to predict whether certain kinds of food, eaten in a certain restaurant, would cause a stomach ache or not. After an intertrial interval of 5–9 s the stimulus was presented in its context for 3 s, then a question was superimposed on the screen “Do you expect your patient to get a stomach ache?” for maximum 4 s response time. Feedback was shown for 2 s, providing the correct answer, e.g., “The patient does not have a stomach ache.” (B) Design of the predictive learning task. In condition AAA, extinction occurs in the same context as acquisition. In condition ABA, extinction occurs in a context different from that during acquisition. In both conditions, the final test for the renewal effect is performed in the context of acquisition. (C) Food images used as stimuli.
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Figure 1: Predictive learning task. (A) Example of a trial during acquisition of the task. Participants learned to predict whether certain kinds of food, eaten in a certain restaurant, would cause a stomach ache or not. After an intertrial interval of 5–9 s the stimulus was presented in its context for 3 s, then a question was superimposed on the screen “Do you expect your patient to get a stomach ache?” for maximum 4 s response time. Feedback was shown for 2 s, providing the correct answer, e.g., “The patient does not have a stomach ache.” (B) Design of the predictive learning task. In condition AAA, extinction occurs in the same context as acquisition. In condition ABA, extinction occurs in a context different from that during acquisition. In both conditions, the final test for the renewal effect is performed in the context of acquisition. (C) Food images used as stimuli.

Mentions: In the predictive learning task, participants were asked to put themselves in the position of a physician and predict whether various articles of food served in different restaurants would lead to the aversive consequence of a stomach ache in their patient. The learning process consisted of the three successive phases of (a) acquisition of associations, (b) extinction, and (c) recall phase (see Figure 1). During the acquisition phase (80 trials) participants learned to associate an article of food with a specific consequence. In each trial one of eight stimuli (vegetables or fruits) was presented to the participant in one of two different contexts (indicated by the restaurant names “Zum Krug” (The Mug) and “Altes Stiftshaus” (The Dome) and a frame in either red or blue color). The stimulus in its context was first presented for 3 s, then a question asking whether the patient will develop a stomach-ache was superimposed, with the response options “Yes” or “No.” Response time was 4 s, participants responded by pressing the respective button on an fMRI-ready keyboard (Lumitouch, Photon Control Inc. Canada). After the response, or in case of a missing response after expiration of the response time, a feedback with the correct answer was displayed for 2 s, i.e., “The patient has a stomach ache” or “The patient does not have a stomach ache.” The actual response of the participant was not commented upon. The food stimuli were presented in randomized order, each stimulus was presented 10 times. Four stimuli were presented per context. Stimuli were counterbalanced with regard to their causing the aversive consequence of a stomach ache, with two stimuli per context causing stomach ache during acquisition, while the other two did not.


The DA antagonist tiapride impairs context-related extinction learning in a novel context without affecting renewal.

Lissek S, Glaubitz B, Wolf OT, Tegenthoff M - Front Behav Neurosci (2015)

Predictive learning task. (A) Example of a trial during acquisition of the task. Participants learned to predict whether certain kinds of food, eaten in a certain restaurant, would cause a stomach ache or not. After an intertrial interval of 5–9 s the stimulus was presented in its context for 3 s, then a question was superimposed on the screen “Do you expect your patient to get a stomach ache?” for maximum 4 s response time. Feedback was shown for 2 s, providing the correct answer, e.g., “The patient does not have a stomach ache.” (B) Design of the predictive learning task. In condition AAA, extinction occurs in the same context as acquisition. In condition ABA, extinction occurs in a context different from that during acquisition. In both conditions, the final test for the renewal effect is performed in the context of acquisition. (C) Food images used as stimuli.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4558976&req=5

Figure 1: Predictive learning task. (A) Example of a trial during acquisition of the task. Participants learned to predict whether certain kinds of food, eaten in a certain restaurant, would cause a stomach ache or not. After an intertrial interval of 5–9 s the stimulus was presented in its context for 3 s, then a question was superimposed on the screen “Do you expect your patient to get a stomach ache?” for maximum 4 s response time. Feedback was shown for 2 s, providing the correct answer, e.g., “The patient does not have a stomach ache.” (B) Design of the predictive learning task. In condition AAA, extinction occurs in the same context as acquisition. In condition ABA, extinction occurs in a context different from that during acquisition. In both conditions, the final test for the renewal effect is performed in the context of acquisition. (C) Food images used as stimuli.
Mentions: In the predictive learning task, participants were asked to put themselves in the position of a physician and predict whether various articles of food served in different restaurants would lead to the aversive consequence of a stomach ache in their patient. The learning process consisted of the three successive phases of (a) acquisition of associations, (b) extinction, and (c) recall phase (see Figure 1). During the acquisition phase (80 trials) participants learned to associate an article of food with a specific consequence. In each trial one of eight stimuli (vegetables or fruits) was presented to the participant in one of two different contexts (indicated by the restaurant names “Zum Krug” (The Mug) and “Altes Stiftshaus” (The Dome) and a frame in either red or blue color). The stimulus in its context was first presented for 3 s, then a question asking whether the patient will develop a stomach-ache was superimposed, with the response options “Yes” or “No.” Response time was 4 s, participants responded by pressing the respective button on an fMRI-ready keyboard (Lumitouch, Photon Control Inc. Canada). After the response, or in case of a missing response after expiration of the response time, a feedback with the correct answer was displayed for 2 s, i.e., “The patient has a stomach ache” or “The patient does not have a stomach ache.” The actual response of the participant was not commented upon. The food stimuli were presented in randomized order, each stimulus was presented 10 times. Four stimuli were presented per context. Stimuli were counterbalanced with regard to their causing the aversive consequence of a stomach ache, with two stimuli per context causing stomach ache during acquisition, while the other two did not.

Bottom Line: Groups did not differ in their level of ABA renewal.In ABA extinction, TIA showed reduced activation in dlPFC and OFC, hippocampus, and temporal regions.However, relating context to the appropriate association during recall does not appear to rely exclusively on DA signaling.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, BG University Hospital Bergmannsheil, Ruhr-University Bochum Bochum, Germany.

ABSTRACT
Renewal describes the recovery of an extinguished response if recall is tested in a context different from the extinction context. Behavioral studies demonstrated that attention to relevant context strengthens renewal. Neurotransmitters mediating attention and learning such as the dopaminergic (DA) system presumably modulate extinction learning and renewal. However, the role of DA for non-fear-based extinction learning and renewal in humans has not yet been investigated. This fMRI study investigated effects of DA-antagonism upon context-related extinction in a predictive learning task in which extinction occurred either in a novel (ABA) or an unchanged (AAA) context. The tiapride-treated group (TIA) showed significantly impaired ABA extinction learning and a significant within-group difference between ABA and AAA extinction, compared to placebo (PLAC). Groups did not differ in their level of ABA renewal. In ABA extinction, TIA showed reduced activation in dlPFC and OFC, hippocampus, and temporal regions. Across groups, activation in PFC and hippocampus correlated negatively with ABA extinction errors. Results suggest that in context-related extinction learning DA in PFC and hippocampus is involved in readjusting the cue-outcome relationship in the presence of a novel context. However, relating context to the appropriate association during recall does not appear to rely exclusively on DA signaling.

No MeSH data available.


Related in: MedlinePlus