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HER-2 and HER-3 expression in liver metastases of patients with colorectal cancer.

Styczen H, Nagelmeier I, Beissbarth T, Nietert M, Homayounfar K, Sprenger T, Boczek U, Stanek K, Kitz J, Wolff HA, Ghadimi BM, Middel P, Liersch T, Rüschoff J, Conradi LC - Oncotarget (2015)

Bottom Line: The results of immunohistochemistry (IHC) scoring and In-situ-hybridization (ISH)-amplification were correlated with clinical parameters and for the 179 resected patients with cancer-specific (CSS) and overall survival (OS).Positivity of HER-2 status (IHC score 2+/ISH+ and IHC 3+) was found in 8.2% of CRLM.Therefore, HER-2 and particularly HER-3 could serve as novel targets to be addressed within multimodal treatment approaches.

View Article: PubMed Central - PubMed

Affiliation: Department of General, Visceral and Pediatric Surgery, University Medical Center, Göttingen, Germany.

ABSTRACT

Objective: In this study, we evaluate the frequency of HER-2 and HER-3 expression in liver metastases from patients with colorectal cancer (CRLM). We analyzed the potential of HER-2 and HER-3 as therapeutic targets and evaluated their prognostic value.

Patients and methods: Overall 208 patients with CRLM were enrolled. HER-2 and HER-3 expression were determined in metastatic tissue of diagnostic punch biopsies (n = 29) or resection specimens (n = 179). The results of immunohistochemistry (IHC) scoring and In-situ-hybridization (ISH)-amplification were correlated with clinical parameters and for the 179 resected patients with cancer-specific (CSS) and overall survival (OS). The mean follow-up time was 56.7 months.

Results: Positivity of HER-2 status (IHC score 2+/ISH+ and IHC 3+) was found in 8.2% of CRLM. High expression of HER-3 (IHC score 2+ and IHC 3+) was detected in 75.0% of liver metastases. CSS after liver surgery was determined and was independent from the HER-2 status (p = 0.963); however HER-3 was prognostic with a favorable course for patients showing an overexpression of HER-3 (p = 0.037).

Conclusions: HER-2 overexpression occurs in only 8% of patients with CRLM but with 75% of cases HER-3 is frequently overexpressed in CRLM. Therefore, HER-2 and particularly HER-3 could serve as novel targets to be addressed within multimodal treatment approaches.

No MeSH data available.


Related in: MedlinePlus

Cancer-specific and overall survival survival after liver surgery in correlation with HER-2 expressionKaplan-Meier curve for CSS and OS of CRC patients with high and low HER-2 expression levels (p = 0.963, p = 0.747). The Cox model for CSS based on HER-2 status from 179 resection specimens of liver metastases.
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Figure 4: Cancer-specific and overall survival survival after liver surgery in correlation with HER-2 expressionKaplan-Meier curve for CSS and OS of CRC patients with high and low HER-2 expression levels (p = 0.963, p = 0.747). The Cox model for CSS based on HER-2 status from 179 resection specimens of liver metastases.

Mentions: HER-2 and HER-3 expression analyses were correlated with clinico-pathological parameters (such as gender, primary tumor localization, UICC status at diagnosis), OS and CSS and were tested for statistical significance. These results are presented in Table 1 and Table 2. We did not find any correlation between high expression of HER-2 or HER-3 and clinico-pathological parameters. With a mean follow up time of 56.7 months, patients with high HER-3 expression showed a better CSS (p = 0.037) and a better OS (p = 0.049) (Figure 3). The 5-year CSS of patients with high HER-3 expression was 43.5%, whereas patients with low HER-3 expression had a 5-year CSS of 23.9%. The 10-year survival (CSS) was 26.1% (high HER-3 expression) versus 15.9% (low HER-3 expression). Analyses of the prognostic significance of HER-2 expression revealed no difference in CSS (p = 0.963) or OS (p = 0.747) (Figure 4).


HER-2 and HER-3 expression in liver metastases of patients with colorectal cancer.

Styczen H, Nagelmeier I, Beissbarth T, Nietert M, Homayounfar K, Sprenger T, Boczek U, Stanek K, Kitz J, Wolff HA, Ghadimi BM, Middel P, Liersch T, Rüschoff J, Conradi LC - Oncotarget (2015)

Cancer-specific and overall survival survival after liver surgery in correlation with HER-2 expressionKaplan-Meier curve for CSS and OS of CRC patients with high and low HER-2 expression levels (p = 0.963, p = 0.747). The Cox model for CSS based on HER-2 status from 179 resection specimens of liver metastases.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4558136&req=5

Figure 4: Cancer-specific and overall survival survival after liver surgery in correlation with HER-2 expressionKaplan-Meier curve for CSS and OS of CRC patients with high and low HER-2 expression levels (p = 0.963, p = 0.747). The Cox model for CSS based on HER-2 status from 179 resection specimens of liver metastases.
Mentions: HER-2 and HER-3 expression analyses were correlated with clinico-pathological parameters (such as gender, primary tumor localization, UICC status at diagnosis), OS and CSS and were tested for statistical significance. These results are presented in Table 1 and Table 2. We did not find any correlation between high expression of HER-2 or HER-3 and clinico-pathological parameters. With a mean follow up time of 56.7 months, patients with high HER-3 expression showed a better CSS (p = 0.037) and a better OS (p = 0.049) (Figure 3). The 5-year CSS of patients with high HER-3 expression was 43.5%, whereas patients with low HER-3 expression had a 5-year CSS of 23.9%. The 10-year survival (CSS) was 26.1% (high HER-3 expression) versus 15.9% (low HER-3 expression). Analyses of the prognostic significance of HER-2 expression revealed no difference in CSS (p = 0.963) or OS (p = 0.747) (Figure 4).

Bottom Line: The results of immunohistochemistry (IHC) scoring and In-situ-hybridization (ISH)-amplification were correlated with clinical parameters and for the 179 resected patients with cancer-specific (CSS) and overall survival (OS).Positivity of HER-2 status (IHC score 2+/ISH+ and IHC 3+) was found in 8.2% of CRLM.Therefore, HER-2 and particularly HER-3 could serve as novel targets to be addressed within multimodal treatment approaches.

View Article: PubMed Central - PubMed

Affiliation: Department of General, Visceral and Pediatric Surgery, University Medical Center, Göttingen, Germany.

ABSTRACT

Objective: In this study, we evaluate the frequency of HER-2 and HER-3 expression in liver metastases from patients with colorectal cancer (CRLM). We analyzed the potential of HER-2 and HER-3 as therapeutic targets and evaluated their prognostic value.

Patients and methods: Overall 208 patients with CRLM were enrolled. HER-2 and HER-3 expression were determined in metastatic tissue of diagnostic punch biopsies (n = 29) or resection specimens (n = 179). The results of immunohistochemistry (IHC) scoring and In-situ-hybridization (ISH)-amplification were correlated with clinical parameters and for the 179 resected patients with cancer-specific (CSS) and overall survival (OS). The mean follow-up time was 56.7 months.

Results: Positivity of HER-2 status (IHC score 2+/ISH+ and IHC 3+) was found in 8.2% of CRLM. High expression of HER-3 (IHC score 2+ and IHC 3+) was detected in 75.0% of liver metastases. CSS after liver surgery was determined and was independent from the HER-2 status (p = 0.963); however HER-3 was prognostic with a favorable course for patients showing an overexpression of HER-3 (p = 0.037).

Conclusions: HER-2 overexpression occurs in only 8% of patients with CRLM but with 75% of cases HER-3 is frequently overexpressed in CRLM. Therefore, HER-2 and particularly HER-3 could serve as novel targets to be addressed within multimodal treatment approaches.

No MeSH data available.


Related in: MedlinePlus