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A second component of the SltA-dependent cation tolerance pathway in Aspergillus nidulans.

Mellado L, Calcagno-Pizarelli AM, Lockington RA, Cortese MS, Kelly JM, Arst HN, Espeso EA - Fungal Genet. Biol. (2015)

Bottom Line: This functional relationship is reinforced by the fact that numerous mutations in both slt loci can be isolated as suppressors of poor colonial growth resulting from certain vps (vacuolar protein sorting) mutations.Finally, it is noteworthy that SltA and SltB have a similar, limited phylogenetic distribution, being restricted to the pezizomycotina subphylum.The relevance of the Slt regulatory pathway to cell structure, intracellular trafficking and cation homeostasis and its restricted phylogenetic distribution makes this pathway of general interest for future investigation and as a source of targets for antifungal drugs.

View Article: PubMed Central - PubMed

Affiliation: Departamento de Biología Celular y Molecular, Centro de Investigaciones Biológicas, CSIC, Ramiro de Maeztu, 9, 28040 Madrid, Spain.

No MeSH data available.


Related in: MedlinePlus

Alignment of the SltB and PskA, AN7985, proteins. The amino acid sequence conservation between SltB and PskA is confined to the pseudokinase domain. Alignment of the SltB fragment between residues 361 and 576, and residues 301-523 of PskA is shown, generated by Blast2p (http://blast.ncbi.nlm.nih.gov/). Identical residues are indicated and + denotes conserved residues using Blosum62 comparison matrix.
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f0060: Alignment of the SltB and PskA, AN7985, proteins. The amino acid sequence conservation between SltB and PskA is confined to the pseudokinase domain. Alignment of the SltB fragment between residues 361 and 576, and residues 301-523 of PskA is shown, generated by Blast2p (http://blast.ncbi.nlm.nih.gov/). Identical residues are indicated and + denotes conserved residues using Blosum62 comparison matrix.


A second component of the SltA-dependent cation tolerance pathway in Aspergillus nidulans.

Mellado L, Calcagno-Pizarelli AM, Lockington RA, Cortese MS, Kelly JM, Arst HN, Espeso EA - Fungal Genet. Biol. (2015)

Alignment of the SltB and PskA, AN7985, proteins. The amino acid sequence conservation between SltB and PskA is confined to the pseudokinase domain. Alignment of the SltB fragment between residues 361 and 576, and residues 301-523 of PskA is shown, generated by Blast2p (http://blast.ncbi.nlm.nih.gov/). Identical residues are indicated and + denotes conserved residues using Blosum62 comparison matrix.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4557415&req=5

f0060: Alignment of the SltB and PskA, AN7985, proteins. The amino acid sequence conservation between SltB and PskA is confined to the pseudokinase domain. Alignment of the SltB fragment between residues 361 and 576, and residues 301-523 of PskA is shown, generated by Blast2p (http://blast.ncbi.nlm.nih.gov/). Identical residues are indicated and + denotes conserved residues using Blosum62 comparison matrix.
Bottom Line: This functional relationship is reinforced by the fact that numerous mutations in both slt loci can be isolated as suppressors of poor colonial growth resulting from certain vps (vacuolar protein sorting) mutations.Finally, it is noteworthy that SltA and SltB have a similar, limited phylogenetic distribution, being restricted to the pezizomycotina subphylum.The relevance of the Slt regulatory pathway to cell structure, intracellular trafficking and cation homeostasis and its restricted phylogenetic distribution makes this pathway of general interest for future investigation and as a source of targets for antifungal drugs.

View Article: PubMed Central - PubMed

Affiliation: Departamento de Biología Celular y Molecular, Centro de Investigaciones Biológicas, CSIC, Ramiro de Maeztu, 9, 28040 Madrid, Spain.

No MeSH data available.


Related in: MedlinePlus