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The Efficacy of One Molar Contrast Material in the Evaluation of Breast Lesions with MR Imaging.

Toprak N, Unal O, Avcu S - Pol J Radiol (2015)

Bottom Line: Thirty-seven women (age range: 22-77 years, mean: 43.7 years) with 76 breast lesions were included in this study.Dynamic post-contrast images with 0.2 mL/kg gadobutrol (Gadovist) injection were obtained in all patients.By increasing CNR and providing increased perilesional vascularity, Gadovist can help in the determination of malignant breast lesions.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Yüzüncü Yıl University Medical Faculty, Van, Turkey.

ABSTRACT

Background: To investigate the efficacy of 1 molar (containing 1 mol/mL gadobutrol) contrast material in the differentiation of malignant and benign breast lesions with MRI.

Material/methods: Thirty-seven women (age range: 22-77 years, mean: 43.7 years) with 76 breast lesions were included in this study. Dynamic post-contrast images with 0.2 mL/kg gadobutrol (Gadovist) injection were obtained in all patients. Contrast-to-noise-ratio (CNR) of the lesions, as well as their contrast enhancement patterns (ring, heterogeneous, homogenous), and perilesional increased vascularity were studied.

Results: Fifty-six benign and 20 malignant lesions were examined histopathologically. In malignant cases, heterogeneous and peripheral enhancements were most commonly determined, whereas homogeneous enhancement was most commonly determined in benign cases. CNR was 450% in malignant lesions, and 60% in benign lesions.

Conclusions: Type II/III contrast-time curves, ring/heterogeneous enhancement, prominent increase in CNR, and perilesional vascularity increase are important findings determining malignancy, whereas Type I curves, homogenous enhancement, a slight increase in CNR, and absence of perilesional vascularity increase support findings of benign breast lesions. By increasing CNR and providing increased perilesional vascularity, Gadovist can help in the determination of malignant breast lesions.

No MeSH data available.


Related in: MedlinePlus

Post-Gadovist T1-weighted image (A) of a 37-year-old woman shows heterogeneous enhanced mass lesion in the left breast. The lesion displays Type I contrast-time curve (B). The histopathology of the lesion revealed hamartoma.
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f4-poljradiol-80-401: Post-Gadovist T1-weighted image (A) of a 37-year-old woman shows heterogeneous enhanced mass lesion in the left breast. The lesion displays Type I contrast-time curve (B). The histopathology of the lesion revealed hamartoma.

Mentions: Fifty-six out of 76 lesions were considered benign. Twenty-two lesions that were considered benign also had a histopathological diagnosis. In histopathological analysis, 3 lesions were evaluated as granulomatous mastitis (Figure 3), 11 lesions as fibroadenoma (FA), 3 lesions as adenosis (benign glandular changes), 2 lesions as papilloma, 1 lesion as intramammarian lymph node (IMLN), 1 lesion as fibroadenolipoma (FAL) (Figure 4), and 1 lesion as post-operative scar tissue and radiation necrosis (Figure 5).


The Efficacy of One Molar Contrast Material in the Evaluation of Breast Lesions with MR Imaging.

Toprak N, Unal O, Avcu S - Pol J Radiol (2015)

Post-Gadovist T1-weighted image (A) of a 37-year-old woman shows heterogeneous enhanced mass lesion in the left breast. The lesion displays Type I contrast-time curve (B). The histopathology of the lesion revealed hamartoma.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4557414&req=5

f4-poljradiol-80-401: Post-Gadovist T1-weighted image (A) of a 37-year-old woman shows heterogeneous enhanced mass lesion in the left breast. The lesion displays Type I contrast-time curve (B). The histopathology of the lesion revealed hamartoma.
Mentions: Fifty-six out of 76 lesions were considered benign. Twenty-two lesions that were considered benign also had a histopathological diagnosis. In histopathological analysis, 3 lesions were evaluated as granulomatous mastitis (Figure 3), 11 lesions as fibroadenoma (FA), 3 lesions as adenosis (benign glandular changes), 2 lesions as papilloma, 1 lesion as intramammarian lymph node (IMLN), 1 lesion as fibroadenolipoma (FAL) (Figure 4), and 1 lesion as post-operative scar tissue and radiation necrosis (Figure 5).

Bottom Line: Thirty-seven women (age range: 22-77 years, mean: 43.7 years) with 76 breast lesions were included in this study.Dynamic post-contrast images with 0.2 mL/kg gadobutrol (Gadovist) injection were obtained in all patients.By increasing CNR and providing increased perilesional vascularity, Gadovist can help in the determination of malignant breast lesions.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Yüzüncü Yıl University Medical Faculty, Van, Turkey.

ABSTRACT

Background: To investigate the efficacy of 1 molar (containing 1 mol/mL gadobutrol) contrast material in the differentiation of malignant and benign breast lesions with MRI.

Material/methods: Thirty-seven women (age range: 22-77 years, mean: 43.7 years) with 76 breast lesions were included in this study. Dynamic post-contrast images with 0.2 mL/kg gadobutrol (Gadovist) injection were obtained in all patients. Contrast-to-noise-ratio (CNR) of the lesions, as well as their contrast enhancement patterns (ring, heterogeneous, homogenous), and perilesional increased vascularity were studied.

Results: Fifty-six benign and 20 malignant lesions were examined histopathologically. In malignant cases, heterogeneous and peripheral enhancements were most commonly determined, whereas homogeneous enhancement was most commonly determined in benign cases. CNR was 450% in malignant lesions, and 60% in benign lesions.

Conclusions: Type II/III contrast-time curves, ring/heterogeneous enhancement, prominent increase in CNR, and perilesional vascularity increase are important findings determining malignancy, whereas Type I curves, homogenous enhancement, a slight increase in CNR, and absence of perilesional vascularity increase support findings of benign breast lesions. By increasing CNR and providing increased perilesional vascularity, Gadovist can help in the determination of malignant breast lesions.

No MeSH data available.


Related in: MedlinePlus