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Immunological & metabolic responses to a therapeutic course of Basti in obesity.

Thatte U, Chiplunkar S, Bhalerao S, Kulkarni A, Ghungralkar R, Panchal F, Vetale S, Teli P, Kumbhar D, Munshi R - Indian J. Med. Res. (2015)

Bottom Line: A significant reduction ( P<0.001) in weight, BMI, upper arm and abdominal circumference was seen at S3, along with a decrease in serum interferon (IFN)-γ (P<0.02), interleukin (IL)-6 ( P<0.02) and ferritin (P<0.05) and increase in IgM levels ( P<0.02).Peripheral blood lymphocytes (PBLs) stimulated with anti-CD3 monoclonal antibodies showed significant increase in reactive oxygen species (ROS) generation and calcium flux after Basti.The study also documents the safety of Basti procedure.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Pharmacology, Seth GS Medical College & KEM Hospital, Mumbai, India.

ABSTRACT

Background & objectives: Basti (medicated enema) is a popular Ayurvedic intervention recommended for obesity. However, there are no data to show whether any physiological or biochemical changes occur following this treatment. This study was conducted to identify the immunological and metabolic changes in obese individuals after a therapeutic course of Basti.

Methods: Thirty two obese individuals (18 and 60 yr) with a body mass index (BMI) ≥30 kg/m [2] who received a therapeutic course of 16 enemas (Basti) followed by a specific diet and lifestyle regimen for a period of 32 days as their treatment for obesity, were enrolled in the study. Clinical examination, measurement of immune and metabolic markers were done before (S1), immediately after (S2) and 90 days after the completion of therapy (S3).

Results: A significant reduction ( P<0.001) in weight, BMI, upper arm and abdominal circumference was seen at S3, along with a decrease in serum interferon (IFN)-γ (P<0.02), interleukin (IL)-6 ( P<0.02) and ferritin (P<0.05) and increase in IgM levels ( P<0.02). Peripheral blood lymphocytes (PBLs) stimulated with anti-CD3 monoclonal antibodies showed significant increase in reactive oxygen species (ROS) generation and calcium flux after Basti. All organ function tests revealed no changes.

Interpretation & conclusions: Our study documents that a therapeutic course of Basti modulates immune responses by regulating pro-inflammatory cytokines, immunoglobulins and functional properties of T-cells. These changes are associated with a reduction in the body weight which is maintained even after three months of treatment. The study also documents the safety of Basti procedure.

No MeSH data available.


Related in: MedlinePlus

Effect of IgM and IgG immunoglobulin levels in serum of obese individuals. Figures represent mean values of IgM and IgG in mg/ml ± SD (n=32) (*P<0.02).
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Figure 5: Effect of IgM and IgG immunoglobulin levels in serum of obese individuals. Figures represent mean values of IgM and IgG in mg/ml ± SD (n=32) (*P<0.02).

Mentions: As seen in Fig. 3, the levels of IgM were markedly elevated from 1.06 ± 0.68 mg/ml at S1 to 3.76 ± 4.08 mg/ml at S2 (P<0.02) with a significant reduction at S3 (1.67±1.10 mg/ml; P<0.02) as compared with S1. A marginal decrease in levels of IgG was at S2 with significant drop (P<0.02) at S3. A positive correlation between IgG and IL-6 levels was observed at S2 (r=0.39) and S3 (0.66).


Immunological & metabolic responses to a therapeutic course of Basti in obesity.

Thatte U, Chiplunkar S, Bhalerao S, Kulkarni A, Ghungralkar R, Panchal F, Vetale S, Teli P, Kumbhar D, Munshi R - Indian J. Med. Res. (2015)

Effect of IgM and IgG immunoglobulin levels in serum of obese individuals. Figures represent mean values of IgM and IgG in mg/ml ± SD (n=32) (*P<0.02).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4557251&req=5

Figure 5: Effect of IgM and IgG immunoglobulin levels in serum of obese individuals. Figures represent mean values of IgM and IgG in mg/ml ± SD (n=32) (*P<0.02).
Mentions: As seen in Fig. 3, the levels of IgM were markedly elevated from 1.06 ± 0.68 mg/ml at S1 to 3.76 ± 4.08 mg/ml at S2 (P<0.02) with a significant reduction at S3 (1.67±1.10 mg/ml; P<0.02) as compared with S1. A marginal decrease in levels of IgG was at S2 with significant drop (P<0.02) at S3. A positive correlation between IgG and IL-6 levels was observed at S2 (r=0.39) and S3 (0.66).

Bottom Line: A significant reduction ( P<0.001) in weight, BMI, upper arm and abdominal circumference was seen at S3, along with a decrease in serum interferon (IFN)-γ (P<0.02), interleukin (IL)-6 ( P<0.02) and ferritin (P<0.05) and increase in IgM levels ( P<0.02).Peripheral blood lymphocytes (PBLs) stimulated with anti-CD3 monoclonal antibodies showed significant increase in reactive oxygen species (ROS) generation and calcium flux after Basti.The study also documents the safety of Basti procedure.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Pharmacology, Seth GS Medical College & KEM Hospital, Mumbai, India.

ABSTRACT

Background & objectives: Basti (medicated enema) is a popular Ayurvedic intervention recommended for obesity. However, there are no data to show whether any physiological or biochemical changes occur following this treatment. This study was conducted to identify the immunological and metabolic changes in obese individuals after a therapeutic course of Basti.

Methods: Thirty two obese individuals (18 and 60 yr) with a body mass index (BMI) ≥30 kg/m [2] who received a therapeutic course of 16 enemas (Basti) followed by a specific diet and lifestyle regimen for a period of 32 days as their treatment for obesity, were enrolled in the study. Clinical examination, measurement of immune and metabolic markers were done before (S1), immediately after (S2) and 90 days after the completion of therapy (S3).

Results: A significant reduction ( P<0.001) in weight, BMI, upper arm and abdominal circumference was seen at S3, along with a decrease in serum interferon (IFN)-γ (P<0.02), interleukin (IL)-6 ( P<0.02) and ferritin (P<0.05) and increase in IgM levels ( P<0.02). Peripheral blood lymphocytes (PBLs) stimulated with anti-CD3 monoclonal antibodies showed significant increase in reactive oxygen species (ROS) generation and calcium flux after Basti. All organ function tests revealed no changes.

Interpretation & conclusions: Our study documents that a therapeutic course of Basti modulates immune responses by regulating pro-inflammatory cytokines, immunoglobulins and functional properties of T-cells. These changes are associated with a reduction in the body weight which is maintained even after three months of treatment. The study also documents the safety of Basti procedure.

No MeSH data available.


Related in: MedlinePlus