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A retrospective study of head and neck re-irradiation for patients with recurrent or second primary head and neck cancer: the McGill University experience.

Al-Wassia R, Vakilian S, Holly C, Sultanem K, Shenouda G - J Otolaryngol Head Neck Surg (2015)

Bottom Line: The results are expressed as actuarial values using the Kaplan-Meier estimates.There were two treatment-related deaths (grade 5 toxicity).Continuous course re-irradiation in patients with LRR or SP head and neck cancer is feasible with acceptable toxicity.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, King Abdulaziz University, Abdullah Suleiman Street, P.O Box 80200, 21589, Jeddah, Saudi Arabia. ralwassia@kau.edu.sa.

ABSTRACT

Background: We report our experience with patients who received re-irradiation to the head and neck area for locoregional recurrences (LRR) or second primaries (SP) in a previously irradiated field.

Methods: We reviewed 27 consecutive patients with a diagnosis of LRR or SP head and neck carcinoma treated with a second course of radiotherapy between April 2004 and July 2012. The main outcome measures were local control, overall survival, and complications. The results are expressed as actuarial values using the Kaplan-Meier estimates.

Results: The median follow-up time was 24.7 months (range: 11 days-79.3 months). There were 23 males and four females with a median age of 61 years (range: 40-87 years). The actuarial overall survival rates at 1, 2, and 5 years were 77, 59, and 57%, respectively. The actuarial local control rate was 80, 52, and 52% at 1, 2, and 5 years, respectively. Three patients developed systemic metastases. The rate of grade 3 toxicity was 26%, and that of grade 4 toxicity was 3%. There were two treatment-related deaths (grade 5 toxicity).

Conclusions: Continuous course re-irradiation in patients with LRR or SP head and neck cancer is feasible with acceptable toxicity. With current encouraging rates of local control and overall survival, this option should be discussed with patients who have few alternative therapeutic options.

No MeSH data available.


Related in: MedlinePlus

Local control and overall survival
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Fig2: Local control and overall survival

Mentions: The actuarial estimates of local control were 80, 52, and 52 % at 1, 2, and 5 years, as shown in Fig. 2. The median time to the first recurrence or the SP was 24.5 months (range: 4.6–283 months). The median time to the third diagnosis or second failure was 17 months (range: 3.5–192 months).Fig. 2


A retrospective study of head and neck re-irradiation for patients with recurrent or second primary head and neck cancer: the McGill University experience.

Al-Wassia R, Vakilian S, Holly C, Sultanem K, Shenouda G - J Otolaryngol Head Neck Surg (2015)

Local control and overall survival
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4557220&req=5

Fig2: Local control and overall survival
Mentions: The actuarial estimates of local control were 80, 52, and 52 % at 1, 2, and 5 years, as shown in Fig. 2. The median time to the first recurrence or the SP was 24.5 months (range: 4.6–283 months). The median time to the third diagnosis or second failure was 17 months (range: 3.5–192 months).Fig. 2

Bottom Line: The results are expressed as actuarial values using the Kaplan-Meier estimates.There were two treatment-related deaths (grade 5 toxicity).Continuous course re-irradiation in patients with LRR or SP head and neck cancer is feasible with acceptable toxicity.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, King Abdulaziz University, Abdullah Suleiman Street, P.O Box 80200, 21589, Jeddah, Saudi Arabia. ralwassia@kau.edu.sa.

ABSTRACT

Background: We report our experience with patients who received re-irradiation to the head and neck area for locoregional recurrences (LRR) or second primaries (SP) in a previously irradiated field.

Methods: We reviewed 27 consecutive patients with a diagnosis of LRR or SP head and neck carcinoma treated with a second course of radiotherapy between April 2004 and July 2012. The main outcome measures were local control, overall survival, and complications. The results are expressed as actuarial values using the Kaplan-Meier estimates.

Results: The median follow-up time was 24.7 months (range: 11 days-79.3 months). There were 23 males and four females with a median age of 61 years (range: 40-87 years). The actuarial overall survival rates at 1, 2, and 5 years were 77, 59, and 57%, respectively. The actuarial local control rate was 80, 52, and 52% at 1, 2, and 5 years, respectively. Three patients developed systemic metastases. The rate of grade 3 toxicity was 26%, and that of grade 4 toxicity was 3%. There were two treatment-related deaths (grade 5 toxicity).

Conclusions: Continuous course re-irradiation in patients with LRR or SP head and neck cancer is feasible with acceptable toxicity. With current encouraging rates of local control and overall survival, this option should be discussed with patients who have few alternative therapeutic options.

No MeSH data available.


Related in: MedlinePlus