Limits...
The Role of Procalcitonin Levels in Assessing the Severity of Clostridium Difficile Infection.

Dazley J, Shaaban H, Afridi S, Slim J - J Glob Infect Dis (2015 Jul-Sep)

View Article: PubMed Central - PubMed

Affiliation: Department of Infectious Diseases, St Michael's Medical Center, Newark, New Jersey, United States.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Sir, Clostridium difficile-associated disease (CDAD) is the most recognized cause of healthcare-associated infectious diarrhea and a major cause of morbidity and mortality in hospitalized patients... This analysis was conducted in order to evaluate the role of PCT levels as a diagnostic adjunct in the identification of severe CDAD... CDAD was defined as having diarrhea (i. e., more than watery stools/24 h) plus a positive Clostridium difficile stool assay (positive enzyme immunoassay for toxin A/B test or polymerase chain reaction (PCR) test)... Only patients who had a PCT level drawn within 24 h of confirmation of CDAD were included... Receiver operating characteristic (ROC) curve analysis was done to determine the best cutoff point for PCT. [Figure 1] Fifty-three patients were included in the study, and their characteristics included the following: [Table 1] Mean age in years, 69.2 ± 19 (43.4%); male gender 41.5%; and patients with severe CDAD, 62.3%... Age, gender, concurrent bacterial infection, and residence in the nursing home did not affect PCT's association with severe CDAD... PCT > 0.5 is a marker to identify severe CDAD; specificity 86.1%, sensitivity 88.2%, positive predictive value (PPV) 93.9%, and negative predictive value (NPV) 75.0%. [Figure 1] [Table 2]... PCT levels at > 0.5 μg/mL appear to be a good indicator of severe CDAD, with a very high PPV. [Table 3] Prospective, larger studies are needed to validate this finding... Further research is needed as to whether following PCT levels may be helpful in determining resolution of the disease, risk of relapse, or predict mortality.

No MeSH data available.


Related in: MedlinePlus

Logistic regression analysis was done to determine the association between severe CDAD and PCT and receiver operating characteristic (ROC) curve analysis was done to determine the best cut-off point for PCT
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4557143&req=5

Figure 1: Logistic regression analysis was done to determine the association between severe CDAD and PCT and receiver operating characteristic (ROC) curve analysis was done to determine the best cut-off point for PCT

Mentions: Logistic regression analysis was done to determine the association between severe CDAD and PCT, as well as the risk factors. Receiver operating characteristic (ROC) curve analysis was done to determine the best cutoff point for PCT. [Figure 1] Fifty-three patients were included in the study, and their characteristics included the following: [Table 1] Mean age in years, 69.2 ± 19 (43.4%); male gender 41.5%; and patients with severe CDAD, 62.3%. Age, gender, concurrent bacterial infection, and residence in the nursing home did not affect PCT's association with severe CDAD.


The Role of Procalcitonin Levels in Assessing the Severity of Clostridium Difficile Infection.

Dazley J, Shaaban H, Afridi S, Slim J - J Glob Infect Dis (2015 Jul-Sep)

Logistic regression analysis was done to determine the association between severe CDAD and PCT and receiver operating characteristic (ROC) curve analysis was done to determine the best cut-off point for PCT
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4557143&req=5

Figure 1: Logistic regression analysis was done to determine the association between severe CDAD and PCT and receiver operating characteristic (ROC) curve analysis was done to determine the best cut-off point for PCT
Mentions: Logistic regression analysis was done to determine the association between severe CDAD and PCT, as well as the risk factors. Receiver operating characteristic (ROC) curve analysis was done to determine the best cutoff point for PCT. [Figure 1] Fifty-three patients were included in the study, and their characteristics included the following: [Table 1] Mean age in years, 69.2 ± 19 (43.4%); male gender 41.5%; and patients with severe CDAD, 62.3%. Age, gender, concurrent bacterial infection, and residence in the nursing home did not affect PCT's association with severe CDAD.

View Article: PubMed Central - PubMed

Affiliation: Department of Infectious Diseases, St Michael's Medical Center, Newark, New Jersey, United States.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Sir, Clostridium difficile-associated disease (CDAD) is the most recognized cause of healthcare-associated infectious diarrhea and a major cause of morbidity and mortality in hospitalized patients... This analysis was conducted in order to evaluate the role of PCT levels as a diagnostic adjunct in the identification of severe CDAD... CDAD was defined as having diarrhea (i. e., more than watery stools/24 h) plus a positive Clostridium difficile stool assay (positive enzyme immunoassay for toxin A/B test or polymerase chain reaction (PCR) test)... Only patients who had a PCT level drawn within 24 h of confirmation of CDAD were included... Receiver operating characteristic (ROC) curve analysis was done to determine the best cutoff point for PCT. [Figure 1] Fifty-three patients were included in the study, and their characteristics included the following: [Table 1] Mean age in years, 69.2 ± 19 (43.4%); male gender 41.5%; and patients with severe CDAD, 62.3%... Age, gender, concurrent bacterial infection, and residence in the nursing home did not affect PCT's association with severe CDAD... PCT > 0.5 is a marker to identify severe CDAD; specificity 86.1%, sensitivity 88.2%, positive predictive value (PPV) 93.9%, and negative predictive value (NPV) 75.0%. [Figure 1] [Table 2]... PCT levels at > 0.5 μg/mL appear to be a good indicator of severe CDAD, with a very high PPV. [Table 3] Prospective, larger studies are needed to validate this finding... Further research is needed as to whether following PCT levels may be helpful in determining resolution of the disease, risk of relapse, or predict mortality.

No MeSH data available.


Related in: MedlinePlus