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A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi.

Wang YT, Xue YR, Liu CH - Mar Drugs (2015)

Bottom Line: To date more than 180 bioactive secondary metabolites derived from deep-sea fungi have been documented in the literature.These include compounds with anticancer, antimicrobial, antifungal, antiprotozoal, and antiviral activities.In this review, we summarize the structures and bioactivities of these metabolites to provide help for novel drug development.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University. wangyanting2012@qq.com.

ABSTRACT
Deep-sea fungi, the fungi that inhabit the sea and the sediment at depths of over 1000 m below the surface, have become an important source of industrial, agricultural, and nutraceutical compounds based on their diversities in both structure and function. Since the first study of deep-sea fungi in the Atlantic Ocean at a depth of 4450 m was conducted approximately 50 years ago, hundreds of isolates of deep-sea fungi have been reported based on culture-dependent methods. To date more than 180 bioactive secondary metabolites derived from deep-sea fungi have been documented in the literature. These include compounds with anticancer, antimicrobial, antifungal, antiprotozoal, and antiviral activities. In this review, we summarize the structures and bioactivities of these metabolites to provide help for novel drug development.

No MeSH data available.


Chemical structure of compound 171.
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marinedrugs-13-04594-f028: Chemical structure of compound 171.

Mentions: Although many polyketide compounds have been identified, the compounds derived from deep-sea fungi with antiviral activity are rare. Only one fungal hybrid polyketide with a new structure, cladosin C (171) (Figure 28), has been reported from the deep-sea fungus Cladosporium sphaerospermum 2005-01-E3. However, this compound shows good antiviral activity against influenza A H1N1 virus with an IC50 of 276 μM [9].


A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi.

Wang YT, Xue YR, Liu CH - Mar Drugs (2015)

Chemical structure of compound 171.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4556995&req=5

marinedrugs-13-04594-f028: Chemical structure of compound 171.
Mentions: Although many polyketide compounds have been identified, the compounds derived from deep-sea fungi with antiviral activity are rare. Only one fungal hybrid polyketide with a new structure, cladosin C (171) (Figure 28), has been reported from the deep-sea fungus Cladosporium sphaerospermum 2005-01-E3. However, this compound shows good antiviral activity against influenza A H1N1 virus with an IC50 of 276 μM [9].

Bottom Line: To date more than 180 bioactive secondary metabolites derived from deep-sea fungi have been documented in the literature.These include compounds with anticancer, antimicrobial, antifungal, antiprotozoal, and antiviral activities.In this review, we summarize the structures and bioactivities of these metabolites to provide help for novel drug development.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University. wangyanting2012@qq.com.

ABSTRACT
Deep-sea fungi, the fungi that inhabit the sea and the sediment at depths of over 1000 m below the surface, have become an important source of industrial, agricultural, and nutraceutical compounds based on their diversities in both structure and function. Since the first study of deep-sea fungi in the Atlantic Ocean at a depth of 4450 m was conducted approximately 50 years ago, hundreds of isolates of deep-sea fungi have been reported based on culture-dependent methods. To date more than 180 bioactive secondary metabolites derived from deep-sea fungi have been documented in the literature. These include compounds with anticancer, antimicrobial, antifungal, antiprotozoal, and antiviral activities. In this review, we summarize the structures and bioactivities of these metabolites to provide help for novel drug development.

No MeSH data available.