Limits...
A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi.

Wang YT, Xue YR, Liu CH - Mar Drugs (2015)

Bottom Line: To date more than 180 bioactive secondary metabolites derived from deep-sea fungi have been documented in the literature.These include compounds with anticancer, antimicrobial, antifungal, antiprotozoal, and antiviral activities.In this review, we summarize the structures and bioactivities of these metabolites to provide help for novel drug development.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University. wangyanting2012@qq.com.

ABSTRACT
Deep-sea fungi, the fungi that inhabit the sea and the sediment at depths of over 1000 m below the surface, have become an important source of industrial, agricultural, and nutraceutical compounds based on their diversities in both structure and function. Since the first study of deep-sea fungi in the Atlantic Ocean at a depth of 4450 m was conducted approximately 50 years ago, hundreds of isolates of deep-sea fungi have been reported based on culture-dependent methods. To date more than 180 bioactive secondary metabolites derived from deep-sea fungi have been documented in the literature. These include compounds with anticancer, antimicrobial, antifungal, antiprotozoal, and antiviral activities. In this review, we summarize the structures and bioactivities of these metabolites to provide help for novel drug development.

No MeSH data available.


Chemical structures of compounds 73–75.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4556995&req=5

marinedrugs-13-04594-f010: Chemical structures of compounds 73–75.

Mentions: Shang et al. (2012) reported three alkaloids (73–75) (Figure 10) that were isolated from the deep-sea fungus Penicillium commune SD-118. These alkaloid compounds show potent cytotoxicity against the DU145 cell line with IC50 of 4.3–5.0 μM. Moreover, compound 75 shows moderate cytotoxicity toward the HepG2, NCIH460, HeLa, and MDA-MB-231 cell lines with IC50 of 0.03, 0.05, 0.05, and 0.03 mM, respectively [50].


A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi.

Wang YT, Xue YR, Liu CH - Mar Drugs (2015)

Chemical structures of compounds 73–75.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4556995&req=5

marinedrugs-13-04594-f010: Chemical structures of compounds 73–75.
Mentions: Shang et al. (2012) reported three alkaloids (73–75) (Figure 10) that were isolated from the deep-sea fungus Penicillium commune SD-118. These alkaloid compounds show potent cytotoxicity against the DU145 cell line with IC50 of 4.3–5.0 μM. Moreover, compound 75 shows moderate cytotoxicity toward the HepG2, NCIH460, HeLa, and MDA-MB-231 cell lines with IC50 of 0.03, 0.05, 0.05, and 0.03 mM, respectively [50].

Bottom Line: To date more than 180 bioactive secondary metabolites derived from deep-sea fungi have been documented in the literature.These include compounds with anticancer, antimicrobial, antifungal, antiprotozoal, and antiviral activities.In this review, we summarize the structures and bioactivities of these metabolites to provide help for novel drug development.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University. wangyanting2012@qq.com.

ABSTRACT
Deep-sea fungi, the fungi that inhabit the sea and the sediment at depths of over 1000 m below the surface, have become an important source of industrial, agricultural, and nutraceutical compounds based on their diversities in both structure and function. Since the first study of deep-sea fungi in the Atlantic Ocean at a depth of 4450 m was conducted approximately 50 years ago, hundreds of isolates of deep-sea fungi have been reported based on culture-dependent methods. To date more than 180 bioactive secondary metabolites derived from deep-sea fungi have been documented in the literature. These include compounds with anticancer, antimicrobial, antifungal, antiprotozoal, and antiviral activities. In this review, we summarize the structures and bioactivities of these metabolites to provide help for novel drug development.

No MeSH data available.