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Using Copper to Improve the Well-Being of the Skin.

Borkow G - Curr Chem Biol (2014)

Bottom Line: On the other hand, copper is involved in numerous physiological and metabolic processes critical for the appropriate functioning of almost all tissues in the human body.These include studies showing a) cure of athlete's foot infections and improvement in skin elasticity, especially important for individuals suffering from diabetes; b) reduction of facial fine line and wrinkles; and c) enhancement of wound healing; by copper oxide embedded socks, pillowcases and wound dressings, respectively.The manuscript also reviews and discusses the mechanisms by which the presence of copper in these products improves skin well-being.

View Article: PubMed Central - PubMed

Affiliation: Cupron Inc. Hasadnaot 10, Herzelia, Israel.

ABSTRACT

Copper has two key properties that are being exploited in consumer and medical device products in the last decade. On the one hand, copper has potent biocidal properties. On the other hand, copper is involved in numerous physiological and metabolic processes critical for the appropriate functioning of almost all tissues in the human body. In the skin, copper is involved in the synthesis and stabilization of extracellular matrix skin proteins and angiogenesis. This manuscript reviews clinical studies that show that the use of textile consumer and medical device products, embedded with microscopic copper oxide particles, improve the well-being of the skin. These include studies showing a) cure of athlete's foot infections and improvement in skin elasticity, especially important for individuals suffering from diabetes; b) reduction of facial fine line and wrinkles; and c) enhancement of wound healing; by copper oxide embedded socks, pillowcases and wound dressings, respectively. The manuscript also reviews and discusses the mechanisms by which the presence of copper in these products improves skin well-being.

No MeSH data available.


Related in: MedlinePlus

Increased expression of angiogenic factors and other proteins involved in wound healing. Significantand differential upregulation of mRNA expression of key proteins involved in the wound healing process in thegroup of mice treated with the copper oxide wound dressings as compared to mice treated with control wounddressing without copper. Itgav - Integrin alpha V; and Itgb3 - Integrin beta 3. Data taken from reference [38].
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Figure 9: Increased expression of angiogenic factors and other proteins involved in wound healing. Significantand differential upregulation of mRNA expression of key proteins involved in the wound healing process in thegroup of mice treated with the copper oxide wound dressings as compared to mice treated with control wounddressing without copper. Itgav - Integrin alpha V; and Itgb3 - Integrin beta 3. Data taken from reference [38].

Mentions: We tested how the continuous application of copper oxide impregnated wound dressing could help heal full thickness skin wounds inflicted in genetically engineered diabetic mice. We found that the wounds healed statistically significantly faster (p<0.01) than wounds treated with control wound dressing without copper or with wound dressing containing silver [38]. Histological analysis revealed normal epidermal and dermal regeneration, granulation tissue formation, formation of numerous new blood vessels, generation of new hair follicles and sebaceous glands, chronic inflammatory infiltrate, and fibroplasia, with no precancerous changes or atypia of any kind (Fig. 8A). mRNA expression analysis of biopsies taken from the wound beds at several days following wounding, revealed significant upregulation of key proteins involved in wound healing in the mice treated with the copper oxide wound dressings as compared to the control mice (Fig. 9). For example, one day after wounding there was ~6 fold increase in integrins (proteins that bind extracellular matrix proteins and transduce signals crucial for cell processes in wound healing [95]) and 22 fold increase in placental growth factor (pLGF; an angiogenic factor known to be markedly reduced in diabetic wounds). Five days after wounding there was a 33, 141 and 112 fold increase in TGF-β1, TGF-β2 and TGF-β3, proteins that stimulate collagen and elastin fiber formation and deposition [4, 6] and are involved in scar formation [7]. Hypoxia-inducible factor-1alpha (Hif-1α) was significantly upregulated by 5 and 88-fold at 5 and 10 days following wounding, respectively. Hif-1α, a regulatory protein involved in oxidative stress [96], activates many genes involved in wound angiogenesis and wound healing [97]. Redox between Cu2O and CuO bring about the production of H2O2 and hydroxyl radicals [42], leading to the upregulation of Hif-1α. Accordingly, in the copper oxide treated mice, we found in-situ increased expression of pro-angiogenic factors, such as pLGF, Hif-1α and vascular endothelial cell growth factor (VEGF, Fig. 8b) and consequently increased blood vessel formation (p<0.05), as compared to the control treated mice. For more detailed proposed molecular mechanisms of enhanced wound healing by the copper oxide containing wound dressings, please see reference [38].


Using Copper to Improve the Well-Being of the Skin.

Borkow G - Curr Chem Biol (2014)

Increased expression of angiogenic factors and other proteins involved in wound healing. Significantand differential upregulation of mRNA expression of key proteins involved in the wound healing process in thegroup of mice treated with the copper oxide wound dressings as compared to mice treated with control wounddressing without copper. Itgav - Integrin alpha V; and Itgb3 - Integrin beta 3. Data taken from reference [38].
© Copyright Policy - open-access
Related In: Results  -  Collection

License
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Figure 9: Increased expression of angiogenic factors and other proteins involved in wound healing. Significantand differential upregulation of mRNA expression of key proteins involved in the wound healing process in thegroup of mice treated with the copper oxide wound dressings as compared to mice treated with control wounddressing without copper. Itgav - Integrin alpha V; and Itgb3 - Integrin beta 3. Data taken from reference [38].
Mentions: We tested how the continuous application of copper oxide impregnated wound dressing could help heal full thickness skin wounds inflicted in genetically engineered diabetic mice. We found that the wounds healed statistically significantly faster (p<0.01) than wounds treated with control wound dressing without copper or with wound dressing containing silver [38]. Histological analysis revealed normal epidermal and dermal regeneration, granulation tissue formation, formation of numerous new blood vessels, generation of new hair follicles and sebaceous glands, chronic inflammatory infiltrate, and fibroplasia, with no precancerous changes or atypia of any kind (Fig. 8A). mRNA expression analysis of biopsies taken from the wound beds at several days following wounding, revealed significant upregulation of key proteins involved in wound healing in the mice treated with the copper oxide wound dressings as compared to the control mice (Fig. 9). For example, one day after wounding there was ~6 fold increase in integrins (proteins that bind extracellular matrix proteins and transduce signals crucial for cell processes in wound healing [95]) and 22 fold increase in placental growth factor (pLGF; an angiogenic factor known to be markedly reduced in diabetic wounds). Five days after wounding there was a 33, 141 and 112 fold increase in TGF-β1, TGF-β2 and TGF-β3, proteins that stimulate collagen and elastin fiber formation and deposition [4, 6] and are involved in scar formation [7]. Hypoxia-inducible factor-1alpha (Hif-1α) was significantly upregulated by 5 and 88-fold at 5 and 10 days following wounding, respectively. Hif-1α, a regulatory protein involved in oxidative stress [96], activates many genes involved in wound angiogenesis and wound healing [97]. Redox between Cu2O and CuO bring about the production of H2O2 and hydroxyl radicals [42], leading to the upregulation of Hif-1α. Accordingly, in the copper oxide treated mice, we found in-situ increased expression of pro-angiogenic factors, such as pLGF, Hif-1α and vascular endothelial cell growth factor (VEGF, Fig. 8b) and consequently increased blood vessel formation (p<0.05), as compared to the control treated mice. For more detailed proposed molecular mechanisms of enhanced wound healing by the copper oxide containing wound dressings, please see reference [38].

Bottom Line: On the other hand, copper is involved in numerous physiological and metabolic processes critical for the appropriate functioning of almost all tissues in the human body.These include studies showing a) cure of athlete's foot infections and improvement in skin elasticity, especially important for individuals suffering from diabetes; b) reduction of facial fine line and wrinkles; and c) enhancement of wound healing; by copper oxide embedded socks, pillowcases and wound dressings, respectively.The manuscript also reviews and discusses the mechanisms by which the presence of copper in these products improves skin well-being.

View Article: PubMed Central - PubMed

Affiliation: Cupron Inc. Hasadnaot 10, Herzelia, Israel.

ABSTRACT

Copper has two key properties that are being exploited in consumer and medical device products in the last decade. On the one hand, copper has potent biocidal properties. On the other hand, copper is involved in numerous physiological and metabolic processes critical for the appropriate functioning of almost all tissues in the human body. In the skin, copper is involved in the synthesis and stabilization of extracellular matrix skin proteins and angiogenesis. This manuscript reviews clinical studies that show that the use of textile consumer and medical device products, embedded with microscopic copper oxide particles, improve the well-being of the skin. These include studies showing a) cure of athlete's foot infections and improvement in skin elasticity, especially important for individuals suffering from diabetes; b) reduction of facial fine line and wrinkles; and c) enhancement of wound healing; by copper oxide embedded socks, pillowcases and wound dressings, respectively. The manuscript also reviews and discusses the mechanisms by which the presence of copper in these products improves skin well-being.

No MeSH data available.


Related in: MedlinePlus