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Using Copper to Improve the Well-Being of the Skin.

Borkow G - Curr Chem Biol (2014)

Bottom Line: On the other hand, copper is involved in numerous physiological and metabolic processes critical for the appropriate functioning of almost all tissues in the human body.These include studies showing a) cure of athlete's foot infections and improvement in skin elasticity, especially important for individuals suffering from diabetes; b) reduction of facial fine line and wrinkles; and c) enhancement of wound healing; by copper oxide embedded socks, pillowcases and wound dressings, respectively.The manuscript also reviews and discusses the mechanisms by which the presence of copper in these products improves skin well-being.

View Article: PubMed Central - PubMed

Affiliation: Cupron Inc. Hasadnaot 10, Herzelia, Israel.

ABSTRACT

Copper has two key properties that are being exploited in consumer and medical device products in the last decade. On the one hand, copper has potent biocidal properties. On the other hand, copper is involved in numerous physiological and metabolic processes critical for the appropriate functioning of almost all tissues in the human body. In the skin, copper is involved in the synthesis and stabilization of extracellular matrix skin proteins and angiogenesis. This manuscript reviews clinical studies that show that the use of textile consumer and medical device products, embedded with microscopic copper oxide particles, improve the well-being of the skin. These include studies showing a) cure of athlete's foot infections and improvement in skin elasticity, especially important for individuals suffering from diabetes; b) reduction of facial fine line and wrinkles; and c) enhancement of wound healing; by copper oxide embedded socks, pillowcases and wound dressings, respectively. The manuscript also reviews and discusses the mechanisms by which the presence of copper in these products improves skin well-being.

No MeSH data available.


Related in: MedlinePlus

Antibacterial and antifungal efficacy of Cu, Cu++ and Cu+ ions. A)Staphylococcus aureus bacteriawere homogenously plated in agar plates, followed by the addition of Cu, CuO and Cu2O particles (in strips). After24 hours of culture at 37°C the bacteria formed colonies (beige areas). Notice no growth of bacteria especiallyaround the strip of Cu2O particles; B) Cu, CuO and Cu2O particles (in strips) were added to agar plates. A Trichophytonrubrum colony was plated at the side of the plate. The pictures show the growth of the fungi after 4 days ofculture at 37°C. plates without copper served as a negative control. Notice the inhibition of growth of the fungi especiallywhen exposed to the cuprous particles. Experiment was conducted in duplicates.
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Figure 3: Antibacterial and antifungal efficacy of Cu, Cu++ and Cu+ ions. A)Staphylococcus aureus bacteriawere homogenously plated in agar plates, followed by the addition of Cu, CuO and Cu2O particles (in strips). After24 hours of culture at 37°C the bacteria formed colonies (beige areas). Notice no growth of bacteria especiallyaround the strip of Cu2O particles; B) Cu, CuO and Cu2O particles (in strips) were added to agar plates. A Trichophytonrubrum colony was plated at the side of the plate. The pictures show the growth of the fungi after 4 days ofculture at 37°C. plates without copper served as a negative control. Notice the inhibition of growth of the fungi especiallywhen exposed to the cuprous particles. Experiment was conducted in duplicates.

Mentions: Copper can exist in several oxidation states, i.e. metallic copper (Cu0), monovalent copper (Cuprous, Cu+) or divalent copper (cupric, Cu++) ions. Cu+ ions may exhibit more cytotoxic effects with respect to bacteria in comparison to Cu++ ions [70, 71] (Fig. 3A). As shown in Figure 3B, cuprous ions exhibit greater cytotoxicity with respect to fungi. Importantly, redox cycling between Cu++ to Cu+ can catalyze the production of short lived hydroxyl radicals, which in turn may contribute to superior biocidal activity and thus the combined activity of both cuprous and cupric ions provide greater cytocidal activity than either oxidation state alone.


Using Copper to Improve the Well-Being of the Skin.

Borkow G - Curr Chem Biol (2014)

Antibacterial and antifungal efficacy of Cu, Cu++ and Cu+ ions. A)Staphylococcus aureus bacteriawere homogenously plated in agar plates, followed by the addition of Cu, CuO and Cu2O particles (in strips). After24 hours of culture at 37°C the bacteria formed colonies (beige areas). Notice no growth of bacteria especiallyaround the strip of Cu2O particles; B) Cu, CuO and Cu2O particles (in strips) were added to agar plates. A Trichophytonrubrum colony was plated at the side of the plate. The pictures show the growth of the fungi after 4 days ofculture at 37°C. plates without copper served as a negative control. Notice the inhibition of growth of the fungi especiallywhen exposed to the cuprous particles. Experiment was conducted in duplicates.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4556990&req=5

Figure 3: Antibacterial and antifungal efficacy of Cu, Cu++ and Cu+ ions. A)Staphylococcus aureus bacteriawere homogenously plated in agar plates, followed by the addition of Cu, CuO and Cu2O particles (in strips). After24 hours of culture at 37°C the bacteria formed colonies (beige areas). Notice no growth of bacteria especiallyaround the strip of Cu2O particles; B) Cu, CuO and Cu2O particles (in strips) were added to agar plates. A Trichophytonrubrum colony was plated at the side of the plate. The pictures show the growth of the fungi after 4 days ofculture at 37°C. plates without copper served as a negative control. Notice the inhibition of growth of the fungi especiallywhen exposed to the cuprous particles. Experiment was conducted in duplicates.
Mentions: Copper can exist in several oxidation states, i.e. metallic copper (Cu0), monovalent copper (Cuprous, Cu+) or divalent copper (cupric, Cu++) ions. Cu+ ions may exhibit more cytotoxic effects with respect to bacteria in comparison to Cu++ ions [70, 71] (Fig. 3A). As shown in Figure 3B, cuprous ions exhibit greater cytotoxicity with respect to fungi. Importantly, redox cycling between Cu++ to Cu+ can catalyze the production of short lived hydroxyl radicals, which in turn may contribute to superior biocidal activity and thus the combined activity of both cuprous and cupric ions provide greater cytocidal activity than either oxidation state alone.

Bottom Line: On the other hand, copper is involved in numerous physiological and metabolic processes critical for the appropriate functioning of almost all tissues in the human body.These include studies showing a) cure of athlete's foot infections and improvement in skin elasticity, especially important for individuals suffering from diabetes; b) reduction of facial fine line and wrinkles; and c) enhancement of wound healing; by copper oxide embedded socks, pillowcases and wound dressings, respectively.The manuscript also reviews and discusses the mechanisms by which the presence of copper in these products improves skin well-being.

View Article: PubMed Central - PubMed

Affiliation: Cupron Inc. Hasadnaot 10, Herzelia, Israel.

ABSTRACT

Copper has two key properties that are being exploited in consumer and medical device products in the last decade. On the one hand, copper has potent biocidal properties. On the other hand, copper is involved in numerous physiological and metabolic processes critical for the appropriate functioning of almost all tissues in the human body. In the skin, copper is involved in the synthesis and stabilization of extracellular matrix skin proteins and angiogenesis. This manuscript reviews clinical studies that show that the use of textile consumer and medical device products, embedded with microscopic copper oxide particles, improve the well-being of the skin. These include studies showing a) cure of athlete's foot infections and improvement in skin elasticity, especially important for individuals suffering from diabetes; b) reduction of facial fine line and wrinkles; and c) enhancement of wound healing; by copper oxide embedded socks, pillowcases and wound dressings, respectively. The manuscript also reviews and discusses the mechanisms by which the presence of copper in these products improves skin well-being.

No MeSH data available.


Related in: MedlinePlus