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GR3027 antagonizes GABAA receptor-potentiating neurosteroids and restores spatial learning and motor coordination in rats with chronic hyperammonemia and hepatic encephalopathy.

Johansson M, Agusti A, Llansola M, Montoliu C, Strömberg J, Malinina E, Ragagnin G, Doverskog M, Bäckström T, Felipo V - Am. J. Physiol. Gastrointest. Liver Physiol. (2015)

Bottom Line: Current treatments for HE, mainly directed to reduction of ammonia levels, are not effective enough because they cannot completely eliminate hyperammonemia and inflammation, which induce the neurological alterations.Studies in animal models show that overactivation of GABAA receptors is involved in cognitive and motor impairment in HE and that reducing this activation restores these functions.GR3027 is a novel approach to treatment of HE that would normalize neurological functions altered because of enhanced GABAergic tone, affording more complete normalization of cognitive and motor function than current treatments for HE.

View Article: PubMed Central - PubMed

Affiliation: Umecrine Cognition AB, Solna, Sweden; Umeå Neurosteroid Research Center, Department of Clinical Sciences, Umeå University, Umeå, Sweden;

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Scheme showing the experimental design for hyperammonemic (HA; A) rats and portacaval shunt (PCS; B) rats.
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Figure 1: Scheme showing the experimental design for hyperammonemic (HA; A) rats and portacaval shunt (PCS; B) rats.

Mentions: The experimental design, including the treatment period and the time at which the behavioral tests were conducted in the two experimental models, is shown in Fig. 1.


GR3027 antagonizes GABAA receptor-potentiating neurosteroids and restores spatial learning and motor coordination in rats with chronic hyperammonemia and hepatic encephalopathy.

Johansson M, Agusti A, Llansola M, Montoliu C, Strömberg J, Malinina E, Ragagnin G, Doverskog M, Bäckström T, Felipo V - Am. J. Physiol. Gastrointest. Liver Physiol. (2015)

Scheme showing the experimental design for hyperammonemic (HA; A) rats and portacaval shunt (PCS; B) rats.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4556948&req=5

Figure 1: Scheme showing the experimental design for hyperammonemic (HA; A) rats and portacaval shunt (PCS; B) rats.
Mentions: The experimental design, including the treatment period and the time at which the behavioral tests were conducted in the two experimental models, is shown in Fig. 1.

Bottom Line: Current treatments for HE, mainly directed to reduction of ammonia levels, are not effective enough because they cannot completely eliminate hyperammonemia and inflammation, which induce the neurological alterations.Studies in animal models show that overactivation of GABAA receptors is involved in cognitive and motor impairment in HE and that reducing this activation restores these functions.GR3027 is a novel approach to treatment of HE that would normalize neurological functions altered because of enhanced GABAergic tone, affording more complete normalization of cognitive and motor function than current treatments for HE.

View Article: PubMed Central - PubMed

Affiliation: Umecrine Cognition AB, Solna, Sweden; Umeå Neurosteroid Research Center, Department of Clinical Sciences, Umeå University, Umeå, Sweden;

Show MeSH
Related in: MedlinePlus