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Determining factors of diuresis in chronic kidney disease patients initiating hemodialysis.

Nechita AM, Rădulescu D, Peride I, Niculae A, Bratu O, Ferechide D, Ciocâlteu A, Checheriță IA, Mischianu D - J Med Life (2015 Jul-Sep)

Bottom Line: Glomerular etiology, cardiac systolic dysfunction, severe malnutrition, emergency dialysis initiation and lack of permanent vascular access were proved to be associated with significant low diuresis.Age, gender, estimated glomerular filtration rate (GFR) and the presence of systemic hypertension did not influence the amount of daily diuresis.Factors influencing residual diuresis may be distinct from those that influence residual GFR.

View Article: PubMed Central - PubMed

Affiliation: Department of Nephrology and Dialysis, "Sf. Ioan" Clinical Emergency Hospital, Bucharest, Romania.

ABSTRACT

Background: Patients with stage 5 chronic kidney disease (CKD) begin chronic hemodialysis with variable diuresis levels correlated to a comparable low glomerular filtration rate. Residual diuresis influences long-term evolution of the hemodialyzed patient, modifying the prognosis even if optimal Kt/ V is achieved.

Aim of the study: The present study emphasizes the main determining factors of diuresis in a cohort of stage 5 CKD subjects at the beginning of hemodialysis.

Material and methods: 216 patients with stage 5 CKD starting chronic hemodialysis were included in the study, and were grouped according to their residual diuresis: group A (urine output ≤ 500 mL/ day); group B (urine output between 500-1200 mL/ day); group C (urine output ≥ 1200 mL/ day).

Results: Glomerular etiology, cardiac systolic dysfunction, severe malnutrition, emergency dialysis initiation and lack of permanent vascular access were proved to be associated with significant low diuresis. Age, gender, estimated glomerular filtration rate (GFR) and the presence of systemic hypertension did not influence the amount of daily diuresis.

Conclusions: In CKD stage 5 patients, residual diuresis presents large variations in conditions of comparable low GFR. Factors influencing residual diuresis may be distinct from those that influence residual GFR.

No MeSH data available.


Related in: MedlinePlus

Albumin values were significantly lower in group A versus group B and C, respectively
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Figure 11: Albumin values were significantly lower in group A versus group B and C, respectively

Mentions: In patients from group A, plasma albumin values were lower than in the other two groups (T test, Fig. 11, Table 4), and severe malnutrition, defined by decreased plasma albumin < 2.5 g/ dL, was more frequent in group A when compared with the other patients (Z test, Z = 1.50) – Fig. 12.


Determining factors of diuresis in chronic kidney disease patients initiating hemodialysis.

Nechita AM, Rădulescu D, Peride I, Niculae A, Bratu O, Ferechide D, Ciocâlteu A, Checheriță IA, Mischianu D - J Med Life (2015 Jul-Sep)

Albumin values were significantly lower in group A versus group B and C, respectively
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4556923&req=5

Figure 11: Albumin values were significantly lower in group A versus group B and C, respectively
Mentions: In patients from group A, plasma albumin values were lower than in the other two groups (T test, Fig. 11, Table 4), and severe malnutrition, defined by decreased plasma albumin < 2.5 g/ dL, was more frequent in group A when compared with the other patients (Z test, Z = 1.50) – Fig. 12.

Bottom Line: Glomerular etiology, cardiac systolic dysfunction, severe malnutrition, emergency dialysis initiation and lack of permanent vascular access were proved to be associated with significant low diuresis.Age, gender, estimated glomerular filtration rate (GFR) and the presence of systemic hypertension did not influence the amount of daily diuresis.Factors influencing residual diuresis may be distinct from those that influence residual GFR.

View Article: PubMed Central - PubMed

Affiliation: Department of Nephrology and Dialysis, "Sf. Ioan" Clinical Emergency Hospital, Bucharest, Romania.

ABSTRACT

Background: Patients with stage 5 chronic kidney disease (CKD) begin chronic hemodialysis with variable diuresis levels correlated to a comparable low glomerular filtration rate. Residual diuresis influences long-term evolution of the hemodialyzed patient, modifying the prognosis even if optimal Kt/ V is achieved.

Aim of the study: The present study emphasizes the main determining factors of diuresis in a cohort of stage 5 CKD subjects at the beginning of hemodialysis.

Material and methods: 216 patients with stage 5 CKD starting chronic hemodialysis were included in the study, and were grouped according to their residual diuresis: group A (urine output ≤ 500 mL/ day); group B (urine output between 500-1200 mL/ day); group C (urine output ≥ 1200 mL/ day).

Results: Glomerular etiology, cardiac systolic dysfunction, severe malnutrition, emergency dialysis initiation and lack of permanent vascular access were proved to be associated with significant low diuresis. Age, gender, estimated glomerular filtration rate (GFR) and the presence of systemic hypertension did not influence the amount of daily diuresis.

Conclusions: In CKD stage 5 patients, residual diuresis presents large variations in conditions of comparable low GFR. Factors influencing residual diuresis may be distinct from those that influence residual GFR.

No MeSH data available.


Related in: MedlinePlus