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Mucormycosis during Imatinib treatment: case report.

Crisan AM, Ghiaur A, Stancioaca MC, Bardas A, Ghita C, Manea CM, Ionescu B, Coriu D - J Med Life (2015 Jul-Sep)

Bottom Line: After Candida and Aspergillus species, Mucormycosis is the third frequent fungal infection in hematology patients and it is associated with a reduced overall survival.When suspected, immediate treatment is needed.Later, patient refused consolidation and allogeneic hematopoietic stem cell transplant from an unrelated HLA matched donor but accepted the first generation tyrosine kinase inhibitor (Imatinib) and maintained a complete hematological and molecular response.

View Article: PubMed Central - PubMed

Affiliation: Centre of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania ; "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

ABSTRACT

Unlabelled: Philadelphia chromosome positive acute lymphoblastic leukemia is classified as a very high-risk group and it requires an intensive chemotherapy regimen associated with tyrosine-kinase inhibitors and allogeneic hematopoietic stem cell transplant from related or unrelated HLA matched donor. Most times, intensive chemotherapy regimens are associated with prolonged and profound pancytopenia when the risk of invasive fungal infection increases. After Candida and Aspergillus species, Mucormycosis is the third frequent fungal infection in hematology patients and it is associated with a reduced overall survival. When suspected, immediate treatment is needed. We present the case of 24-year-old patient diagnosed with Philadelphia chromosome positive acute lymphoblastic leukemia who developed right rhino-sino-orbital fungal infection with a favorable response to systemic antifungal treatment and noninvasive surgery. Later, patient refused consolidation and allogeneic hematopoietic stem cell transplant from an unrelated HLA matched donor but accepted the first generation tyrosine kinase inhibitor (Imatinib) and maintained a complete hematological and molecular response.

Abbreviations: ENT = ear nose throat; BMB = bone marrow biopsy; ALL = acute lymphoblastic leukemia; TKI = tyrosine kinase inhibitor; IFI = invasive fungal infection; BMB = bone marrow biopsy; HE = hematoxylin and eosin; IHC = immunohistochemistry; CD = cluster of differentiation; ob = objective; Tdt = terminal deoxynucleotidyl transferase.

No MeSH data available.


Related in: MedlinePlus

Right eye – No exophthalmia, no lachrymation, no right eye oedema, no chemosis
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Figure 7: Right eye – No exophthalmia, no lachrymation, no right eye oedema, no chemosis


Mucormycosis during Imatinib treatment: case report.

Crisan AM, Ghiaur A, Stancioaca MC, Bardas A, Ghita C, Manea CM, Ionescu B, Coriu D - J Med Life (2015 Jul-Sep)

Right eye – No exophthalmia, no lachrymation, no right eye oedema, no chemosis
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4556922&req=5

Figure 7: Right eye – No exophthalmia, no lachrymation, no right eye oedema, no chemosis
Bottom Line: After Candida and Aspergillus species, Mucormycosis is the third frequent fungal infection in hematology patients and it is associated with a reduced overall survival.When suspected, immediate treatment is needed.Later, patient refused consolidation and allogeneic hematopoietic stem cell transplant from an unrelated HLA matched donor but accepted the first generation tyrosine kinase inhibitor (Imatinib) and maintained a complete hematological and molecular response.

View Article: PubMed Central - PubMed

Affiliation: Centre of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania ; "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

ABSTRACT

Unlabelled: Philadelphia chromosome positive acute lymphoblastic leukemia is classified as a very high-risk group and it requires an intensive chemotherapy regimen associated with tyrosine-kinase inhibitors and allogeneic hematopoietic stem cell transplant from related or unrelated HLA matched donor. Most times, intensive chemotherapy regimens are associated with prolonged and profound pancytopenia when the risk of invasive fungal infection increases. After Candida and Aspergillus species, Mucormycosis is the third frequent fungal infection in hematology patients and it is associated with a reduced overall survival. When suspected, immediate treatment is needed. We present the case of 24-year-old patient diagnosed with Philadelphia chromosome positive acute lymphoblastic leukemia who developed right rhino-sino-orbital fungal infection with a favorable response to systemic antifungal treatment and noninvasive surgery. Later, patient refused consolidation and allogeneic hematopoietic stem cell transplant from an unrelated HLA matched donor but accepted the first generation tyrosine kinase inhibitor (Imatinib) and maintained a complete hematological and molecular response.

Abbreviations: ENT = ear nose throat; BMB = bone marrow biopsy; ALL = acute lymphoblastic leukemia; TKI = tyrosine kinase inhibitor; IFI = invasive fungal infection; BMB = bone marrow biopsy; HE = hematoxylin and eosin; IHC = immunohistochemistry; CD = cluster of differentiation; ob = objective; Tdt = terminal deoxynucleotidyl transferase.

No MeSH data available.


Related in: MedlinePlus