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Quantification of liver fibrosis in chronic hepatitis B virus infection.

Jieanu CF, Ungureanu BS, Săndulescu DL, Gheonea IA, Tudorașcu DR, Ciurea ME, Purcărea VL - J Med Life (2015 Jul-Sep)

Bottom Line: With liver transplantation as the only viable therapeutic option but only in end-stage disease, hepatitis B progression may generally be influenced by various factors.Several methods have been taken into consideration as an alternative for HBV quantification status, such as imaging techniques and serum based biomarkers.Magnetic resonance imaging, ultrasound, and elastography are considered non-invasive imaging techniques frequently used to quantify disease progression as well as patients future prognostic.

View Article: PubMed Central - PubMed

Affiliation: Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy, Craiova, Romania.

ABSTRACT
Chronic hepatitis B virus infection (HBV) is considered a global public issue with more than 78.000 people per year dying of its evolution. With liver transplantation as the only viable therapeutic option but only in end-stage disease, hepatitis B progression may generally be influenced by various factors. Assessing fibrosis stage plays an important part in future decisions on the patients' wealth with available antiviral agents capable of preventing fibrosis passing to an end-stage liver disease. Several methods have been taken into consideration as an alternative for HBV quantification status, such as imaging techniques and serum based biomarkers. Magnetic resonance imaging, ultrasound, and elastography are considered non-invasive imaging techniques frequently used to quantify disease progression as well as patients future prognostic. Consequently, both direct and indirect biomarkers have been studied for differentiating between fibrosis stages. This paper reviews the current standings in HBV non-invasive liver fibrosis quantification, presenting the prognostic factors and available assessment procedures that might eventually replace liver biopsy.

No MeSH data available.


Related in: MedlinePlus

Transabdominal real-time elastography in a patient with HVB (hard appearance of liver tissue)
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Figure 2: Transabdominal real-time elastography in a patient with HVB (hard appearance of liver tissue)

Mentions: Real time elastography (RTE) is also a useful and promising technique in measuring liver stiffness, which evaluates a shear wave through the liver, while capturing echo signals in real time. Pressure made on the liver tissue translates tissue elasticity as color-related (red - soft tissue, green - intermediate hardness tissue, blue - hard tissue), therefore correlating the region of interest with specific consistency of the desired area (Fig. 1,2).


Quantification of liver fibrosis in chronic hepatitis B virus infection.

Jieanu CF, Ungureanu BS, Săndulescu DL, Gheonea IA, Tudorașcu DR, Ciurea ME, Purcărea VL - J Med Life (2015 Jul-Sep)

Transabdominal real-time elastography in a patient with HVB (hard appearance of liver tissue)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4556907&req=5

Figure 2: Transabdominal real-time elastography in a patient with HVB (hard appearance of liver tissue)
Mentions: Real time elastography (RTE) is also a useful and promising technique in measuring liver stiffness, which evaluates a shear wave through the liver, while capturing echo signals in real time. Pressure made on the liver tissue translates tissue elasticity as color-related (red - soft tissue, green - intermediate hardness tissue, blue - hard tissue), therefore correlating the region of interest with specific consistency of the desired area (Fig. 1,2).

Bottom Line: With liver transplantation as the only viable therapeutic option but only in end-stage disease, hepatitis B progression may generally be influenced by various factors.Several methods have been taken into consideration as an alternative for HBV quantification status, such as imaging techniques and serum based biomarkers.Magnetic resonance imaging, ultrasound, and elastography are considered non-invasive imaging techniques frequently used to quantify disease progression as well as patients future prognostic.

View Article: PubMed Central - PubMed

Affiliation: Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy, Craiova, Romania.

ABSTRACT
Chronic hepatitis B virus infection (HBV) is considered a global public issue with more than 78.000 people per year dying of its evolution. With liver transplantation as the only viable therapeutic option but only in end-stage disease, hepatitis B progression may generally be influenced by various factors. Assessing fibrosis stage plays an important part in future decisions on the patients' wealth with available antiviral agents capable of preventing fibrosis passing to an end-stage liver disease. Several methods have been taken into consideration as an alternative for HBV quantification status, such as imaging techniques and serum based biomarkers. Magnetic resonance imaging, ultrasound, and elastography are considered non-invasive imaging techniques frequently used to quantify disease progression as well as patients future prognostic. Consequently, both direct and indirect biomarkers have been studied for differentiating between fibrosis stages. This paper reviews the current standings in HBV non-invasive liver fibrosis quantification, presenting the prognostic factors and available assessment procedures that might eventually replace liver biopsy.

No MeSH data available.


Related in: MedlinePlus