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Omega-3 Fatty Acids Supplementation in Children to Prevent Asthma: Is It Worthy?-A Systematic Review and Meta-Analysis.

Muley P, Shah M, Muley A - J Allergy (Cairo) (2015)

Bottom Line: Random effects model was used for pooling the risk estimates.Total five articles were included.We concluded that a multicentric RCT is required to assess the effect of omega-3 FA supplementation exclusively to infants or children to predict the best time of omega-3 FA supplementation to prevent asthmatic or wheezing episodes later in life.

View Article: PubMed Central - PubMed

Affiliation: Department of Paediatrics, S.B.K.S MIRC, Sumandeep Vidyapeeth, Vadodara, Gujarat 391760, India.

ABSTRACT
Asthma is one of the most common respiratory diseases affecting all age groups. The world is now trying to identify some dietary factors which can play a preventive role. We performed this systematic review and meta-analysis of RCTs to assess the effect of intake of polyunsaturated fatty acid (PUFA) in infancy and/or childhood on incidence of asthma or wheezing episodes. We searched MEDLINE, EBSCO, Trip, and Google Scholar up to January 31, 2015. All RCTs where infants or children who were given omega-3 fatty acid supplementation and which reported incidence of asthma and/or wheezing episodes as dichotomous outcomes were included in this review. Random effects model was used for pooling the risk estimates. Total five articles were included. Most of them were from Australia. On meta-analysis, the pooled estimate of odds ratios by random effects model showed no significant change in incidence of asthma after supplementation of omega-3 FA in infancy or childhood (OR 0.974; CI 0.646, 1.469; p = 0.900). We concluded that a multicentric RCT is required to assess the effect of omega-3 FA supplementation exclusively to infants or children to predict the best time of omega-3 FA supplementation to prevent asthmatic or wheezing episodes later in life.

No MeSH data available.


Related in: MedlinePlus

Odds ratio and 95% confidence interval of risk of asthma. The pooled estimates were obtained using a random effects model. The squares represent relative risk in each study, with square size representing the study-specific weight and the 95% CI is represented by horizontal bars. The diamond at the bottom indicates summary risk estimate.
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fig2: Odds ratio and 95% confidence interval of risk of asthma. The pooled estimates were obtained using a random effects model. The squares represent relative risk in each study, with square size representing the study-specific weight and the 95% CI is represented by horizontal bars. The diamond at the bottom indicates summary risk estimate.

Mentions: The included studies did not show significant heterogeneity amongst them (I2 = 52.20, Tau2 = 0.109, p = 0.07). On meta-analysis, the pooled estimate of odds ratios by random effects model showed no significant change in incidence of asthma after supplementation of omega-3 FA in infancy or childhood (OR 0.974; CI 0.646, 1.469; p = 0.900) (Figure 2).


Omega-3 Fatty Acids Supplementation in Children to Prevent Asthma: Is It Worthy?-A Systematic Review and Meta-Analysis.

Muley P, Shah M, Muley A - J Allergy (Cairo) (2015)

Odds ratio and 95% confidence interval of risk of asthma. The pooled estimates were obtained using a random effects model. The squares represent relative risk in each study, with square size representing the study-specific weight and the 95% CI is represented by horizontal bars. The diamond at the bottom indicates summary risk estimate.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4556859&req=5

fig2: Odds ratio and 95% confidence interval of risk of asthma. The pooled estimates were obtained using a random effects model. The squares represent relative risk in each study, with square size representing the study-specific weight and the 95% CI is represented by horizontal bars. The diamond at the bottom indicates summary risk estimate.
Mentions: The included studies did not show significant heterogeneity amongst them (I2 = 52.20, Tau2 = 0.109, p = 0.07). On meta-analysis, the pooled estimate of odds ratios by random effects model showed no significant change in incidence of asthma after supplementation of omega-3 FA in infancy or childhood (OR 0.974; CI 0.646, 1.469; p = 0.900) (Figure 2).

Bottom Line: Random effects model was used for pooling the risk estimates.Total five articles were included.We concluded that a multicentric RCT is required to assess the effect of omega-3 FA supplementation exclusively to infants or children to predict the best time of omega-3 FA supplementation to prevent asthmatic or wheezing episodes later in life.

View Article: PubMed Central - PubMed

Affiliation: Department of Paediatrics, S.B.K.S MIRC, Sumandeep Vidyapeeth, Vadodara, Gujarat 391760, India.

ABSTRACT
Asthma is one of the most common respiratory diseases affecting all age groups. The world is now trying to identify some dietary factors which can play a preventive role. We performed this systematic review and meta-analysis of RCTs to assess the effect of intake of polyunsaturated fatty acid (PUFA) in infancy and/or childhood on incidence of asthma or wheezing episodes. We searched MEDLINE, EBSCO, Trip, and Google Scholar up to January 31, 2015. All RCTs where infants or children who were given omega-3 fatty acid supplementation and which reported incidence of asthma and/or wheezing episodes as dichotomous outcomes were included in this review. Random effects model was used for pooling the risk estimates. Total five articles were included. Most of them were from Australia. On meta-analysis, the pooled estimate of odds ratios by random effects model showed no significant change in incidence of asthma after supplementation of omega-3 FA in infancy or childhood (OR 0.974; CI 0.646, 1.469; p = 0.900). We concluded that a multicentric RCT is required to assess the effect of omega-3 FA supplementation exclusively to infants or children to predict the best time of omega-3 FA supplementation to prevent asthmatic or wheezing episodes later in life.

No MeSH data available.


Related in: MedlinePlus