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Preimplantation Exposure to Bisphenol A and Triclosan May Lead to Implantation Failure in Humans.

Yuan M, Bai MZ, Huang XF, Zhang Y, Liu J, Hu MH, Zheng WQ, Jin F - Biomed Res Int (2015)

Bottom Line: Endocrine disrupting chemicals (EDCs) are chemicals that have the capacity to interfere with normal endocrine systems.Two EDCs, bisphenol A (BPA) and triclosan (TCS), are mass-produced and widespread.Studies in mouse models have suggested that preimplantation exposure to BPA and TCS can lead to implantation failure.

View Article: PubMed Central - PubMed

Affiliation: Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou 310006, China.

ABSTRACT
Endocrine disrupting chemicals (EDCs) are chemicals that have the capacity to interfere with normal endocrine systems. Two EDCs, bisphenol A (BPA) and triclosan (TCS), are mass-produced and widespread. They both have estrogenic properties and similar chemical structures and pharmacokinetic features and have been detected in human fluids and tissues. Clinical evidence has suggested a positive association between BPA exposure and implantation failure in IVF patients. Studies in mouse models have suggested that preimplantation exposure to BPA and TCS can lead to implantation failure. This paper reviews the relationship between preimplantation exposure to BPA and TCS and implantation failure and discusses the remaining problems and possible solutions.

No MeSH data available.


Related in: MedlinePlus

Possible mechanism by which BPA and TCS may affect embryo implantation.
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fig2: Possible mechanism by which BPA and TCS may affect embryo implantation.

Mentions: Crawford and deCatanzaro [28] suggested that preimplantation exposure to TCS can also cause implantation failure in mice and that TCS can act in conjunction with BPA. However, the mechanism of this implantation failure in humans and mice is still unknown. The possible mechanism by which the two chemicals may affect embryo implantation is illustrated in Figure 2.


Preimplantation Exposure to Bisphenol A and Triclosan May Lead to Implantation Failure in Humans.

Yuan M, Bai MZ, Huang XF, Zhang Y, Liu J, Hu MH, Zheng WQ, Jin F - Biomed Res Int (2015)

Possible mechanism by which BPA and TCS may affect embryo implantation.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4556842&req=5

fig2: Possible mechanism by which BPA and TCS may affect embryo implantation.
Mentions: Crawford and deCatanzaro [28] suggested that preimplantation exposure to TCS can also cause implantation failure in mice and that TCS can act in conjunction with BPA. However, the mechanism of this implantation failure in humans and mice is still unknown. The possible mechanism by which the two chemicals may affect embryo implantation is illustrated in Figure 2.

Bottom Line: Endocrine disrupting chemicals (EDCs) are chemicals that have the capacity to interfere with normal endocrine systems.Two EDCs, bisphenol A (BPA) and triclosan (TCS), are mass-produced and widespread.Studies in mouse models have suggested that preimplantation exposure to BPA and TCS can lead to implantation failure.

View Article: PubMed Central - PubMed

Affiliation: Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou 310006, China.

ABSTRACT
Endocrine disrupting chemicals (EDCs) are chemicals that have the capacity to interfere with normal endocrine systems. Two EDCs, bisphenol A (BPA) and triclosan (TCS), are mass-produced and widespread. They both have estrogenic properties and similar chemical structures and pharmacokinetic features and have been detected in human fluids and tissues. Clinical evidence has suggested a positive association between BPA exposure and implantation failure in IVF patients. Studies in mouse models have suggested that preimplantation exposure to BPA and TCS can lead to implantation failure. This paper reviews the relationship between preimplantation exposure to BPA and TCS and implantation failure and discusses the remaining problems and possible solutions.

No MeSH data available.


Related in: MedlinePlus