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Preimplantation Exposure to Bisphenol A and Triclosan May Lead to Implantation Failure in Humans.

Yuan M, Bai MZ, Huang XF, Zhang Y, Liu J, Hu MH, Zheng WQ, Jin F - Biomed Res Int (2015)

Bottom Line: Endocrine disrupting chemicals (EDCs) are chemicals that have the capacity to interfere with normal endocrine systems.Two EDCs, bisphenol A (BPA) and triclosan (TCS), are mass-produced and widespread.Studies in mouse models have suggested that preimplantation exposure to BPA and TCS can lead to implantation failure.

View Article: PubMed Central - PubMed

Affiliation: Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou 310006, China.

ABSTRACT
Endocrine disrupting chemicals (EDCs) are chemicals that have the capacity to interfere with normal endocrine systems. Two EDCs, bisphenol A (BPA) and triclosan (TCS), are mass-produced and widespread. They both have estrogenic properties and similar chemical structures and pharmacokinetic features and have been detected in human fluids and tissues. Clinical evidence has suggested a positive association between BPA exposure and implantation failure in IVF patients. Studies in mouse models have suggested that preimplantation exposure to BPA and TCS can lead to implantation failure. This paper reviews the relationship between preimplantation exposure to BPA and TCS and implantation failure and discusses the remaining problems and possible solutions.

No MeSH data available.


Related in: MedlinePlus

Chemical structures of BPA, TCS, and 17β-estradiol.
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fig1: Chemical structures of BPA, TCS, and 17β-estradiol.

Mentions: Some chemicals which have been widely used for decades have recently been found to have the ability to disrupt endocrine function in humans. They are called endocrine disrupting chemicals (EDCs). Bisphenol A (BPA) and triclosan (TCS) are EDCs with similar chemical structures to 17β-estradiol [8] (Figure 1). They have recently been noticed due to their ubiquitous presence in the environment and in human fluids and tissues [9–23]. BPA is the monomer used in the production of polycarbonate plastics and some epoxy resins. It is one of the most-produced chemicals worldwide, with over six billion pounds produced each year [21]. TCS is an antimicrobial additive used in many personal care and household products.


Preimplantation Exposure to Bisphenol A and Triclosan May Lead to Implantation Failure in Humans.

Yuan M, Bai MZ, Huang XF, Zhang Y, Liu J, Hu MH, Zheng WQ, Jin F - Biomed Res Int (2015)

Chemical structures of BPA, TCS, and 17β-estradiol.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4556842&req=5

fig1: Chemical structures of BPA, TCS, and 17β-estradiol.
Mentions: Some chemicals which have been widely used for decades have recently been found to have the ability to disrupt endocrine function in humans. They are called endocrine disrupting chemicals (EDCs). Bisphenol A (BPA) and triclosan (TCS) are EDCs with similar chemical structures to 17β-estradiol [8] (Figure 1). They have recently been noticed due to their ubiquitous presence in the environment and in human fluids and tissues [9–23]. BPA is the monomer used in the production of polycarbonate plastics and some epoxy resins. It is one of the most-produced chemicals worldwide, with over six billion pounds produced each year [21]. TCS is an antimicrobial additive used in many personal care and household products.

Bottom Line: Endocrine disrupting chemicals (EDCs) are chemicals that have the capacity to interfere with normal endocrine systems.Two EDCs, bisphenol A (BPA) and triclosan (TCS), are mass-produced and widespread.Studies in mouse models have suggested that preimplantation exposure to BPA and TCS can lead to implantation failure.

View Article: PubMed Central - PubMed

Affiliation: Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou 310006, China.

ABSTRACT
Endocrine disrupting chemicals (EDCs) are chemicals that have the capacity to interfere with normal endocrine systems. Two EDCs, bisphenol A (BPA) and triclosan (TCS), are mass-produced and widespread. They both have estrogenic properties and similar chemical structures and pharmacokinetic features and have been detected in human fluids and tissues. Clinical evidence has suggested a positive association between BPA exposure and implantation failure in IVF patients. Studies in mouse models have suggested that preimplantation exposure to BPA and TCS can lead to implantation failure. This paper reviews the relationship between preimplantation exposure to BPA and TCS and implantation failure and discusses the remaining problems and possible solutions.

No MeSH data available.


Related in: MedlinePlus