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Association of the NAD(P)H oxidase p22 phox gene C242T polymorphism with type 2 diabetes mellitus, diabetic nephropathy, and carotid atherosclerosis with type 2 diabetes mellitus: A meta-analysis.

Li T, Xi HF, Luo HM, Liu WX, Gao X, Liu DW, Yang L - Meta Gene (2015)

Bottom Line: The results showed a significant association between the NAD(P)H oxidase p22 phox gene C242T polymorphism and T2DM risk in the allelic model (REM: OR = 1.23, 95% CI = 1.06-1.43), additive model (FEM: OR = 1.61, 95% CI = 1.14-2.26), and recessive model (FEM: OR = 1.50, 95% CI = 1.10-2.05).Similar results were obtained in subgroup analysis based on ethnicity.Results of this meta-analysis suggest that the NAD(P)H oxidase p22 phox gene 242T allele might be associated with an increased risk of T2DM and DN, but not CA.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology and Statistic, Hebei Medical University, Shijiazhuang 050017, China.

ABSTRACT

Background: Several epidemiological studies have evaluated the association between the NAD(P)H oxidase p22 phox gene C242T polymorphism and the risk of type 2 diabetes mellitus (T2DM), diabetic nephropathy (DN), and carotid atherosclerosis with T2DM (CA), but the results are inconclusive. This meta-analysis was therefore designed to clarify these controversies.

Methods: Systematic searches were performed using electronic databases such as MEDLINE, PubMed, EMBASE, and China National Knowledge Infrastructure, as well as through manual searching of the references of identified articles. A total of 11 publications were eligible for this meta-analysis after running a search on the NAD(P)H oxidase p22 phox gene C242T polymorphism, including 7 with outcomes for T2DM, 7 with outcomes for DN, and 3 with outcomes for CA. The pooled odds ratio (OR) with a 95% confidence interval (CI) was calculated using a fixed effects model (FEM) or a random effects model (REM). Publication bias was tested by Begg's funnel plot analysis. Sensitivity analysis was also performed.

Results: The results showed a significant association between the NAD(P)H oxidase p22 phox gene C242T polymorphism and T2DM risk in the allelic model (REM: OR = 1.23, 95% CI = 1.06-1.43), additive model (FEM: OR = 1.61, 95% CI = 1.14-2.26), and recessive model (FEM: OR = 1.50, 95% CI = 1.10-2.05). A significant association was also observed for DN in the allelic model (REM: OR = 1.25, 95% CI = 1.06-1.47), additive model (FEM: OR = 1.61, 95% CI = 1.08-2.38), and dominant model (REM: OR = 1.26, 95% CI = 1.03-1.54). However, no association was observed for CA. Similar results were obtained in subgroup analysis based on ethnicity.

Conclusions: Results of this meta-analysis suggest that the NAD(P)H oxidase p22 phox gene 242T allele might be associated with an increased risk of T2DM and DN, but not CA.

No MeSH data available.


Related in: MedlinePlus

Forest plots for the p22 phox gene C242T polymorphism and DN risk. A. allelic model: T allele vs. C allele; B. additive model: TT vs.CC; C. recessive model: TT vs. TC + CC; D. dominant model: TT + T/C vs. C/C.
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f0015: Forest plots for the p22 phox gene C242T polymorphism and DN risk. A. allelic model: T allele vs. C allele; B. additive model: TT vs.CC; C. recessive model: TT vs. TC + CC; D. dominant model: TT + T/C vs. C/C.

Mentions: As shown in Fig. 3 and Table 1, a total of 1068 cases (T2DM patients with DN) and 1026 controls (T2DM patients without DN) were identified for the analysis of the association between the p22 phox gene C242T polymorphism and DN.


Association of the NAD(P)H oxidase p22 phox gene C242T polymorphism with type 2 diabetes mellitus, diabetic nephropathy, and carotid atherosclerosis with type 2 diabetes mellitus: A meta-analysis.

Li T, Xi HF, Luo HM, Liu WX, Gao X, Liu DW, Yang L - Meta Gene (2015)

Forest plots for the p22 phox gene C242T polymorphism and DN risk. A. allelic model: T allele vs. C allele; B. additive model: TT vs.CC; C. recessive model: TT vs. TC + CC; D. dominant model: TT + T/C vs. C/C.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4556815&req=5

f0015: Forest plots for the p22 phox gene C242T polymorphism and DN risk. A. allelic model: T allele vs. C allele; B. additive model: TT vs.CC; C. recessive model: TT vs. TC + CC; D. dominant model: TT + T/C vs. C/C.
Mentions: As shown in Fig. 3 and Table 1, a total of 1068 cases (T2DM patients with DN) and 1026 controls (T2DM patients without DN) were identified for the analysis of the association between the p22 phox gene C242T polymorphism and DN.

Bottom Line: The results showed a significant association between the NAD(P)H oxidase p22 phox gene C242T polymorphism and T2DM risk in the allelic model (REM: OR = 1.23, 95% CI = 1.06-1.43), additive model (FEM: OR = 1.61, 95% CI = 1.14-2.26), and recessive model (FEM: OR = 1.50, 95% CI = 1.10-2.05).Similar results were obtained in subgroup analysis based on ethnicity.Results of this meta-analysis suggest that the NAD(P)H oxidase p22 phox gene 242T allele might be associated with an increased risk of T2DM and DN, but not CA.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology and Statistic, Hebei Medical University, Shijiazhuang 050017, China.

ABSTRACT

Background: Several epidemiological studies have evaluated the association between the NAD(P)H oxidase p22 phox gene C242T polymorphism and the risk of type 2 diabetes mellitus (T2DM), diabetic nephropathy (DN), and carotid atherosclerosis with T2DM (CA), but the results are inconclusive. This meta-analysis was therefore designed to clarify these controversies.

Methods: Systematic searches were performed using electronic databases such as MEDLINE, PubMed, EMBASE, and China National Knowledge Infrastructure, as well as through manual searching of the references of identified articles. A total of 11 publications were eligible for this meta-analysis after running a search on the NAD(P)H oxidase p22 phox gene C242T polymorphism, including 7 with outcomes for T2DM, 7 with outcomes for DN, and 3 with outcomes for CA. The pooled odds ratio (OR) with a 95% confidence interval (CI) was calculated using a fixed effects model (FEM) or a random effects model (REM). Publication bias was tested by Begg's funnel plot analysis. Sensitivity analysis was also performed.

Results: The results showed a significant association between the NAD(P)H oxidase p22 phox gene C242T polymorphism and T2DM risk in the allelic model (REM: OR = 1.23, 95% CI = 1.06-1.43), additive model (FEM: OR = 1.61, 95% CI = 1.14-2.26), and recessive model (FEM: OR = 1.50, 95% CI = 1.10-2.05). A significant association was also observed for DN in the allelic model (REM: OR = 1.25, 95% CI = 1.06-1.47), additive model (FEM: OR = 1.61, 95% CI = 1.08-2.38), and dominant model (REM: OR = 1.26, 95% CI = 1.03-1.54). However, no association was observed for CA. Similar results were obtained in subgroup analysis based on ethnicity.

Conclusions: Results of this meta-analysis suggest that the NAD(P)H oxidase p22 phox gene 242T allele might be associated with an increased risk of T2DM and DN, but not CA.

No MeSH data available.


Related in: MedlinePlus