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Association of the NAD(P)H oxidase p22 phox gene C242T polymorphism with type 2 diabetes mellitus, diabetic nephropathy, and carotid atherosclerosis with type 2 diabetes mellitus: A meta-analysis.

Li T, Xi HF, Luo HM, Liu WX, Gao X, Liu DW, Yang L - Meta Gene (2015)

Bottom Line: The results showed a significant association between the NAD(P)H oxidase p22 phox gene C242T polymorphism and T2DM risk in the allelic model (REM: OR = 1.23, 95% CI = 1.06-1.43), additive model (FEM: OR = 1.61, 95% CI = 1.14-2.26), and recessive model (FEM: OR = 1.50, 95% CI = 1.10-2.05).Similar results were obtained in subgroup analysis based on ethnicity.Results of this meta-analysis suggest that the NAD(P)H oxidase p22 phox gene 242T allele might be associated with an increased risk of T2DM and DN, but not CA.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology and Statistic, Hebei Medical University, Shijiazhuang 050017, China.

ABSTRACT

Background: Several epidemiological studies have evaluated the association between the NAD(P)H oxidase p22 phox gene C242T polymorphism and the risk of type 2 diabetes mellitus (T2DM), diabetic nephropathy (DN), and carotid atherosclerosis with T2DM (CA), but the results are inconclusive. This meta-analysis was therefore designed to clarify these controversies.

Methods: Systematic searches were performed using electronic databases such as MEDLINE, PubMed, EMBASE, and China National Knowledge Infrastructure, as well as through manual searching of the references of identified articles. A total of 11 publications were eligible for this meta-analysis after running a search on the NAD(P)H oxidase p22 phox gene C242T polymorphism, including 7 with outcomes for T2DM, 7 with outcomes for DN, and 3 with outcomes for CA. The pooled odds ratio (OR) with a 95% confidence interval (CI) was calculated using a fixed effects model (FEM) or a random effects model (REM). Publication bias was tested by Begg's funnel plot analysis. Sensitivity analysis was also performed.

Results: The results showed a significant association between the NAD(P)H oxidase p22 phox gene C242T polymorphism and T2DM risk in the allelic model (REM: OR = 1.23, 95% CI = 1.06-1.43), additive model (FEM: OR = 1.61, 95% CI = 1.14-2.26), and recessive model (FEM: OR = 1.50, 95% CI = 1.10-2.05). A significant association was also observed for DN in the allelic model (REM: OR = 1.25, 95% CI = 1.06-1.47), additive model (FEM: OR = 1.61, 95% CI = 1.08-2.38), and dominant model (REM: OR = 1.26, 95% CI = 1.03-1.54). However, no association was observed for CA. Similar results were obtained in subgroup analysis based on ethnicity.

Conclusions: Results of this meta-analysis suggest that the NAD(P)H oxidase p22 phox gene 242T allele might be associated with an increased risk of T2DM and DN, but not CA.

No MeSH data available.


Related in: MedlinePlus

Flowchart of the literature selection process.
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f0005: Flowchart of the literature selection process.

Mentions: Based on our preliminary search criteria, we identified 75 articles during our initial electronic search. In order to assess the appropriateness of the articles, their article abstracts were screened. Fifty articles (review articles, duplicate publications, and articles that were not relevant) were excluded during the initial review. We retrieved the full text for the remaining 25 articles for further evaluation using the inclusion criteria, and a total of 11 publications were found eligible for this meta-analysis (Doi et al. 2005; Hayaishi-Okano et al. 2003; Jin et al., 2011; Letonja et al. 2012; Lim et al. 2006; Liu et al., 2006; Matsunaga-Irie et al. 2004; Narne et al. 2014; Santos et al., 2005; Yan, 2005; Yang et al., 2006), including 7 with outcomes for T2DM, 7 with outcomes for DN, and 3 with outcomes for CA resulting from a search on the NAD(P)H oxidase p22 phox gene C242T polymorphism (Fig. 1). All 11 articles had a case–control design. The Newcastle-Ottawa-Scale (NOS) scores of all included studies were ≥ 5 (data not show). General characteristics and genotype distributions of the above-mentioned three types of associations (T2DM, DN and CA) in the 11 studies are shown in Table 1.


Association of the NAD(P)H oxidase p22 phox gene C242T polymorphism with type 2 diabetes mellitus, diabetic nephropathy, and carotid atherosclerosis with type 2 diabetes mellitus: A meta-analysis.

Li T, Xi HF, Luo HM, Liu WX, Gao X, Liu DW, Yang L - Meta Gene (2015)

Flowchart of the literature selection process.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4556815&req=5

f0005: Flowchart of the literature selection process.
Mentions: Based on our preliminary search criteria, we identified 75 articles during our initial electronic search. In order to assess the appropriateness of the articles, their article abstracts were screened. Fifty articles (review articles, duplicate publications, and articles that were not relevant) were excluded during the initial review. We retrieved the full text for the remaining 25 articles for further evaluation using the inclusion criteria, and a total of 11 publications were found eligible for this meta-analysis (Doi et al. 2005; Hayaishi-Okano et al. 2003; Jin et al., 2011; Letonja et al. 2012; Lim et al. 2006; Liu et al., 2006; Matsunaga-Irie et al. 2004; Narne et al. 2014; Santos et al., 2005; Yan, 2005; Yang et al., 2006), including 7 with outcomes for T2DM, 7 with outcomes for DN, and 3 with outcomes for CA resulting from a search on the NAD(P)H oxidase p22 phox gene C242T polymorphism (Fig. 1). All 11 articles had a case–control design. The Newcastle-Ottawa-Scale (NOS) scores of all included studies were ≥ 5 (data not show). General characteristics and genotype distributions of the above-mentioned three types of associations (T2DM, DN and CA) in the 11 studies are shown in Table 1.

Bottom Line: The results showed a significant association between the NAD(P)H oxidase p22 phox gene C242T polymorphism and T2DM risk in the allelic model (REM: OR = 1.23, 95% CI = 1.06-1.43), additive model (FEM: OR = 1.61, 95% CI = 1.14-2.26), and recessive model (FEM: OR = 1.50, 95% CI = 1.10-2.05).Similar results were obtained in subgroup analysis based on ethnicity.Results of this meta-analysis suggest that the NAD(P)H oxidase p22 phox gene 242T allele might be associated with an increased risk of T2DM and DN, but not CA.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology and Statistic, Hebei Medical University, Shijiazhuang 050017, China.

ABSTRACT

Background: Several epidemiological studies have evaluated the association between the NAD(P)H oxidase p22 phox gene C242T polymorphism and the risk of type 2 diabetes mellitus (T2DM), diabetic nephropathy (DN), and carotid atherosclerosis with T2DM (CA), but the results are inconclusive. This meta-analysis was therefore designed to clarify these controversies.

Methods: Systematic searches were performed using electronic databases such as MEDLINE, PubMed, EMBASE, and China National Knowledge Infrastructure, as well as through manual searching of the references of identified articles. A total of 11 publications were eligible for this meta-analysis after running a search on the NAD(P)H oxidase p22 phox gene C242T polymorphism, including 7 with outcomes for T2DM, 7 with outcomes for DN, and 3 with outcomes for CA. The pooled odds ratio (OR) with a 95% confidence interval (CI) was calculated using a fixed effects model (FEM) or a random effects model (REM). Publication bias was tested by Begg's funnel plot analysis. Sensitivity analysis was also performed.

Results: The results showed a significant association between the NAD(P)H oxidase p22 phox gene C242T polymorphism and T2DM risk in the allelic model (REM: OR = 1.23, 95% CI = 1.06-1.43), additive model (FEM: OR = 1.61, 95% CI = 1.14-2.26), and recessive model (FEM: OR = 1.50, 95% CI = 1.10-2.05). A significant association was also observed for DN in the allelic model (REM: OR = 1.25, 95% CI = 1.06-1.47), additive model (FEM: OR = 1.61, 95% CI = 1.08-2.38), and dominant model (REM: OR = 1.26, 95% CI = 1.03-1.54). However, no association was observed for CA. Similar results were obtained in subgroup analysis based on ethnicity.

Conclusions: Results of this meta-analysis suggest that the NAD(P)H oxidase p22 phox gene 242T allele might be associated with an increased risk of T2DM and DN, but not CA.

No MeSH data available.


Related in: MedlinePlus