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SS-31 attenuates TNF-α induced cytokine release from C2C12 myotubes.

Lightfoot AP, Sakellariou GK, Nye GA, McArdle F, Jackson MJ, Griffiths RD, McArdle A - Redox Biol (2015)

Bottom Line: The aim of this study was to determine the effect of TNF-α on the production of myokines by skeletal muscle.Significant increases were seen in the release of IL-6, MCP-1/CCL2, RANTES/CCL5 and KC/CXCL1 and this release was inhibited by treatment with Brefeldin A, suggesting a golgi-mediated release of cytokines by muscle cells.The changes in superoxide, activation of NF-kB and release of myokines were attenuated following pre-treatment with SS-31 peptide indicating that the ability of TNF-α to induce myokine release may be mediated through mitochondrial superoxide, which is, at least in part, associated with activation of the redox sensitive transcription factor NF-kB.

View Article: PubMed Central - PubMed

Affiliation: MRC-Arthritis UK Centre for Integrated Research into Musculoskeletal Ageing, University of Liverpool, United Kingdom.

No MeSH data available.


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SS-31 attenuates TNF-α induced cytokine release from C2C12 myotubes.

Lightfoot AP, Sakellariou GK, Nye GA, McArdle F, Jackson MJ, Griffiths RD, McArdle A - Redox Biol (2015)

© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4556772&req=5

Bottom Line: The aim of this study was to determine the effect of TNF-α on the production of myokines by skeletal muscle.Significant increases were seen in the release of IL-6, MCP-1/CCL2, RANTES/CCL5 and KC/CXCL1 and this release was inhibited by treatment with Brefeldin A, suggesting a golgi-mediated release of cytokines by muscle cells.The changes in superoxide, activation of NF-kB and release of myokines were attenuated following pre-treatment with SS-31 peptide indicating that the ability of TNF-α to induce myokine release may be mediated through mitochondrial superoxide, which is, at least in part, associated with activation of the redox sensitive transcription factor NF-kB.

View Article: PubMed Central - PubMed

Affiliation: MRC-Arthritis UK Centre for Integrated Research into Musculoskeletal Ageing, University of Liverpool, United Kingdom.

No MeSH data available.