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Dual roles of nitric oxide in the regulation of tumor cell response and resistance to photodynamic therapy.

Rapozzi V, Della Pietra E, Bonavida B - Redox Biol (2015)

Bottom Line: PDT treatment results in the induction of iNOS/NO in both the tumor and the microenvironment.The cytoprotective effect of PDT-induced NO was the result of low levels of NO that activates the pro-survival/anti-apoptotic NF-κB, Snail, and YY1 and inhibits the anti-survival/pro-apoptotic and metastasis suppressor RKIP.In addition, the study suggested that the combination of PDT with subtoxic cytotoxic drugs will result in significant synergy since NO has been shown to be a significant chemo-immunosensitizing agent to apoptosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical and Biological Sciences, University of Udine, P.le Kolbe 4, 33100 Udine, Italy. Electronic address: valentina.rapozzi@uniud.it.

No MeSH data available.


Related in: MedlinePlus

Cytoprotective role of PDT-induced NO.
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f0005: Cytoprotective role of PDT-induced NO.

Mentions: Overall, the above findings demonstrated clearly that the NO-induced by PDT plays a pivotal role in PDT-induced cytoxicity and that the addition of exogenous NO potentiated the cytotoxic activity against the tumor cells. A schematic diagram representing PDT-induced NO-mediated cytotoxity is shown in Fig. 1.


Dual roles of nitric oxide in the regulation of tumor cell response and resistance to photodynamic therapy.

Rapozzi V, Della Pietra E, Bonavida B - Redox Biol (2015)

Cytoprotective role of PDT-induced NO.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4556768&req=5

f0005: Cytoprotective role of PDT-induced NO.
Mentions: Overall, the above findings demonstrated clearly that the NO-induced by PDT plays a pivotal role in PDT-induced cytoxicity and that the addition of exogenous NO potentiated the cytotoxic activity against the tumor cells. A schematic diagram representing PDT-induced NO-mediated cytotoxity is shown in Fig. 1.

Bottom Line: PDT treatment results in the induction of iNOS/NO in both the tumor and the microenvironment.The cytoprotective effect of PDT-induced NO was the result of low levels of NO that activates the pro-survival/anti-apoptotic NF-κB, Snail, and YY1 and inhibits the anti-survival/pro-apoptotic and metastasis suppressor RKIP.In addition, the study suggested that the combination of PDT with subtoxic cytotoxic drugs will result in significant synergy since NO has been shown to be a significant chemo-immunosensitizing agent to apoptosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical and Biological Sciences, University of Udine, P.le Kolbe 4, 33100 Udine, Italy. Electronic address: valentina.rapozzi@uniud.it.

No MeSH data available.


Related in: MedlinePlus