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Evaluation of the effect of physical variables on in vitro release of diclofenac pellets using Box-Behnken design.

Enayatifard R, Mahjoob A, Ebrahimi P, Ebrahimnejad P - Iran J Basic Med Sci (2015)

Bottom Line: Increasing the plasticizer in the coating formula led to decrease in drug release and increasing the curing temperature and time resulted in higher drug release.The level of plasticizer concentration, curing temperature and time were 20% w/w, 55 °C and 24 hr, respectively.This study showed that by controllinig the physical variables optimum drug release were obtained.

View Article: PubMed Central - PubMed

Affiliation: Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran ; Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.

ABSTRACT

Objectives: A Box-Behnken design was used for evaluation of Eudragit coated diclofenac pellets. The purpose of this work was to optimize diclofenac pellets to improve the physicochemical properties using experimental design.

Materials and methods: Diclofenac was loaded onto the non-pareil beads using conventional coating pan. Film coating of pellets was done at the same pan. The effect of plasticizer level, curing temperature and curing time was determined on the release of diclofenac from pellets coated with polymethacrylates.

Results: Increasing the plasticizer in the coating formula led to decrease in drug release and increasing the curing temperature and time resulted in higher drug release. The optimization process generated an optimum of 35% drug release at 3 hr. The level of plasticizer concentration, curing temperature and time were 20% w/w, 55 °C and 24 hr, respectively.

Conclusion: This study showed that by controllinig the physical variables optimum drug release were obtained.

No MeSH data available.


SEM of pellets containing 20% plasticizer, cured at 60 °C for 168 rh with a magnification 999 × (S2)
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Figure 5: SEM of pellets containing 20% plasticizer, cured at 60 °C for 168 rh with a magnification 999 × (S2)

Mentions: The surface morphology of pellets cured at 40 °C for 24 hr (S1) as shown in Figure 2a is smooth and uniform. Surface morphology of the pellets cured at 60 °C for 168 hr (S2) as shown in Figure 2b, is rough and small pores and voids could be observed.


Evaluation of the effect of physical variables on in vitro release of diclofenac pellets using Box-Behnken design.

Enayatifard R, Mahjoob A, Ebrahimi P, Ebrahimnejad P - Iran J Basic Med Sci (2015)

SEM of pellets containing 20% plasticizer, cured at 60 °C for 168 rh with a magnification 999 × (S2)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4556766&req=5

Figure 5: SEM of pellets containing 20% plasticizer, cured at 60 °C for 168 rh with a magnification 999 × (S2)
Mentions: The surface morphology of pellets cured at 40 °C for 24 hr (S1) as shown in Figure 2a is smooth and uniform. Surface morphology of the pellets cured at 60 °C for 168 hr (S2) as shown in Figure 2b, is rough and small pores and voids could be observed.

Bottom Line: Increasing the plasticizer in the coating formula led to decrease in drug release and increasing the curing temperature and time resulted in higher drug release.The level of plasticizer concentration, curing temperature and time were 20% w/w, 55 °C and 24 hr, respectively.This study showed that by controllinig the physical variables optimum drug release were obtained.

View Article: PubMed Central - PubMed

Affiliation: Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran ; Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.

ABSTRACT

Objectives: A Box-Behnken design was used for evaluation of Eudragit coated diclofenac pellets. The purpose of this work was to optimize diclofenac pellets to improve the physicochemical properties using experimental design.

Materials and methods: Diclofenac was loaded onto the non-pareil beads using conventional coating pan. Film coating of pellets was done at the same pan. The effect of plasticizer level, curing temperature and curing time was determined on the release of diclofenac from pellets coated with polymethacrylates.

Results: Increasing the plasticizer in the coating formula led to decrease in drug release and increasing the curing temperature and time resulted in higher drug release. The optimization process generated an optimum of 35% drug release at 3 hr. The level of plasticizer concentration, curing temperature and time were 20% w/w, 55 °C and 24 hr, respectively.

Conclusion: This study showed that by controllinig the physical variables optimum drug release were obtained.

No MeSH data available.