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Evaluation of the effect of physical variables on in vitro release of diclofenac pellets using Box-Behnken design.

Enayatifard R, Mahjoob A, Ebrahimi P, Ebrahimnejad P - Iran J Basic Med Sci (2015)

Bottom Line: Increasing the plasticizer in the coating formula led to decrease in drug release and increasing the curing temperature and time resulted in higher drug release.The level of plasticizer concentration, curing temperature and time were 20% w/w, 55 °C and 24 hr, respectively.This study showed that by controllinig the physical variables optimum drug release were obtained.

View Article: PubMed Central - PubMed

Affiliation: Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran ; Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.

ABSTRACT

Objectives: A Box-Behnken design was used for evaluation of Eudragit coated diclofenac pellets. The purpose of this work was to optimize diclofenac pellets to improve the physicochemical properties using experimental design.

Materials and methods: Diclofenac was loaded onto the non-pareil beads using conventional coating pan. Film coating of pellets was done at the same pan. The effect of plasticizer level, curing temperature and curing time was determined on the release of diclofenac from pellets coated with polymethacrylates.

Results: Increasing the plasticizer in the coating formula led to decrease in drug release and increasing the curing temperature and time resulted in higher drug release. The optimization process generated an optimum of 35% drug release at 3 hr. The level of plasticizer concentration, curing temperature and time were 20% w/w, 55 °C and 24 hr, respectively.

Conclusion: This study showed that by controllinig the physical variables optimum drug release were obtained.

No MeSH data available.


Dissolution profiles of diclofenac sustained release pellets according to the Box-Behnken design (runs 11–15)
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Figure 3: Dissolution profiles of diclofenac sustained release pellets according to the Box-Behnken design (runs 11–15)

Mentions: Dissolution profiles of all 15 formulations are shown in Figures 1a, 1b and 1c. All formulations demonstrated a release of less than 10 percent in acidic medium while in buffer phosphate medium more than 60 percent of drug released.


Evaluation of the effect of physical variables on in vitro release of diclofenac pellets using Box-Behnken design.

Enayatifard R, Mahjoob A, Ebrahimi P, Ebrahimnejad P - Iran J Basic Med Sci (2015)

Dissolution profiles of diclofenac sustained release pellets according to the Box-Behnken design (runs 11–15)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4556766&req=5

Figure 3: Dissolution profiles of diclofenac sustained release pellets according to the Box-Behnken design (runs 11–15)
Mentions: Dissolution profiles of all 15 formulations are shown in Figures 1a, 1b and 1c. All formulations demonstrated a release of less than 10 percent in acidic medium while in buffer phosphate medium more than 60 percent of drug released.

Bottom Line: Increasing the plasticizer in the coating formula led to decrease in drug release and increasing the curing temperature and time resulted in higher drug release.The level of plasticizer concentration, curing temperature and time were 20% w/w, 55 °C and 24 hr, respectively.This study showed that by controllinig the physical variables optimum drug release were obtained.

View Article: PubMed Central - PubMed

Affiliation: Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran ; Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.

ABSTRACT

Objectives: A Box-Behnken design was used for evaluation of Eudragit coated diclofenac pellets. The purpose of this work was to optimize diclofenac pellets to improve the physicochemical properties using experimental design.

Materials and methods: Diclofenac was loaded onto the non-pareil beads using conventional coating pan. Film coating of pellets was done at the same pan. The effect of plasticizer level, curing temperature and curing time was determined on the release of diclofenac from pellets coated with polymethacrylates.

Results: Increasing the plasticizer in the coating formula led to decrease in drug release and increasing the curing temperature and time resulted in higher drug release. The optimization process generated an optimum of 35% drug release at 3 hr. The level of plasticizer concentration, curing temperature and time were 20% w/w, 55 °C and 24 hr, respectively.

Conclusion: This study showed that by controllinig the physical variables optimum drug release were obtained.

No MeSH data available.