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Meta-analysis of cytomegalovirus seroprevalence in volunteer blood donors and healthy subjects in Iran from 1992 to 2013.

Shaiegan M, Rasouli M, Zadsar M, Zolfaghari S - Iran J Basic Med Sci (2015)

Bottom Line: The heterogeneity between selected studies was 97% with an I(2) statistic.In this study a random effects model was used for meta-analysis.The prevalence of CMV IgG and CMV IgM antibodies in the country were estimated to be 92% (95% CI: 90-94) and 2.6% (95% CI: 1.7-3.6), respectively.

View Article: PubMed Central - PubMed

Affiliation: Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Immunohematology Department, Tehran, Iran.

ABSTRACT

Objectives: Human cytomegalovirus (CMV), a double-strand DNA herpesvirus, can be transmitted via blood transfusion which is especially important for immunocompromised recipients and can cause a fatal infection. CMV seroprevalence in Iran was studied on blood donors, healthy subjects, and some patients. Highly variable rates were detected. The purpose of this study was to review CMV seroprevalence in blood donors and apparently healthy individuals, in Iran.

Materials and methods: One hundred and fifty-eight electronic and paper-based resources and databases including published articles in internal and external journals, seminars, dissertations, and theses available in the database and different websites were used to be systematically reviewed as a meta-analysis. Less related articles to the issue, papers of specific high risk population, and articles with not enough information, were excluded. Eventually 22 articles that satisfied our selection criteria were systematically reviewed and analyzed. To explore heterogeneity between studies the I square (I(2)) index was used. Data were analyzed using the statistical software package (STATA) 11.

Results: The heterogeneity between selected studies was 97% with an I(2) statistic. In this study a random effects model was used for meta-analysis. The prevalence of CMV IgG and CMV IgM antibodies in the country were estimated to be 92% (95% CI: 90-94) and 2.6% (95% CI: 1.7-3.6), respectively.

Conclusion: Given high rate of CMV seropositivity in Iran, it seems that CMVAbs screening would not be a reasonable and affordable approach to prevent CMV infection via transfusion especially for immune compromised recipients, so alternative strategies should be considered.

No MeSH data available.


Related in: MedlinePlus

Forest plot of cytomegalovirus IgG antibody prevalence for random effects meta-analysis. Confidence interval (CI)
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Figure 1: Forest plot of cytomegalovirus IgG antibody prevalence for random effects meta-analysis. Confidence interval (CI)

Mentions: The prevalence of CMV IgG using the random effects model in Iranian blood donors and healthy individuals was 92% (95% CI: 90-94) (Figure 1).


Meta-analysis of cytomegalovirus seroprevalence in volunteer blood donors and healthy subjects in Iran from 1992 to 2013.

Shaiegan M, Rasouli M, Zadsar M, Zolfaghari S - Iran J Basic Med Sci (2015)

Forest plot of cytomegalovirus IgG antibody prevalence for random effects meta-analysis. Confidence interval (CI)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4556753&req=5

Figure 1: Forest plot of cytomegalovirus IgG antibody prevalence for random effects meta-analysis. Confidence interval (CI)
Mentions: The prevalence of CMV IgG using the random effects model in Iranian blood donors and healthy individuals was 92% (95% CI: 90-94) (Figure 1).

Bottom Line: The heterogeneity between selected studies was 97% with an I(2) statistic.In this study a random effects model was used for meta-analysis.The prevalence of CMV IgG and CMV IgM antibodies in the country were estimated to be 92% (95% CI: 90-94) and 2.6% (95% CI: 1.7-3.6), respectively.

View Article: PubMed Central - PubMed

Affiliation: Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Immunohematology Department, Tehran, Iran.

ABSTRACT

Objectives: Human cytomegalovirus (CMV), a double-strand DNA herpesvirus, can be transmitted via blood transfusion which is especially important for immunocompromised recipients and can cause a fatal infection. CMV seroprevalence in Iran was studied on blood donors, healthy subjects, and some patients. Highly variable rates were detected. The purpose of this study was to review CMV seroprevalence in blood donors and apparently healthy individuals, in Iran.

Materials and methods: One hundred and fifty-eight electronic and paper-based resources and databases including published articles in internal and external journals, seminars, dissertations, and theses available in the database and different websites were used to be systematically reviewed as a meta-analysis. Less related articles to the issue, papers of specific high risk population, and articles with not enough information, were excluded. Eventually 22 articles that satisfied our selection criteria were systematically reviewed and analyzed. To explore heterogeneity between studies the I square (I(2)) index was used. Data were analyzed using the statistical software package (STATA) 11.

Results: The heterogeneity between selected studies was 97% with an I(2) statistic. In this study a random effects model was used for meta-analysis. The prevalence of CMV IgG and CMV IgM antibodies in the country were estimated to be 92% (95% CI: 90-94) and 2.6% (95% CI: 1.7-3.6), respectively.

Conclusion: Given high rate of CMV seropositivity in Iran, it seems that CMVAbs screening would not be a reasonable and affordable approach to prevent CMV infection via transfusion especially for immune compromised recipients, so alternative strategies should be considered.

No MeSH data available.


Related in: MedlinePlus