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Mental illness, challenging behaviour, and psychotropic drug prescribing in people with intellectual disability: UK population based cohort study.

Sheehan R, Hassiotis A, Walters K, Osborn D, Strydom A, Horsfall L - BMJ (2015)

Bottom Line: New prescriptions of mood stabilisers also decreased significantly.The rate of new antipsychotic prescribing was significantly higher in people with challenging behaviour (incidence rate ratio 2.08, 95% confidence interval 1.90 to 2.27; P<0.001), autism (1.79, 1.56 to 2.04; P<0.001), and dementia (1.42, 1.12 to 1.81; P<0.003) and in those of older age, after control for other sociodemographic factors and comorbidity.More evidence is needed of the efficacy and safety of psychotropic drugs in this group, particularly when they are used for challenging behaviour.

View Article: PubMed Central - PubMed

Affiliation: Division of Psychiatry, University College London, London W1T 7NF, UK r.sheehan@ucl.ac.uk.

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Fig 3 Relations between recorded severe mental illness, challenging behaviour, and prescription of antipsychotic drugs in adults with intellectual disability
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fig3: Fig 3 Relations between recorded severe mental illness, challenging behaviour, and prescription of antipsychotic drugs in adults with intellectual disability

Mentions: Figure 3 shows the overlap between people with a record of severe mental illness, challenging behaviour, and prescription of antipsychotics. Of 9135 peoples treated with antipsychotic drugs by the end of follow-up, 6503 (71%) did not have a record of severe mental illness. Of the 11 915 with a record of challenging behaviour, 5562 (47%) had received antipsychotic drugs, whereas only 1421 (12%) had a record of severe mental illness. Of those with a record of prescription of antipsychotics, 2362 (26%) did not have a record of severe mental illness or challenging behaviour. Further detail of the overlap between challenging behaviour, prescription of antipsychotics, and neuropsychiatric diagnoses is given in web appendix B.


Mental illness, challenging behaviour, and psychotropic drug prescribing in people with intellectual disability: UK population based cohort study.

Sheehan R, Hassiotis A, Walters K, Osborn D, Strydom A, Horsfall L - BMJ (2015)

Fig 3 Relations between recorded severe mental illness, challenging behaviour, and prescription of antipsychotic drugs in adults with intellectual disability
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4556752&req=5

fig3: Fig 3 Relations between recorded severe mental illness, challenging behaviour, and prescription of antipsychotic drugs in adults with intellectual disability
Mentions: Figure 3 shows the overlap between people with a record of severe mental illness, challenging behaviour, and prescription of antipsychotics. Of 9135 peoples treated with antipsychotic drugs by the end of follow-up, 6503 (71%) did not have a record of severe mental illness. Of the 11 915 with a record of challenging behaviour, 5562 (47%) had received antipsychotic drugs, whereas only 1421 (12%) had a record of severe mental illness. Of those with a record of prescription of antipsychotics, 2362 (26%) did not have a record of severe mental illness or challenging behaviour. Further detail of the overlap between challenging behaviour, prescription of antipsychotics, and neuropsychiatric diagnoses is given in web appendix B.

Bottom Line: New prescriptions of mood stabilisers also decreased significantly.The rate of new antipsychotic prescribing was significantly higher in people with challenging behaviour (incidence rate ratio 2.08, 95% confidence interval 1.90 to 2.27; P<0.001), autism (1.79, 1.56 to 2.04; P<0.001), and dementia (1.42, 1.12 to 1.81; P<0.003) and in those of older age, after control for other sociodemographic factors and comorbidity.More evidence is needed of the efficacy and safety of psychotropic drugs in this group, particularly when they are used for challenging behaviour.

View Article: PubMed Central - PubMed

Affiliation: Division of Psychiatry, University College London, London W1T 7NF, UK r.sheehan@ucl.ac.uk.

Show MeSH
Related in: MedlinePlus