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Mental illness, challenging behaviour, and psychotropic drug prescribing in people with intellectual disability: UK population based cohort study.

Sheehan R, Hassiotis A, Walters K, Osborn D, Strydom A, Horsfall L - BMJ (2015)

Bottom Line: New prescriptions of mood stabilisers also decreased significantly.The rate of new antipsychotic prescribing was significantly higher in people with challenging behaviour (incidence rate ratio 2.08, 95% confidence interval 1.90 to 2.27; P<0.001), autism (1.79, 1.56 to 2.04; P<0.001), and dementia (1.42, 1.12 to 1.81; P<0.003) and in those of older age, after control for other sociodemographic factors and comorbidity.More evidence is needed of the efficacy and safety of psychotropic drugs in this group, particularly when they are used for challenging behaviour.

View Article: PubMed Central - PubMed

Affiliation: Division of Psychiatry, University College London, London W1T 7NF, UK r.sheehan@ucl.ac.uk.

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Fig 2 Time trends in new prescriptions of psychotropic drugs in adults with intellectual disability in UK primary care, 1999-2013
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fig2: Fig 2 Time trends in new prescriptions of psychotropic drugs in adults with intellectual disability in UK primary care, 1999-2013

Mentions: Prescription of antipsychotics fell by 4% (3% to 5%; P<0.001) per year over the course of the study period, and the prescription of mood stabilisers also decreased by 4% (3% to 6%; P<0.001) per year. We found no significant time trends in the prescription of other classes of psychotropic drugs (fig 2). Prescription of antidepressants fell significantly in 2005, but rates of prescription in 2013 were similar to those seen at the start of the observation period in 1999.


Mental illness, challenging behaviour, and psychotropic drug prescribing in people with intellectual disability: UK population based cohort study.

Sheehan R, Hassiotis A, Walters K, Osborn D, Strydom A, Horsfall L - BMJ (2015)

Fig 2 Time trends in new prescriptions of psychotropic drugs in adults with intellectual disability in UK primary care, 1999-2013
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4556752&req=5

fig2: Fig 2 Time trends in new prescriptions of psychotropic drugs in adults with intellectual disability in UK primary care, 1999-2013
Mentions: Prescription of antipsychotics fell by 4% (3% to 5%; P<0.001) per year over the course of the study period, and the prescription of mood stabilisers also decreased by 4% (3% to 6%; P<0.001) per year. We found no significant time trends in the prescription of other classes of psychotropic drugs (fig 2). Prescription of antidepressants fell significantly in 2005, but rates of prescription in 2013 were similar to those seen at the start of the observation period in 1999.

Bottom Line: New prescriptions of mood stabilisers also decreased significantly.The rate of new antipsychotic prescribing was significantly higher in people with challenging behaviour (incidence rate ratio 2.08, 95% confidence interval 1.90 to 2.27; P<0.001), autism (1.79, 1.56 to 2.04; P<0.001), and dementia (1.42, 1.12 to 1.81; P<0.003) and in those of older age, after control for other sociodemographic factors and comorbidity.More evidence is needed of the efficacy and safety of psychotropic drugs in this group, particularly when they are used for challenging behaviour.

View Article: PubMed Central - PubMed

Affiliation: Division of Psychiatry, University College London, London W1T 7NF, UK r.sheehan@ucl.ac.uk.

Show MeSH
Related in: MedlinePlus