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Neural signal during immediate reward anticipation in schizophrenia: Relationship to real-world motivation and function.

Subramaniam K, Hooker CI, Biagianti B, Fisher M, Nagarajan S, Vinogradov S - Neuroimage Clin (2015)

Bottom Line: In healthy comparison (HC) participants, reward anticipation is associated with activity in frontal-striatal networks.SZ patients showed hypoactivation in ventral striatum during reward anticipation.Additionally, we found distinct differences between HC and SZ groups in their association between reward-related immediate anticipatory neural activity and their reported experience of pleasure.

View Article: PubMed Central - PubMed

Affiliation: San Francisco Department of Veterans Affairs Medical Center, Department of Psychiatry, University of California, San Francisco, CA 94121, USA.

ABSTRACT
Amotivation in schizophrenia is a central predictor of poor functioning, and is thought to occur due to deficits in anticipating future rewards, suggesting that impairments in anticipating pleasure can contribute to functional disability in schizophrenia. In healthy comparison (HC) participants, reward anticipation is associated with activity in frontal-striatal networks. By contrast, schizophrenia (SZ) participants show hypoactivation within these frontal-striatal networks during this motivated anticipatory brain state. Here, we examined neural activation in SZ and HC participants during the anticipatory phase of stimuli that predicted immediate upcoming reward and punishment, and during the feedback/outcome phase, in relation to trait measures of hedonic pleasure and real-world functional capacity. SZ patients showed hypoactivation in ventral striatum during reward anticipation. Additionally, we found distinct differences between HC and SZ groups in their association between reward-related immediate anticipatory neural activity and their reported experience of pleasure. HC participants recruited reward-related regions in striatum that significantly correlated with subjective consummatory pleasure, while SZ patients revealed activation in attention-related regions, such as the IPL, which correlated with consummatory pleasure and functional capacity. These findings may suggest that SZ patients activate compensatory attention processes during anticipation of immediate upcoming rewards, which likely contribute to their functional capacity in daily life.

No MeSH data available.


Related in: MedlinePlus

Behavior: Mean accuracy in HC and SZ participants. A. One-way ANOVA reveals a significant group difference in overall accuracy.B. One-way ANOVAs reveal a significant group difference in the No Lose condition as well as in the Win condition.
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f0010: Behavior: Mean accuracy in HC and SZ participants. A. One-way ANOVA reveals a significant group difference in overall accuracy.B. One-way ANOVAs reveal a significant group difference in the No Lose condition as well as in the Win condition.

Mentions: We first conducted between-group one-way ANOVAs in SPSS to examine between-group differences for overall accuracy (only correct trials) and RT (for both correct and incorrect trials) (Fig. 2). Correct trials only applied to the Win and No-Lose conditions. We next conducted between-group 2 × 2 repeated-measures ANOVA on accuracy to examine the main effects of condition (Win/No-Lose accuracy), main effects of group (HC/SZ), and group by condition (Win/No-Lose) interaction effects. We also conducted between-group 2 × 3 repeated-measures ANOVA on overall RT to examine the main effects of condition (Win/No-Lose/Null RT), main effects of group (HC/SZ), and group by condition (i.e., Win/No-Lose/Null) interaction effects.


Neural signal during immediate reward anticipation in schizophrenia: Relationship to real-world motivation and function.

Subramaniam K, Hooker CI, Biagianti B, Fisher M, Nagarajan S, Vinogradov S - Neuroimage Clin (2015)

Behavior: Mean accuracy in HC and SZ participants. A. One-way ANOVA reveals a significant group difference in overall accuracy.B. One-way ANOVAs reveal a significant group difference in the No Lose condition as well as in the Win condition.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4556736&req=5

f0010: Behavior: Mean accuracy in HC and SZ participants. A. One-way ANOVA reveals a significant group difference in overall accuracy.B. One-way ANOVAs reveal a significant group difference in the No Lose condition as well as in the Win condition.
Mentions: We first conducted between-group one-way ANOVAs in SPSS to examine between-group differences for overall accuracy (only correct trials) and RT (for both correct and incorrect trials) (Fig. 2). Correct trials only applied to the Win and No-Lose conditions. We next conducted between-group 2 × 2 repeated-measures ANOVA on accuracy to examine the main effects of condition (Win/No-Lose accuracy), main effects of group (HC/SZ), and group by condition (Win/No-Lose) interaction effects. We also conducted between-group 2 × 3 repeated-measures ANOVA on overall RT to examine the main effects of condition (Win/No-Lose/Null RT), main effects of group (HC/SZ), and group by condition (i.e., Win/No-Lose/Null) interaction effects.

Bottom Line: In healthy comparison (HC) participants, reward anticipation is associated with activity in frontal-striatal networks.SZ patients showed hypoactivation in ventral striatum during reward anticipation.Additionally, we found distinct differences between HC and SZ groups in their association between reward-related immediate anticipatory neural activity and their reported experience of pleasure.

View Article: PubMed Central - PubMed

Affiliation: San Francisco Department of Veterans Affairs Medical Center, Department of Psychiatry, University of California, San Francisco, CA 94121, USA.

ABSTRACT
Amotivation in schizophrenia is a central predictor of poor functioning, and is thought to occur due to deficits in anticipating future rewards, suggesting that impairments in anticipating pleasure can contribute to functional disability in schizophrenia. In healthy comparison (HC) participants, reward anticipation is associated with activity in frontal-striatal networks. By contrast, schizophrenia (SZ) participants show hypoactivation within these frontal-striatal networks during this motivated anticipatory brain state. Here, we examined neural activation in SZ and HC participants during the anticipatory phase of stimuli that predicted immediate upcoming reward and punishment, and during the feedback/outcome phase, in relation to trait measures of hedonic pleasure and real-world functional capacity. SZ patients showed hypoactivation in ventral striatum during reward anticipation. Additionally, we found distinct differences between HC and SZ groups in their association between reward-related immediate anticipatory neural activity and their reported experience of pleasure. HC participants recruited reward-related regions in striatum that significantly correlated with subjective consummatory pleasure, while SZ patients revealed activation in attention-related regions, such as the IPL, which correlated with consummatory pleasure and functional capacity. These findings may suggest that SZ patients activate compensatory attention processes during anticipation of immediate upcoming rewards, which likely contribute to their functional capacity in daily life.

No MeSH data available.


Related in: MedlinePlus