Limits...
Normalization of aberrant resting state functional connectivity in fibromyalgia patients following a three month physical exercise therapy.

Flodin P, Martinsen S, Mannerkorpi K, Löfgren M, Bileviciute-Ljungar I, Kosek E, Fransson P - Neuroimage Clin (2015)

Bottom Line: However, little is known about the neurophysiological mechanisms mediating these effects.Our results suggest that previously observed aberrant intrinsic brain connectivity patterns in FM are partly normalized by the physical exercise therapy.However, none of the observed normalizations in intrinsic brain connectivity were significantly correlated with symptom changes.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

ABSTRACT
Physical exercise is one of the most efficient interventions to mitigate chronic pain symptoms in fibromyalgia (FM). However, little is known about the neurophysiological mechanisms mediating these effects. In this study we investigated resting-state connectivity using functional magnetic resonance imaging (fMRI) before and after a 15 week standardized exercise program supervised by physical therapists. Our aim was to gain an understanding of how physical exercise influences previously shown aberrant patterns of intrinsic brain activity in FM. Fourteen FM patients and eleven healthy controls successfully completed the physical exercise treatment. We investigated post- versus pre-treatment changes of brain connectivity, as well as changes in clinical symptoms in the patient group. FM patients reported improvements in symptom severity. Although several brain regions showed a treatment-related change in connectivity, only the connectivity between the right anterior insula and the left primary sensorimotor area was significantly more affected by the physical exercise among the fibromyalgia patients compared to healthy controls. Our results suggest that previously observed aberrant intrinsic brain connectivity patterns in FM are partly normalized by the physical exercise therapy. However, none of the observed normalizations in intrinsic brain connectivity were significantly correlated with symptom changes. Further studies conducted in larger cohorts are warranted to investigate the precise relationship between improvements in fibromyalgia symptoms and changes in intrinsic brain activity.

No MeSH data available.


Related in: MedlinePlus

Average FIQ and SF36BP ratings in 14 FM patients before (solid bars) and following (striped bars) the exercise intervention. The reduction in FIQ ratings indicates reduced FM symptoms. No change was observed in pain ratings (SF36BP). The asterisk sign (*) signifies a significant difference at p < 0.01 between post- versus pre-treatment conditions. Error bars denote standard deviations. FIQ = Fibromyalgia Impact Questionnaire, SF36BP = short form bodily pain subscale.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4556735&req=5

f0005: Average FIQ and SF36BP ratings in 14 FM patients before (solid bars) and following (striped bars) the exercise intervention. The reduction in FIQ ratings indicates reduced FM symptoms. No change was observed in pain ratings (SF36BP). The asterisk sign (*) signifies a significant difference at p < 0.01 between post- versus pre-treatment conditions. Error bars denote standard deviations. FIQ = Fibromyalgia Impact Questionnaire, SF36BP = short form bodily pain subscale.

Mentions: Pre-treatment, the mean SF36BP score for the FM cohort was 37.00 ± 9.70, (highest subjective health, i.e. no pain = 100) whereas the post-treatment score was 37.07 ± 11.40 (t(14) = −0.026, p = 0.98). Further, in the FM cohort, the pre-treatment mean FIQ was 60.8 ± 11.8 (maximally severe FM impact = 100), and for post-training 53.3 ± 29.5 (t(13) = 2.282, p = 0.040, effect size r = 0.53). The FIQ and SF36BP were negatively correlated both pre- (r = −0.78, p = 0.00080) and post-treatment (r = −0.79, p = 0.00089) (Fig. 1).


Normalization of aberrant resting state functional connectivity in fibromyalgia patients following a three month physical exercise therapy.

Flodin P, Martinsen S, Mannerkorpi K, Löfgren M, Bileviciute-Ljungar I, Kosek E, Fransson P - Neuroimage Clin (2015)

Average FIQ and SF36BP ratings in 14 FM patients before (solid bars) and following (striped bars) the exercise intervention. The reduction in FIQ ratings indicates reduced FM symptoms. No change was observed in pain ratings (SF36BP). The asterisk sign (*) signifies a significant difference at p < 0.01 between post- versus pre-treatment conditions. Error bars denote standard deviations. FIQ = Fibromyalgia Impact Questionnaire, SF36BP = short form bodily pain subscale.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4556735&req=5

f0005: Average FIQ and SF36BP ratings in 14 FM patients before (solid bars) and following (striped bars) the exercise intervention. The reduction in FIQ ratings indicates reduced FM symptoms. No change was observed in pain ratings (SF36BP). The asterisk sign (*) signifies a significant difference at p < 0.01 between post- versus pre-treatment conditions. Error bars denote standard deviations. FIQ = Fibromyalgia Impact Questionnaire, SF36BP = short form bodily pain subscale.
Mentions: Pre-treatment, the mean SF36BP score for the FM cohort was 37.00 ± 9.70, (highest subjective health, i.e. no pain = 100) whereas the post-treatment score was 37.07 ± 11.40 (t(14) = −0.026, p = 0.98). Further, in the FM cohort, the pre-treatment mean FIQ was 60.8 ± 11.8 (maximally severe FM impact = 100), and for post-training 53.3 ± 29.5 (t(13) = 2.282, p = 0.040, effect size r = 0.53). The FIQ and SF36BP were negatively correlated both pre- (r = −0.78, p = 0.00080) and post-treatment (r = −0.79, p = 0.00089) (Fig. 1).

Bottom Line: However, little is known about the neurophysiological mechanisms mediating these effects.Our results suggest that previously observed aberrant intrinsic brain connectivity patterns in FM are partly normalized by the physical exercise therapy.However, none of the observed normalizations in intrinsic brain connectivity were significantly correlated with symptom changes.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

ABSTRACT
Physical exercise is one of the most efficient interventions to mitigate chronic pain symptoms in fibromyalgia (FM). However, little is known about the neurophysiological mechanisms mediating these effects. In this study we investigated resting-state connectivity using functional magnetic resonance imaging (fMRI) before and after a 15 week standardized exercise program supervised by physical therapists. Our aim was to gain an understanding of how physical exercise influences previously shown aberrant patterns of intrinsic brain activity in FM. Fourteen FM patients and eleven healthy controls successfully completed the physical exercise treatment. We investigated post- versus pre-treatment changes of brain connectivity, as well as changes in clinical symptoms in the patient group. FM patients reported improvements in symptom severity. Although several brain regions showed a treatment-related change in connectivity, only the connectivity between the right anterior insula and the left primary sensorimotor area was significantly more affected by the physical exercise among the fibromyalgia patients compared to healthy controls. Our results suggest that previously observed aberrant intrinsic brain connectivity patterns in FM are partly normalized by the physical exercise therapy. However, none of the observed normalizations in intrinsic brain connectivity were significantly correlated with symptom changes. Further studies conducted in larger cohorts are warranted to investigate the precise relationship between improvements in fibromyalgia symptoms and changes in intrinsic brain activity.

No MeSH data available.


Related in: MedlinePlus