Limits...
Pre-operative lymphocyte-to-monocyte ratio as a predictor of overall survival in patients suffering from osteosarcoma.

Liu T, Fang XC, Ding Z, Sun ZG, Sun LM, Wang YL - FEBS Open Bio (2015)

Bottom Line: Our results showed that young age, elevated alkaline phosphatase, metastasis at diagnosis, chemotherapy, lymphocyte and monocyte counts were significantly associated with LMR.Low LMR was associated with shorter OS and EFS (P < 0.001), and was an independent predictor of both OS and EFS (HR = 1.72, 95% CI = 1.14-2.60, P = 0.010; HR = 1.89, 95% CI = 1.32-2.57, P = 0.009).A prospective study is warranted for further validation of our results.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedics, The First People's Hospital of Anqing, Anhui 246000, China.

ABSTRACT
Inflammatory markers have been proposed to predict clinical outcomes in many types of cancers. The purpose of this study was to explore the influence of the lymphocyte-to-monocyte ratio (LMR) on clinical prognosis of patients with osteosarcoma. This study collected 327 patients who underwent surgical treatment for osteosarcoma during the period 2006-2010. LMR was calculated from pre-operative peripheral blood cells counts. The optimal cut-off value of LMR was determined based on receiver operating characteristic curve analysis. Overall survival (OS) and event free survival (EFS) was plotted using the Kaplan-Meier method and evaluated by the log-rank test. A predictive model was established to predict clinical prognosis for OS, and the predictive accuracy of this model was determined by concordance index (c-index). Our results showed that young age, elevated alkaline phosphatase, metastasis at diagnosis, chemotherapy, lymphocyte and monocyte counts were significantly associated with LMR. Low LMR was associated with shorter OS and EFS (P < 0.001), and was an independent predictor of both OS and EFS (HR = 1.72, 95% CI = 1.14-2.60, P = 0.010; HR = 1.89, 95% CI = 1.32-2.57, P = 0.009). The nomogram performed well in the prediction of overall survival in patients with osteosarcoma (c-index 0.630). In conclusion, low pre-operative LMR is associated with a poor prognosis in patients suffering from osteosarcoma. A prospective study is warranted for further validation of our results.

No MeSH data available.


Related in: MedlinePlus

Kaplan–Meier curves for survival probability according to LMR levels. (A) Patients with LMR ⩽ 3.43 had a significantly associated with worse overall survival than those with LMR > 3.43; (B) patients with LMR ⩽ 3.43 had a significantly associated with worse event free survival than those with LMR > 3.43.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4556728&req=5

f0010: Kaplan–Meier curves for survival probability according to LMR levels. (A) Patients with LMR ⩽ 3.43 had a significantly associated with worse overall survival than those with LMR > 3.43; (B) patients with LMR ⩽ 3.43 had a significantly associated with worse event free survival than those with LMR > 3.43.

Mentions: The Kaplan–Meier curve showed that the 5-year OS rates of the LLMR group were significantly lower than those of the HLMR group (P < 0.001; Fig. 2A), and similar result was also observed in the 5-year EFS rates (P < 0.001; Fig. 2B). Subsequently, univariate analyses indicated that advanced clinical stage, metastasis at diagnosis, chemotherapy and LLMR were closely correlated with poor prognosis. Furthermore, multivariate analyses of OS and EFS were performed including age, sex and clinical variables with univariate log-rank P < 0.05: advanced clinical stage, metastasis at diagnosis, chemotherapy and LLMR. LLMR, advanced clinical stage and metastasis emerged as markers for shorter OS and EFS (Table 2), and were considered as independent prognostic indicators for patients with osteosarcoma.


Pre-operative lymphocyte-to-monocyte ratio as a predictor of overall survival in patients suffering from osteosarcoma.

Liu T, Fang XC, Ding Z, Sun ZG, Sun LM, Wang YL - FEBS Open Bio (2015)

Kaplan–Meier curves for survival probability according to LMR levels. (A) Patients with LMR ⩽ 3.43 had a significantly associated with worse overall survival than those with LMR > 3.43; (B) patients with LMR ⩽ 3.43 had a significantly associated with worse event free survival than those with LMR > 3.43.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4556728&req=5

f0010: Kaplan–Meier curves for survival probability according to LMR levels. (A) Patients with LMR ⩽ 3.43 had a significantly associated with worse overall survival than those with LMR > 3.43; (B) patients with LMR ⩽ 3.43 had a significantly associated with worse event free survival than those with LMR > 3.43.
Mentions: The Kaplan–Meier curve showed that the 5-year OS rates of the LLMR group were significantly lower than those of the HLMR group (P < 0.001; Fig. 2A), and similar result was also observed in the 5-year EFS rates (P < 0.001; Fig. 2B). Subsequently, univariate analyses indicated that advanced clinical stage, metastasis at diagnosis, chemotherapy and LLMR were closely correlated with poor prognosis. Furthermore, multivariate analyses of OS and EFS were performed including age, sex and clinical variables with univariate log-rank P < 0.05: advanced clinical stage, metastasis at diagnosis, chemotherapy and LLMR. LLMR, advanced clinical stage and metastasis emerged as markers for shorter OS and EFS (Table 2), and were considered as independent prognostic indicators for patients with osteosarcoma.

Bottom Line: Our results showed that young age, elevated alkaline phosphatase, metastasis at diagnosis, chemotherapy, lymphocyte and monocyte counts were significantly associated with LMR.Low LMR was associated with shorter OS and EFS (P < 0.001), and was an independent predictor of both OS and EFS (HR = 1.72, 95% CI = 1.14-2.60, P = 0.010; HR = 1.89, 95% CI = 1.32-2.57, P = 0.009).A prospective study is warranted for further validation of our results.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedics, The First People's Hospital of Anqing, Anhui 246000, China.

ABSTRACT
Inflammatory markers have been proposed to predict clinical outcomes in many types of cancers. The purpose of this study was to explore the influence of the lymphocyte-to-monocyte ratio (LMR) on clinical prognosis of patients with osteosarcoma. This study collected 327 patients who underwent surgical treatment for osteosarcoma during the period 2006-2010. LMR was calculated from pre-operative peripheral blood cells counts. The optimal cut-off value of LMR was determined based on receiver operating characteristic curve analysis. Overall survival (OS) and event free survival (EFS) was plotted using the Kaplan-Meier method and evaluated by the log-rank test. A predictive model was established to predict clinical prognosis for OS, and the predictive accuracy of this model was determined by concordance index (c-index). Our results showed that young age, elevated alkaline phosphatase, metastasis at diagnosis, chemotherapy, lymphocyte and monocyte counts were significantly associated with LMR. Low LMR was associated with shorter OS and EFS (P < 0.001), and was an independent predictor of both OS and EFS (HR = 1.72, 95% CI = 1.14-2.60, P = 0.010; HR = 1.89, 95% CI = 1.32-2.57, P = 0.009). The nomogram performed well in the prediction of overall survival in patients with osteosarcoma (c-index 0.630). In conclusion, low pre-operative LMR is associated with a poor prognosis in patients suffering from osteosarcoma. A prospective study is warranted for further validation of our results.

No MeSH data available.


Related in: MedlinePlus