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Abnormal Resting-State Connectivity at Functional MRI in Women with Premenstrual Syndrome.

Liu Q, Li R, Zhou R, Li J, Gu Q - PLoS ONE (2015)

Bottom Line: The results showed that compared with the control group, the PMS group had decreased connectivity in the middle frontal gyrus (MFG) and theparahippocampalgyrus (PHG), as well as increased connectivity in the left medial/superior temporal gyri (MTG/STG) and precentralgyrus within the default mode network (DMN); in addition, the PMS group had higher anxiety and depression scale scores, together with lower stress perception scores.Finally, there were significantly positive correlations between the stress perception scores and functional connectivity in the MFG and cuneus.These findings suggest that compared with normal women, women with PMS displayed abnormal stress sensitivity, which was reflected in the decreased and increased functional connectivity within the DMN, blunted stress perception and higher depression.

View Article: PubMed Central - PubMed

Affiliation: Beijing Key Laboratory of Applied Experimental Psychology, School of Psychology, Beijing Normal University, Beijing, P. R. China; Research Center of Emotion Regulation, Beijing Normal University, Beijing, P. R. China.

ABSTRACT

Objectives: Premenstrual syndrome (PMS) refers to a series of cycling and relapsing physical, emotion and behavior syndromes that occur in the luteal phase and resolve soon after the onset of menses. Although PMS is widely recognized, its neural mechanism is still unclear.

Design: To address this question, we measured brain activity for women with PMS and women without PMS (control group) using resting-state functional magnetic resonance imaging (rs-fMRI). In addition, the participants should complete the emotion scales (Beck Anxiety Inventory, BAI; Beck Depression Inventory, BDI, before the scanning) as well as the stress perception scale (Visual analog scale for stress, VAS, before and after the scanning).

Results: The results showed that compared with the control group, the PMS group had decreased connectivity in the middle frontal gyrus (MFG) and theparahippocampalgyrus (PHG), as well as increased connectivity in the left medial/superior temporal gyri (MTG/STG) and precentralgyrus within the default mode network (DMN); in addition, the PMS group had higher anxiety and depression scale scores, together with lower stress perception scores. Finally, there were significantly positive correlations between the stress perception scores and functional connectivity in the MFG and cuneus. The BDI scores in the PMS group were correlated negatively with the functional connectivity in the MFG and precuneus and correlated positively with the functional connectivity in the MTG.

Conclusion: These findings suggest that compared with normal women, women with PMS displayed abnormal stress sensitivity, which was reflected in the decreased and increased functional connectivity within the DMN, blunted stress perception and higher depression.

No MeSH data available.


Related in: MedlinePlus

The functional connectivity map of the DMN (default mode network).Axial images show the network for the control (upper panel) and PMS (lower panel) groups. The statistical map was derived from a one-sample t-test of DMN components. The bar at the right shows the T-values. Images are in radiologic format with the left side of the image corresponding to the right side of the subject’s brain.
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pone.0136029.g002: The functional connectivity map of the DMN (default mode network).Axial images show the network for the control (upper panel) and PMS (lower panel) groups. The statistical map was derived from a one-sample t-test of DMN components. The bar at the right shows the T-values. Images are in radiologic format with the left side of the image corresponding to the right side of the subject’s brain.

Mentions: Fig 2 shows the functional connectivity map of the DMN extracted from the Group ICA. The regions displaying significant functional connectivity in both groups mainly cover the medial prefrontal cortex, middle frontal gyrus (MFG), precentralgyrus, precuneus/posteriorcingulate cortex, (para)hippocampal gyrus, superior/inferior parietal lobule, and the superior/middle/inferior temporal gyrus.


Abnormal Resting-State Connectivity at Functional MRI in Women with Premenstrual Syndrome.

Liu Q, Li R, Zhou R, Li J, Gu Q - PLoS ONE (2015)

The functional connectivity map of the DMN (default mode network).Axial images show the network for the control (upper panel) and PMS (lower panel) groups. The statistical map was derived from a one-sample t-test of DMN components. The bar at the right shows the T-values. Images are in radiologic format with the left side of the image corresponding to the right side of the subject’s brain.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4556707&req=5

pone.0136029.g002: The functional connectivity map of the DMN (default mode network).Axial images show the network for the control (upper panel) and PMS (lower panel) groups. The statistical map was derived from a one-sample t-test of DMN components. The bar at the right shows the T-values. Images are in radiologic format with the left side of the image corresponding to the right side of the subject’s brain.
Mentions: Fig 2 shows the functional connectivity map of the DMN extracted from the Group ICA. The regions displaying significant functional connectivity in both groups mainly cover the medial prefrontal cortex, middle frontal gyrus (MFG), precentralgyrus, precuneus/posteriorcingulate cortex, (para)hippocampal gyrus, superior/inferior parietal lobule, and the superior/middle/inferior temporal gyrus.

Bottom Line: The results showed that compared with the control group, the PMS group had decreased connectivity in the middle frontal gyrus (MFG) and theparahippocampalgyrus (PHG), as well as increased connectivity in the left medial/superior temporal gyri (MTG/STG) and precentralgyrus within the default mode network (DMN); in addition, the PMS group had higher anxiety and depression scale scores, together with lower stress perception scores.Finally, there were significantly positive correlations between the stress perception scores and functional connectivity in the MFG and cuneus.These findings suggest that compared with normal women, women with PMS displayed abnormal stress sensitivity, which was reflected in the decreased and increased functional connectivity within the DMN, blunted stress perception and higher depression.

View Article: PubMed Central - PubMed

Affiliation: Beijing Key Laboratory of Applied Experimental Psychology, School of Psychology, Beijing Normal University, Beijing, P. R. China; Research Center of Emotion Regulation, Beijing Normal University, Beijing, P. R. China.

ABSTRACT

Objectives: Premenstrual syndrome (PMS) refers to a series of cycling and relapsing physical, emotion and behavior syndromes that occur in the luteal phase and resolve soon after the onset of menses. Although PMS is widely recognized, its neural mechanism is still unclear.

Design: To address this question, we measured brain activity for women with PMS and women without PMS (control group) using resting-state functional magnetic resonance imaging (rs-fMRI). In addition, the participants should complete the emotion scales (Beck Anxiety Inventory, BAI; Beck Depression Inventory, BDI, before the scanning) as well as the stress perception scale (Visual analog scale for stress, VAS, before and after the scanning).

Results: The results showed that compared with the control group, the PMS group had decreased connectivity in the middle frontal gyrus (MFG) and theparahippocampalgyrus (PHG), as well as increased connectivity in the left medial/superior temporal gyri (MTG/STG) and precentralgyrus within the default mode network (DMN); in addition, the PMS group had higher anxiety and depression scale scores, together with lower stress perception scores. Finally, there were significantly positive correlations between the stress perception scores and functional connectivity in the MFG and cuneus. The BDI scores in the PMS group were correlated negatively with the functional connectivity in the MFG and precuneus and correlated positively with the functional connectivity in the MTG.

Conclusion: These findings suggest that compared with normal women, women with PMS displayed abnormal stress sensitivity, which was reflected in the decreased and increased functional connectivity within the DMN, blunted stress perception and higher depression.

No MeSH data available.


Related in: MedlinePlus