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Changes of Functional Brain Networks in Major Depressive Disorder: A Graph Theoretical Analysis of Resting-State fMRI.

Ye M, Yang T, Qing P, Lei X, Qiu J, Liu G - PLoS ONE (2015)

Bottom Line: Our results showed that compared with healthy controls, MDD patients showed higher local efficiency and modularity.Furthermore, MDD patients showed altered nodal centralities of many brain regions, including hippocampus, temporal cortex, anterior cingulate gyrus and dorsolateral prefrontal gyrus, mainly located in default mode network and cognitive control network.Together, our results suggested that MDD was associated with disruptions in the topological structure of functional brain networks, and provided new insights concerning the pathophysiological mechanisms of MDD.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Computer and Information Science, Southwest University, Chongqing, China; College of Electronic and Information Engineering, Southwest University, Chongqing, China.

ABSTRACT
Recent developments in graph theory have heightened the need for investigating the disruptions in the topological structure of functional brain network in major depressive disorder (MDD). In this study, we employed resting-state functional magnetic resonance imaging (fMRI) and graph theory to examine the whole-brain functional networks among 42 MDD patients and 42 healthy controls. Our results showed that compared with healthy controls, MDD patients showed higher local efficiency and modularity. Furthermore, MDD patients showed altered nodal centralities of many brain regions, including hippocampus, temporal cortex, anterior cingulate gyrus and dorsolateral prefrontal gyrus, mainly located in default mode network and cognitive control network. Together, our results suggested that MDD was associated with disruptions in the topological structure of functional brain networks, and provided new insights concerning the pathophysiological mechanisms of MDD.

No MeSH data available.


Related in: MedlinePlus

Regions exhibited significant between-group differences in regional nodal parameters.The blue color represented the higher values of regional nodal centralities in healthy controls, and the red color represented the higher values of regional nodal centralities in MDD patients (p<0.05, FDR corrected).
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pone.0133775.g004: Regions exhibited significant between-group differences in regional nodal parameters.The blue color represented the higher values of regional nodal centralities in healthy controls, and the red color represented the higher values of regional nodal centralities in MDD patients (p<0.05, FDR corrected).

Mentions: Significant differences were found on nearly the same nodes (Fig 4, Table 2), except for right gyrus rectus and right thalamus whose nodal betweenness showed no significant differences between MDD patients and healthy controls (p<0.05, FDR corrected). Specifically, MDD patients revealed increased nodal centralities in many brain areas, including right gyrus rectus, right hippocampus, bilateral amygdala, right fusiform gyrus, bilateral middle temporal gyrus, and bilateral thalamus compared with healthy controls. Additionally, decreased nodal centralities in MDD patients were observed in bilateral dorsolateral prefrontal gyrus and bilateral anterior cingulate gyrus.


Changes of Functional Brain Networks in Major Depressive Disorder: A Graph Theoretical Analysis of Resting-State fMRI.

Ye M, Yang T, Qing P, Lei X, Qiu J, Liu G - PLoS ONE (2015)

Regions exhibited significant between-group differences in regional nodal parameters.The blue color represented the higher values of regional nodal centralities in healthy controls, and the red color represented the higher values of regional nodal centralities in MDD patients (p<0.05, FDR corrected).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4556670&req=5

pone.0133775.g004: Regions exhibited significant between-group differences in regional nodal parameters.The blue color represented the higher values of regional nodal centralities in healthy controls, and the red color represented the higher values of regional nodal centralities in MDD patients (p<0.05, FDR corrected).
Mentions: Significant differences were found on nearly the same nodes (Fig 4, Table 2), except for right gyrus rectus and right thalamus whose nodal betweenness showed no significant differences between MDD patients and healthy controls (p<0.05, FDR corrected). Specifically, MDD patients revealed increased nodal centralities in many brain areas, including right gyrus rectus, right hippocampus, bilateral amygdala, right fusiform gyrus, bilateral middle temporal gyrus, and bilateral thalamus compared with healthy controls. Additionally, decreased nodal centralities in MDD patients were observed in bilateral dorsolateral prefrontal gyrus and bilateral anterior cingulate gyrus.

Bottom Line: Our results showed that compared with healthy controls, MDD patients showed higher local efficiency and modularity.Furthermore, MDD patients showed altered nodal centralities of many brain regions, including hippocampus, temporal cortex, anterior cingulate gyrus and dorsolateral prefrontal gyrus, mainly located in default mode network and cognitive control network.Together, our results suggested that MDD was associated with disruptions in the topological structure of functional brain networks, and provided new insights concerning the pathophysiological mechanisms of MDD.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Computer and Information Science, Southwest University, Chongqing, China; College of Electronic and Information Engineering, Southwest University, Chongqing, China.

ABSTRACT
Recent developments in graph theory have heightened the need for investigating the disruptions in the topological structure of functional brain network in major depressive disorder (MDD). In this study, we employed resting-state functional magnetic resonance imaging (fMRI) and graph theory to examine the whole-brain functional networks among 42 MDD patients and 42 healthy controls. Our results showed that compared with healthy controls, MDD patients showed higher local efficiency and modularity. Furthermore, MDD patients showed altered nodal centralities of many brain regions, including hippocampus, temporal cortex, anterior cingulate gyrus and dorsolateral prefrontal gyrus, mainly located in default mode network and cognitive control network. Together, our results suggested that MDD was associated with disruptions in the topological structure of functional brain networks, and provided new insights concerning the pathophysiological mechanisms of MDD.

No MeSH data available.


Related in: MedlinePlus