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Serotype-Specific Transmission and Waning Immunity of Endemic Foot-and-Mouth Disease Virus in Cameroon.

Pomeroy LW, Bjørnstad ON, Kim H, Jumbo SD, Abdoulkadiri S, Garabed R - PLoS ONE (2015)

Bottom Line: For serotypes SAT2, SAT3, and type A, a model assuming life-long immunity fit better.They also show that immunity wanes at rates specific to each serotype, which influences patterns of local persistence.Overall, this work shows that viral serotypes can differ significantly in their epidemiological and immunological characteristics.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Preventive Medicine, Ohio State University, Columbus, OH, United States of America.

ABSTRACT
Foot-and-mouth disease virus (FMDV) causes morbidity and mortality in a range of animals and threatens local economies by acting as a barrier to international trade. The outbreak in the United Kingdom in 2001 that cost billions to control highlighted the risk that the pathogen poses to agriculture. In response, several mathematical models have been developed to parameterize and predict both transmission dynamics and optimal disease control. However, a lack of understanding of the multi-strain etiology prevents characterization of multi-strain dynamics. Here, we use data from FMDV serology in an endemic setting to probe strain-specific transmission and immunodynamics. Five serotypes of FMDV affect cattle in the Far North Region of Cameroon. We fit both catalytic and reverse catalytic models to serological data to estimate the force of infection and the rate of waning immunity, and to detect periods of sustained transmission. For serotypes SAT2, SAT3, and type A, a model assuming life-long immunity fit better. For serotypes SAT1 and type O, the better-fit model suggests that immunity may wane over time. Our analysis further indicates that type O has the greatest force of infection and the longest duration of immunity. Estimates for the force of infection were time-varying and indicated that serotypes SAT1 and O displayed endemic dynamics, serotype A displayed epidemic dynamics, and SAT2 and SAT3 did not sustain local chains of transmission. Since these results were obtained from the same population at the same time, they highlight important differences in transmission specific to each serotype. They also show that immunity wanes at rates specific to each serotype, which influences patterns of local persistence. Overall, this work shows that viral serotypes can differ significantly in their epidemiological and immunological characteristics. Patterns and processes that drive transmission in endemic settings must consider complex viral dynamics for accurate representation and interpretation.

No MeSH data available.


Related in: MedlinePlus

Age distribution of sampled cattle.Four hundred sixty nine cattle, ranging in age from one year old to sixteen years old, were sampled for serotype-specific FMDV antibodies.
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pone.0136642.g001: Age distribution of sampled cattle.Four hundred sixty nine cattle, ranging in age from one year old to sixteen years old, were sampled for serotype-specific FMDV antibodies.

Mentions: Sampled animals ranged in age from one-year-old to sixteen-years-old with a mean of 7.8 years (Fig 1). Ages of animals sampled were similar to previous demographic surveys of cattle in the Far North Region [32]; however, the oldest animals in our study were two years older than the oldest animals previously recorded.


Serotype-Specific Transmission and Waning Immunity of Endemic Foot-and-Mouth Disease Virus in Cameroon.

Pomeroy LW, Bjørnstad ON, Kim H, Jumbo SD, Abdoulkadiri S, Garabed R - PLoS ONE (2015)

Age distribution of sampled cattle.Four hundred sixty nine cattle, ranging in age from one year old to sixteen years old, were sampled for serotype-specific FMDV antibodies.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4556668&req=5

pone.0136642.g001: Age distribution of sampled cattle.Four hundred sixty nine cattle, ranging in age from one year old to sixteen years old, were sampled for serotype-specific FMDV antibodies.
Mentions: Sampled animals ranged in age from one-year-old to sixteen-years-old with a mean of 7.8 years (Fig 1). Ages of animals sampled were similar to previous demographic surveys of cattle in the Far North Region [32]; however, the oldest animals in our study were two years older than the oldest animals previously recorded.

Bottom Line: For serotypes SAT2, SAT3, and type A, a model assuming life-long immunity fit better.They also show that immunity wanes at rates specific to each serotype, which influences patterns of local persistence.Overall, this work shows that viral serotypes can differ significantly in their epidemiological and immunological characteristics.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Preventive Medicine, Ohio State University, Columbus, OH, United States of America.

ABSTRACT
Foot-and-mouth disease virus (FMDV) causes morbidity and mortality in a range of animals and threatens local economies by acting as a barrier to international trade. The outbreak in the United Kingdom in 2001 that cost billions to control highlighted the risk that the pathogen poses to agriculture. In response, several mathematical models have been developed to parameterize and predict both transmission dynamics and optimal disease control. However, a lack of understanding of the multi-strain etiology prevents characterization of multi-strain dynamics. Here, we use data from FMDV serology in an endemic setting to probe strain-specific transmission and immunodynamics. Five serotypes of FMDV affect cattle in the Far North Region of Cameroon. We fit both catalytic and reverse catalytic models to serological data to estimate the force of infection and the rate of waning immunity, and to detect periods of sustained transmission. For serotypes SAT2, SAT3, and type A, a model assuming life-long immunity fit better. For serotypes SAT1 and type O, the better-fit model suggests that immunity may wane over time. Our analysis further indicates that type O has the greatest force of infection and the longest duration of immunity. Estimates for the force of infection were time-varying and indicated that serotypes SAT1 and O displayed endemic dynamics, serotype A displayed epidemic dynamics, and SAT2 and SAT3 did not sustain local chains of transmission. Since these results were obtained from the same population at the same time, they highlight important differences in transmission specific to each serotype. They also show that immunity wanes at rates specific to each serotype, which influences patterns of local persistence. Overall, this work shows that viral serotypes can differ significantly in their epidemiological and immunological characteristics. Patterns and processes that drive transmission in endemic settings must consider complex viral dynamics for accurate representation and interpretation.

No MeSH data available.


Related in: MedlinePlus