Correction: Phosphatidylcholine Specific PLC-Induced Dysregulation of Gap Junctions, a Robust Cellular Response to Environmental Toxicants, and Prevention by Resveratrol in a Rat Liver Cell Model.
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pone.0137599.g004: Dysregulation of GJIC through signaling pathways other than MEK1/2 or PC-PLC.The following compounds inhibited GJIC neither through MEK1/2 nor PC-PLC: PFOSA (40 μM, 20 min), BzOOH (200 μM, 15 min), AA (70–100 μM, 15 min), Lau (150 μM, 10 min), BGA (30 μμM, 15 min), PCP (50 μM, 10 min) and Alachlor (185 μM, 25 min). The cells were treated with inhibitors of PC-PLC (D609, 50 μM, 20 min) or MEK1/2 (U0126, 20 μM, 30 min), or resveratrol (100 μM, 15 min) before addition of GJIC-dysregulator. At least three independent experiments were averaged ± SD. An ANOVA was conducted for each GJIC-dysregulator followed by a Dunnett’s post-hoc test to determine significance (at P<0.05 as indicated by an *) from cells treated with only the GJIC-dysregulator. The F-values for PFOSA, BzOOH, AA, Lau, BGA, PCP and alachlor were 1.0 (P = 0.426), 0.6 (P = 0.628), 0.7 (P = 0.565), 0.6 (P = 0.617), 2.1 (P = 0.131), 1.9 (P = 0.162) and 58.6 (P<0.001), respectively.
Figs 2, 3, 4, and 5 are each missing an internal color legend. The authors have provided a corrected version of each figure here.