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Correction: Phosphatidylcholine Specific PLC-Induced Dysregulation of Gap Junctions, a Robust Cellular Response to Environmental Toxicants, and Prevention by Resveratrol in a Rat Liver Cell Model.

Raza FA, Ur Rehman S, Khalid R, Ahmad J, Ashraf S, Iqbal M, Hasnain S - PLoS ONE (2015)

View Article: PubMed Central - PubMed

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Related in: MedlinePlus

Dysregulation of GJIC through PC-PLC.The following compounds inhibited GJIC through PC-PLC: (a) Through the following PAHs: Flu (100 μM, 10 min), 1-MeFlu (70 μM, 10 min), Phe (70 μM, 10 min), 1-MeA (70 μM, 10 min), 9,10-DiMeA (100 μM, 10 min), Fla (70 μM, 10 min), Pyr (70 μM, 10 min) and 1-MePyr (70 μM, 10 min); (b) Other toxicants: PFDA (50 μM, 20 min), DiCuOOH (50 μM, 15 min), PCB 153 (50 μM, 30 min), and DDT (30 μM, 20 min). The cells were treated with inhibitors of PC-PLC (D609, 50 μM, 20 min) or MEK1/2 (U0126, 20 μM, 30 min), or resveratrol (100 μM, 15 min) before addition of GJIC-dysregulator. At least three independent experiments were averaged ± SD. An ANOVA was conducted for each GJIC-dysregulator followed by a Dunnett’s post-hoc test to determine significance (at P<0.05 as indicated by an *) from cells treated with only the GJIC-dysregulator. The F-values for Flu, 1-MeFlu, Phe, 1-MeA, 9,10-DiMeA, Fla, Pyr and 1-MeP were 71.8 (P<0.001), 75.6 (P<0.001), 57.7 (P<0.001), 737.3 (P<0.001), 74.2 (P<0.001), 58.4 (P<0.001), 67.4 (P<0.001) and 50.5 (P<0.001), respectively. The F-values for PFDA, DiCuOOH, PCB 153, and DDT were 13.1 (P = 0.002), 51.2 (P<0.001), 38.3 (P<0.001) and 87.5 (P<0.001), respectively.
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pone.0137599.g001: Dysregulation of GJIC through PC-PLC.The following compounds inhibited GJIC through PC-PLC: (a) Through the following PAHs: Flu (100 μM, 10 min), 1-MeFlu (70 μM, 10 min), Phe (70 μM, 10 min), 1-MeA (70 μM, 10 min), 9,10-DiMeA (100 μM, 10 min), Fla (70 μM, 10 min), Pyr (70 μM, 10 min) and 1-MePyr (70 μM, 10 min); (b) Other toxicants: PFDA (50 μM, 20 min), DiCuOOH (50 μM, 15 min), PCB 153 (50 μM, 30 min), and DDT (30 μM, 20 min). The cells were treated with inhibitors of PC-PLC (D609, 50 μM, 20 min) or MEK1/2 (U0126, 20 μM, 30 min), or resveratrol (100 μM, 15 min) before addition of GJIC-dysregulator. At least three independent experiments were averaged ± SD. An ANOVA was conducted for each GJIC-dysregulator followed by a Dunnett’s post-hoc test to determine significance (at P<0.05 as indicated by an *) from cells treated with only the GJIC-dysregulator. The F-values for Flu, 1-MeFlu, Phe, 1-MeA, 9,10-DiMeA, Fla, Pyr and 1-MeP were 71.8 (P<0.001), 75.6 (P<0.001), 57.7 (P<0.001), 737.3 (P<0.001), 74.2 (P<0.001), 58.4 (P<0.001), 67.4 (P<0.001) and 50.5 (P<0.001), respectively. The F-values for PFDA, DiCuOOH, PCB 153, and DDT were 13.1 (P = 0.002), 51.2 (P<0.001), 38.3 (P<0.001) and 87.5 (P<0.001), respectively.

Mentions: Figs 2, 3, 4, and 5 are each missing an internal color legend. The authors have provided a corrected version of each figure here.


Correction: Phosphatidylcholine Specific PLC-Induced Dysregulation of Gap Junctions, a Robust Cellular Response to Environmental Toxicants, and Prevention by Resveratrol in a Rat Liver Cell Model.

Raza FA, Ur Rehman S, Khalid R, Ahmad J, Ashraf S, Iqbal M, Hasnain S - PLoS ONE (2015)

Dysregulation of GJIC through PC-PLC.The following compounds inhibited GJIC through PC-PLC: (a) Through the following PAHs: Flu (100 μM, 10 min), 1-MeFlu (70 μM, 10 min), Phe (70 μM, 10 min), 1-MeA (70 μM, 10 min), 9,10-DiMeA (100 μM, 10 min), Fla (70 μM, 10 min), Pyr (70 μM, 10 min) and 1-MePyr (70 μM, 10 min); (b) Other toxicants: PFDA (50 μM, 20 min), DiCuOOH (50 μM, 15 min), PCB 153 (50 μM, 30 min), and DDT (30 μM, 20 min). The cells were treated with inhibitors of PC-PLC (D609, 50 μM, 20 min) or MEK1/2 (U0126, 20 μM, 30 min), or resveratrol (100 μM, 15 min) before addition of GJIC-dysregulator. At least three independent experiments were averaged ± SD. An ANOVA was conducted for each GJIC-dysregulator followed by a Dunnett’s post-hoc test to determine significance (at P<0.05 as indicated by an *) from cells treated with only the GJIC-dysregulator. The F-values for Flu, 1-MeFlu, Phe, 1-MeA, 9,10-DiMeA, Fla, Pyr and 1-MeP were 71.8 (P<0.001), 75.6 (P<0.001), 57.7 (P<0.001), 737.3 (P<0.001), 74.2 (P<0.001), 58.4 (P<0.001), 67.4 (P<0.001) and 50.5 (P<0.001), respectively. The F-values for PFDA, DiCuOOH, PCB 153, and DDT were 13.1 (P = 0.002), 51.2 (P<0.001), 38.3 (P<0.001) and 87.5 (P<0.001), respectively.
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Related In: Results  -  Collection

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pone.0137599.g001: Dysregulation of GJIC through PC-PLC.The following compounds inhibited GJIC through PC-PLC: (a) Through the following PAHs: Flu (100 μM, 10 min), 1-MeFlu (70 μM, 10 min), Phe (70 μM, 10 min), 1-MeA (70 μM, 10 min), 9,10-DiMeA (100 μM, 10 min), Fla (70 μM, 10 min), Pyr (70 μM, 10 min) and 1-MePyr (70 μM, 10 min); (b) Other toxicants: PFDA (50 μM, 20 min), DiCuOOH (50 μM, 15 min), PCB 153 (50 μM, 30 min), and DDT (30 μM, 20 min). The cells were treated with inhibitors of PC-PLC (D609, 50 μM, 20 min) or MEK1/2 (U0126, 20 μM, 30 min), or resveratrol (100 μM, 15 min) before addition of GJIC-dysregulator. At least three independent experiments were averaged ± SD. An ANOVA was conducted for each GJIC-dysregulator followed by a Dunnett’s post-hoc test to determine significance (at P<0.05 as indicated by an *) from cells treated with only the GJIC-dysregulator. The F-values for Flu, 1-MeFlu, Phe, 1-MeA, 9,10-DiMeA, Fla, Pyr and 1-MeP were 71.8 (P<0.001), 75.6 (P<0.001), 57.7 (P<0.001), 737.3 (P<0.001), 74.2 (P<0.001), 58.4 (P<0.001), 67.4 (P<0.001) and 50.5 (P<0.001), respectively. The F-values for PFDA, DiCuOOH, PCB 153, and DDT were 13.1 (P = 0.002), 51.2 (P<0.001), 38.3 (P<0.001) and 87.5 (P<0.001), respectively.
Mentions: Figs 2, 3, 4, and 5 are each missing an internal color legend. The authors have provided a corrected version of each figure here.

View Article: PubMed Central - PubMed

No MeSH data available.


Related in: MedlinePlus