53BP1 suppresses epithelial-mesenchymal transition by downregulating ZEB1 through microRNA-200b/429 in breast cancer.
Bottom Line: Consistently, in MCF-7 breast cancer cells, low 53BP1 expression reduced E-cadherin expression, resulting in increased migration and invasion.These effects were reversed by miR-200b and miR-429 inhibition or overexpression.It was also found that 53BP1 was associated with lymph node metastasis.
Affiliation: Department of Breast Surgery, Qilu Hospital, Shandong University, Jinan, China.Show MeSH
Related in: MedlinePlus
Mentions: Furthermore, treatments with miR-200b/429 inhibitors and mimics reversed the effects of 53BP1 on migration and invasion in MDA-MB-231-53BP1 cells and MCF-7-sh53BP1 cells (Fig.4), indicating that miR-200b/429 mediated 53BP1’s negative regulation of migration and invasion.
Affiliation: Department of Breast Surgery, Qilu Hospital, Shandong University, Jinan, China.