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Navigation Strategies of Motor Proteins on Decorated Tracks.

Bertalan Z, Budrikis Z, La Porta CA, Zapperi S - PLoS ONE (2015)

Bottom Line: Here, we show by numerical simulations that deterministic and random motor steps yield different outcomes when random obstacles decorate the microtubule tracks: kinesin moves faster on clean tracks but its motion is strongly hindered on decorated tracks, while dynein is slower on clean tracks but more efficient in avoiding obstacles.Further simulations indicate that dynein's advantage on decorated tracks is due to its ability to step backwards.Our results explain how different navigation strategies are employed by the cell to optimize motor driven cargo transport.

View Article: PubMed Central - PubMed

Affiliation: Institute for Scientific Interchange Foundation, Torino, Italy.

ABSTRACT
Motor proteins display widely different stepping patterns as they move on microtubule tracks, from the deterministic linear or helical motion performed by the protein kinesin to the uncoordinated random steps made by dynein. How these different strategies produce an efficient navigation system needed to ensure correct cellular functioning is still unclear. Here, we show by numerical simulations that deterministic and random motor steps yield different outcomes when random obstacles decorate the microtubule tracks: kinesin moves faster on clean tracks but its motion is strongly hindered on decorated tracks, while dynein is slower on clean tracks but more efficient in avoiding obstacles. Further simulations indicate that dynein's advantage on decorated tracks is due to its ability to step backwards. Our results explain how different navigation strategies are employed by the cell to optimize motor driven cargo transport.

No MeSH data available.


Related in: MedlinePlus

Velocity distributions are normal on undecorated tracks but develop a peak around v = 0 as decoration fraction ρ is increased.A: Kinesin, whose velocity can only be positive. B: For dynein, the distribution includes also negative velocities. Lines are guides to the eye; errorbars are smaller than the symbol size.
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pone.0136945.g005: Velocity distributions are normal on undecorated tracks but develop a peak around v = 0 as decoration fraction ρ is increased.A: Kinesin, whose velocity can only be positive. B: For dynein, the distribution includes also negative velocities. Lines are guides to the eye; errorbars are smaller than the symbol size.

Mentions: Beyond the mean velocity, our simulations also yield information about the distribution of instantaneous velocities v, whose distributions are reported in Fig 5. At zero decoration fraction, the velocities of dynein and kinesin have a normal distribution about their mean value. However, on decorated tracks the distributions become bimodal and develop peaks around v = 0, which increase in weight as the decoration fraction increases, reflecting the increasing difficulty of navigation.


Navigation Strategies of Motor Proteins on Decorated Tracks.

Bertalan Z, Budrikis Z, La Porta CA, Zapperi S - PLoS ONE (2015)

Velocity distributions are normal on undecorated tracks but develop a peak around v = 0 as decoration fraction ρ is increased.A: Kinesin, whose velocity can only be positive. B: For dynein, the distribution includes also negative velocities. Lines are guides to the eye; errorbars are smaller than the symbol size.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4556374&req=5

pone.0136945.g005: Velocity distributions are normal on undecorated tracks but develop a peak around v = 0 as decoration fraction ρ is increased.A: Kinesin, whose velocity can only be positive. B: For dynein, the distribution includes also negative velocities. Lines are guides to the eye; errorbars are smaller than the symbol size.
Mentions: Beyond the mean velocity, our simulations also yield information about the distribution of instantaneous velocities v, whose distributions are reported in Fig 5. At zero decoration fraction, the velocities of dynein and kinesin have a normal distribution about their mean value. However, on decorated tracks the distributions become bimodal and develop peaks around v = 0, which increase in weight as the decoration fraction increases, reflecting the increasing difficulty of navigation.

Bottom Line: Here, we show by numerical simulations that deterministic and random motor steps yield different outcomes when random obstacles decorate the microtubule tracks: kinesin moves faster on clean tracks but its motion is strongly hindered on decorated tracks, while dynein is slower on clean tracks but more efficient in avoiding obstacles.Further simulations indicate that dynein's advantage on decorated tracks is due to its ability to step backwards.Our results explain how different navigation strategies are employed by the cell to optimize motor driven cargo transport.

View Article: PubMed Central - PubMed

Affiliation: Institute for Scientific Interchange Foundation, Torino, Italy.

ABSTRACT
Motor proteins display widely different stepping patterns as they move on microtubule tracks, from the deterministic linear or helical motion performed by the protein kinesin to the uncoordinated random steps made by dynein. How these different strategies produce an efficient navigation system needed to ensure correct cellular functioning is still unclear. Here, we show by numerical simulations that deterministic and random motor steps yield different outcomes when random obstacles decorate the microtubule tracks: kinesin moves faster on clean tracks but its motion is strongly hindered on decorated tracks, while dynein is slower on clean tracks but more efficient in avoiding obstacles. Further simulations indicate that dynein's advantage on decorated tracks is due to its ability to step backwards. Our results explain how different navigation strategies are employed by the cell to optimize motor driven cargo transport.

No MeSH data available.


Related in: MedlinePlus