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Parkinson's Disease Prevalence and Proximity to Agricultural Cultivated Fields.

Yitshak Sade M, Zlotnik Y, Kloog I, Novack V, Peretz C, Ifergane G - Parkinsons Dis (2015)

Bottom Line: Highest SIR was observed in localities located in proximity to large ACF (SIR 1.54, 95% CI 1.32; 1.79).In conclusion, in this population based study we found that PD SIRs were higher than expected in rural localities.Furthermore, it appears that proximity to ACF and the field size contribute to PD risk.

View Article: PubMed Central - PubMed

Affiliation: Clinical Research Center, Soroka University Medical Center, 84101 Beer Sheva, Israel ; Faculty of Health Sciences, Ben Gurion University, 84101 Beer Sheva, Israel.

ABSTRACT
The risk for developing Parkinson's disease (PD) is a combination of multiple environmental and genetic factors. The Negev (Southern Israel) contains approximately 252.5 km(2) of agricultural cultivated fields (ACF). We aimed to estimate the prevalence and incidence of PD and to examine possible geographical clustering and associations with agricultural exposures. We screened all "Clalit" Health Services members in the Negev (70% of the population) between the years 2000 and 2012. Individual demographic, clinical, and medication prescription data were available. We used a refined medication tracer algorithm to identify PD patients. We used mixed Poisson models to calculate the smoothed standardized incidence rates (SIRs) for each locality. We identified ACF and calculate the size and distance of the fields from each locality. We identified 3,792 cases of PD. SIRs were higher than expected in Jewish rural localities (median SIR [95% CI]: 1.41 [1.28; 1.53] in 2001-2004, 1.62 [1.48; 1.76] in 2005-2008, and 1.57 [1.44; 1.80] in 2009-2012). Highest SIR was observed in localities located in proximity to large ACF (SIR 1.54, 95% CI 1.32; 1.79). In conclusion, in this population based study we found that PD SIRs were higher than expected in rural localities. Furthermore, it appears that proximity to ACF and the field size contribute to PD risk.

No MeSH data available.


Related in: MedlinePlus

The figure shows the age and gender adjusted standardized incidence rates (SIRs) of Parkinson's disease in localities in Southern Israel. The full lines represent the borders of the southern district in Israel. The graduated symbols represent the SIR in each locality. Agricultural cultivated fields are highlighted in the map.
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fig2: The figure shows the age and gender adjusted standardized incidence rates (SIRs) of Parkinson's disease in localities in Southern Israel. The full lines represent the borders of the southern district in Israel. The graduated symbols represent the SIR in each locality. Agricultural cultivated fields are highlighted in the map.

Mentions: Figure 2 shows a significant variation in SIR between different localities in the Negev. Median rates were higher than expected in Jewish rural localities, where the median values (and 95% CI) ranged between 1.41 (1.28; 1.53) and 1.62 (1.48–1.76). Among Bedouin localities, both temporary and permanent, SIR was lower than expected (Table 3).


Parkinson's Disease Prevalence and Proximity to Agricultural Cultivated Fields.

Yitshak Sade M, Zlotnik Y, Kloog I, Novack V, Peretz C, Ifergane G - Parkinsons Dis (2015)

The figure shows the age and gender adjusted standardized incidence rates (SIRs) of Parkinson's disease in localities in Southern Israel. The full lines represent the borders of the southern district in Israel. The graduated symbols represent the SIR in each locality. Agricultural cultivated fields are highlighted in the map.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4556329&req=5

fig2: The figure shows the age and gender adjusted standardized incidence rates (SIRs) of Parkinson's disease in localities in Southern Israel. The full lines represent the borders of the southern district in Israel. The graduated symbols represent the SIR in each locality. Agricultural cultivated fields are highlighted in the map.
Mentions: Figure 2 shows a significant variation in SIR between different localities in the Negev. Median rates were higher than expected in Jewish rural localities, where the median values (and 95% CI) ranged between 1.41 (1.28; 1.53) and 1.62 (1.48–1.76). Among Bedouin localities, both temporary and permanent, SIR was lower than expected (Table 3).

Bottom Line: Highest SIR was observed in localities located in proximity to large ACF (SIR 1.54, 95% CI 1.32; 1.79).In conclusion, in this population based study we found that PD SIRs were higher than expected in rural localities.Furthermore, it appears that proximity to ACF and the field size contribute to PD risk.

View Article: PubMed Central - PubMed

Affiliation: Clinical Research Center, Soroka University Medical Center, 84101 Beer Sheva, Israel ; Faculty of Health Sciences, Ben Gurion University, 84101 Beer Sheva, Israel.

ABSTRACT
The risk for developing Parkinson's disease (PD) is a combination of multiple environmental and genetic factors. The Negev (Southern Israel) contains approximately 252.5 km(2) of agricultural cultivated fields (ACF). We aimed to estimate the prevalence and incidence of PD and to examine possible geographical clustering and associations with agricultural exposures. We screened all "Clalit" Health Services members in the Negev (70% of the population) between the years 2000 and 2012. Individual demographic, clinical, and medication prescription data were available. We used a refined medication tracer algorithm to identify PD patients. We used mixed Poisson models to calculate the smoothed standardized incidence rates (SIRs) for each locality. We identified ACF and calculate the size and distance of the fields from each locality. We identified 3,792 cases of PD. SIRs were higher than expected in Jewish rural localities (median SIR [95% CI]: 1.41 [1.28; 1.53] in 2001-2004, 1.62 [1.48; 1.76] in 2005-2008, and 1.57 [1.44; 1.80] in 2009-2012). Highest SIR was observed in localities located in proximity to large ACF (SIR 1.54, 95% CI 1.32; 1.79). In conclusion, in this population based study we found that PD SIRs were higher than expected in rural localities. Furthermore, it appears that proximity to ACF and the field size contribute to PD risk.

No MeSH data available.


Related in: MedlinePlus