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Spherulitic copper-copper oxide nanostructure-based highly sensitive nonenzymatic glucose sensor.

Das G, Tran TQ, Yoon HH - Int J Nanomedicine (2015)

Bottom Line: In addition, this electrode was found to be resistant to interference by common interfering agents such as urea, cystamine, L-ascorbic acid, and creatinine.The high performance of the Cu-CuO spherulites with nanowire-to-nanorod outgrowths was primarily due to the high surface area and stability, and good three-dimensional structure.Furthermore, the ITO/MWCNT/Cu-CuOB electrode applied to real urine and serum sample showed satisfactory performance.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical and Biological Engineering, Gachon University, Seongnam, Republic of South Korea.

ABSTRACT
In this work, three different spherulitic nanostructures Cu-CuOA, Cu-CuOB, and Cu-CuOC were synthesized in water-in-oil microemulsions by varying the surfactant concentration (30 mM, 40 mM, and 50 mM, respectively). The structural and morphological characteristics of the Cu-CuO nanostructures were investigated by ultraviolet-visible (UV-vis) spectroscopy, X-ray diffraction, scanning electron microscopy, and high-resolution transmission electron microscopy techniques. The synthesized nanostructures were deposited on multiwalled carbon nanotube (MWCNT)-modified indium tin oxide (ITO) electrodes to fabricate a nonenzymatic highly sensitive amperometric glucose sensor. The performance of the ITO/MWCNT/Cu-CuO electrodes in the glucose assay was examined by cyclic voltammetry and chronoamperometric studies. The sensitivity of the sensor varied with the spherulite type; Cu-CuOA, Cu-CuOB, and Cu-CuOC exhibited a sensitivity of 1,229, 3,012, and 3,642 µA mM(-1)·cm(-2), respectively. Moreover, the linear range is dependent on the structure types: 0.023-0.29 mM, 0.07-0.8 mM, and 0.023-0.34 mM for Cu-CuOA, Cu-CuOB, and Cu-CuOC, respectively. An excellent response time of 3 seconds and a low detection limit of 2 µM were observed for Cu-CuOB at an applied potential of +0.34 V. In addition, this electrode was found to be resistant to interference by common interfering agents such as urea, cystamine, L-ascorbic acid, and creatinine. The high performance of the Cu-CuO spherulites with nanowire-to-nanorod outgrowths was primarily due to the high surface area and stability, and good three-dimensional structure. Furthermore, the ITO/MWCNT/Cu-CuOB electrode applied to real urine and serum sample showed satisfactory performance.

No MeSH data available.


Related in: MedlinePlus

Transmission electron microscopy micrographs.Notes: (A–C) Cu–CuOB. (D) Lattice fringe pattern of Cu–CuO.
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f3-ijn-10-165: Transmission electron microscopy micrographs.Notes: (A–C) Cu–CuOB. (D) Lattice fringe pattern of Cu–CuO.

Mentions: The spherulitic nanostructure of Cu–CuO was also observed by high-resolution transmission electron microscope. Figure 3 shows that radially arrayed outgrowths of 15–20 nm in diameter originate from the central core. The spherulitic structures are porous with large surface areas. Figure 3D reveals the polycrystalline nature of the nanostructures as the lattice fringe patterns have different orientations. The interplanar spacings were measured to be 0.17 nm and 0.23 nm, which correspond to Cu (111) and CuO (200), respectively.34


Spherulitic copper-copper oxide nanostructure-based highly sensitive nonenzymatic glucose sensor.

Das G, Tran TQ, Yoon HH - Int J Nanomedicine (2015)

Transmission electron microscopy micrographs.Notes: (A–C) Cu–CuOB. (D) Lattice fringe pattern of Cu–CuO.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4556295&req=5

f3-ijn-10-165: Transmission electron microscopy micrographs.Notes: (A–C) Cu–CuOB. (D) Lattice fringe pattern of Cu–CuO.
Mentions: The spherulitic nanostructure of Cu–CuO was also observed by high-resolution transmission electron microscope. Figure 3 shows that radially arrayed outgrowths of 15–20 nm in diameter originate from the central core. The spherulitic structures are porous with large surface areas. Figure 3D reveals the polycrystalline nature of the nanostructures as the lattice fringe patterns have different orientations. The interplanar spacings were measured to be 0.17 nm and 0.23 nm, which correspond to Cu (111) and CuO (200), respectively.34

Bottom Line: In addition, this electrode was found to be resistant to interference by common interfering agents such as urea, cystamine, L-ascorbic acid, and creatinine.The high performance of the Cu-CuO spherulites with nanowire-to-nanorod outgrowths was primarily due to the high surface area and stability, and good three-dimensional structure.Furthermore, the ITO/MWCNT/Cu-CuOB electrode applied to real urine and serum sample showed satisfactory performance.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical and Biological Engineering, Gachon University, Seongnam, Republic of South Korea.

ABSTRACT
In this work, three different spherulitic nanostructures Cu-CuOA, Cu-CuOB, and Cu-CuOC were synthesized in water-in-oil microemulsions by varying the surfactant concentration (30 mM, 40 mM, and 50 mM, respectively). The structural and morphological characteristics of the Cu-CuO nanostructures were investigated by ultraviolet-visible (UV-vis) spectroscopy, X-ray diffraction, scanning electron microscopy, and high-resolution transmission electron microscopy techniques. The synthesized nanostructures were deposited on multiwalled carbon nanotube (MWCNT)-modified indium tin oxide (ITO) electrodes to fabricate a nonenzymatic highly sensitive amperometric glucose sensor. The performance of the ITO/MWCNT/Cu-CuO electrodes in the glucose assay was examined by cyclic voltammetry and chronoamperometric studies. The sensitivity of the sensor varied with the spherulite type; Cu-CuOA, Cu-CuOB, and Cu-CuOC exhibited a sensitivity of 1,229, 3,012, and 3,642 µA mM(-1)·cm(-2), respectively. Moreover, the linear range is dependent on the structure types: 0.023-0.29 mM, 0.07-0.8 mM, and 0.023-0.34 mM for Cu-CuOA, Cu-CuOB, and Cu-CuOC, respectively. An excellent response time of 3 seconds and a low detection limit of 2 µM were observed for Cu-CuOB at an applied potential of +0.34 V. In addition, this electrode was found to be resistant to interference by common interfering agents such as urea, cystamine, L-ascorbic acid, and creatinine. The high performance of the Cu-CuO spherulites with nanowire-to-nanorod outgrowths was primarily due to the high surface area and stability, and good three-dimensional structure. Furthermore, the ITO/MWCNT/Cu-CuOB electrode applied to real urine and serum sample showed satisfactory performance.

No MeSH data available.


Related in: MedlinePlus