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Serum 25-hydroxyvitamin D predicts cognitive performance in adults.

Darwish H, Zeinoun P, Ghusn H, Khoury B, Tamim H, Khoury SJ - Neuropsychiatr Dis Treat (2015)

Bottom Line: Lebanon has a high 25-hydroxyvitamin D (25(OH)D) deficiency prevalence across all age groups.Participants were screened for depression prior to cognitive screening using the Montreal Cognitive Assessment Arabic version.Prospective longitudinal studies are needed to ascertain the effect of such interventions.

View Article: PubMed Central - PubMed

Affiliation: Hariri School of Nursing, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.

ABSTRACT

Background: Vitamin D is an endogenous hormone known to regulate calcium levels in the body and plays a role in cognitive performance. Studies have shown an association between vitamin D deficiency and cognitive impairment in older adults. Lebanon has a high 25-hydroxyvitamin D (25(OH)D) deficiency prevalence across all age groups.

Methods: In this cross-sectional study, we explored the cognitive performance and serum 25(OH)D levels using an electrochemoluminescent immunoassay in 254 older (>60 years) as well as younger (30-60 years) adults. Subjects' characteristics, including age, years of education, wearing of veil, alcohol consumption, smoking, and physical exercise, were collected. Participants were screened for depression prior to cognitive screening using the Montreal Cognitive Assessment Arabic version. Visuospatial memory was tested using the Rey Complex Figure Test and Recognition Trial, and speed of processing was assessed using the Symbol Digit Modalities test.

Results: Pearson's correlation and stepwise linear regression analyses showed that a low vitamin D level was associated with greater risk of cognitive impairment in older as well as younger adults.

Conclusion: These findings suggest that correction of vitamin D needs to be explored as an intervention to prevent cognitive impairment. Prospective longitudinal studies are needed to ascertain the effect of such interventions.

No MeSH data available.


Related in: MedlinePlus

Sample characteristics: years of education.
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f1-ndt-11-2217: Sample characteristics: years of education.

Mentions: Of the 254, 61.8% were adults aged 30–60 years old (with mean ± standard deviation of 44.31±8.72 years) and 38.2% were older than 60 years old (71.26±0.77 years). Their mean HSCL-25 anxiety and depression scores were 1.49±0.40 and 1.80±0.52 respectively. The majority were female (68.9%), among whom 83.1% did not wear a veil. The majority (67%) had received 12 or more years of education (Figure 1). Approximately 26% were smoking at the time of the study, and 40% were ever smokers, while 26.7% drank a moderate amount of alcohol. The majority (76.4%) had low 25(OH)D <30 ng/mL (25.50±12.67 ng/dL). The mean 25(OH)D level in veiled women (n=41) was lower than that in the rest (n=134) of the sample (16.02±7.73 ng/dL vs 27.11±14.15 ng/dL) (P<0.0001). The difference in 25(OH)D level between males and females was not statistically significant (21.25±9.59 ng/dL vs 24.51±13.75 ng/dL, respectively) (P=0.057) (Table 1).


Serum 25-hydroxyvitamin D predicts cognitive performance in adults.

Darwish H, Zeinoun P, Ghusn H, Khoury B, Tamim H, Khoury SJ - Neuropsychiatr Dis Treat (2015)

Sample characteristics: years of education.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4556248&req=5

f1-ndt-11-2217: Sample characteristics: years of education.
Mentions: Of the 254, 61.8% were adults aged 30–60 years old (with mean ± standard deviation of 44.31±8.72 years) and 38.2% were older than 60 years old (71.26±0.77 years). Their mean HSCL-25 anxiety and depression scores were 1.49±0.40 and 1.80±0.52 respectively. The majority were female (68.9%), among whom 83.1% did not wear a veil. The majority (67%) had received 12 or more years of education (Figure 1). Approximately 26% were smoking at the time of the study, and 40% were ever smokers, while 26.7% drank a moderate amount of alcohol. The majority (76.4%) had low 25(OH)D <30 ng/mL (25.50±12.67 ng/dL). The mean 25(OH)D level in veiled women (n=41) was lower than that in the rest (n=134) of the sample (16.02±7.73 ng/dL vs 27.11±14.15 ng/dL) (P<0.0001). The difference in 25(OH)D level between males and females was not statistically significant (21.25±9.59 ng/dL vs 24.51±13.75 ng/dL, respectively) (P=0.057) (Table 1).

Bottom Line: Lebanon has a high 25-hydroxyvitamin D (25(OH)D) deficiency prevalence across all age groups.Participants were screened for depression prior to cognitive screening using the Montreal Cognitive Assessment Arabic version.Prospective longitudinal studies are needed to ascertain the effect of such interventions.

View Article: PubMed Central - PubMed

Affiliation: Hariri School of Nursing, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.

ABSTRACT

Background: Vitamin D is an endogenous hormone known to regulate calcium levels in the body and plays a role in cognitive performance. Studies have shown an association between vitamin D deficiency and cognitive impairment in older adults. Lebanon has a high 25-hydroxyvitamin D (25(OH)D) deficiency prevalence across all age groups.

Methods: In this cross-sectional study, we explored the cognitive performance and serum 25(OH)D levels using an electrochemoluminescent immunoassay in 254 older (>60 years) as well as younger (30-60 years) adults. Subjects' characteristics, including age, years of education, wearing of veil, alcohol consumption, smoking, and physical exercise, were collected. Participants were screened for depression prior to cognitive screening using the Montreal Cognitive Assessment Arabic version. Visuospatial memory was tested using the Rey Complex Figure Test and Recognition Trial, and speed of processing was assessed using the Symbol Digit Modalities test.

Results: Pearson's correlation and stepwise linear regression analyses showed that a low vitamin D level was associated with greater risk of cognitive impairment in older as well as younger adults.

Conclusion: These findings suggest that correction of vitamin D needs to be explored as an intervention to prevent cognitive impairment. Prospective longitudinal studies are needed to ascertain the effect of such interventions.

No MeSH data available.


Related in: MedlinePlus