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Gastroprotective Activities of Sennoside A and Sennoside B via the Up-Regulation of Prostaglandin E2 and the Inhibition of H(+)/K(+)-ATPase.

Hwang IY, Jeong CS - Biomol Ther (Seoul) (2015)

Bottom Line: It was observed that both sennoside A and sennoside B increased prostaglandin E2 (PGE2) levels and inhibited H(+)/K(+)-ATPase (proton pump).Furthermore, sennoside A and B increased PGE2 in a concentration-dependent manner.Our results thus suggest that sennoside A and sennoside B possess significant gastroprotective activities and they might be useful for the treatment of gastric disease.

View Article: PubMed Central - PubMed

Affiliation: College of Pharmacy, Duksung Women's University, Seoul 132-714, Republic of Korea.

ABSTRACT
Sennoside A (erythro) and sennoside B (threo) are dianthrone glycosides and diastereomers. We investigated their abilities to prevent the gastric lesions associated with diseases, such as, gastritis and gastric ulcer. To elucidate their gastroprotective effects, the inhibitions of HCl•EtOH-induced gastritis and indomethacin-induced gastric ulcers were assessed in rats. It was observed that both sennoside A and sennoside B increased prostaglandin E2 (PGE2) levels and inhibited H(+)/K(+)-ATPase (proton pump). In a rat model, both compounds reduced gastric juice, total acidity and increased pH, indicating that proton pump inhibition reduces gastric acid secretion. Furthermore, sennoside A and B increased PGE2 in a concentration-dependent manner. In a gastric emptying and intestinal transporting rate experiment, both sennoside A and sennoside B accelerated motility. Our results thus suggest that sennoside A and sennoside B possess significant gastroprotective activities and they might be useful for the treatment of gastric disease.

No MeSH data available.


Related in: MedlinePlus

Effects of sennoside A and sennoside B on gastric secretion in pylorus-ligated rats. The values are mean ± S.E.M. of 6 animals. Significant difference *p<0.05; **p<0.01; ***p<0.001 compared to the control group.
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f6-bt-23-458: Effects of sennoside A and sennoside B on gastric secretion in pylorus-ligated rats. The values are mean ± S.E.M. of 6 animals. Significant difference *p<0.05; **p<0.01; ***p<0.001 compared to the control group.

Mentions: We measured gastric secretion parameters, such as, volume of gastric-juice and its pH, after submitting rats to pylorus ligature after administering or not administering sennoside A or B intraduodenally (Fig. 6). The volume of gastric secretion by sennoside B was approximately 4.0 mL, which was less than the 7.0 mL of the control, and sennoside A showed a similar volume of 4.4. Sennoside A and sennoside B increased gastric-juice pH to 1.7, as compared to the 1.4 of the control, and reduced total acid output to 0.4 mEq/4hrs and 0.3 mEq/4hrs, respectively, as compared with 0.7 mEq/4hrs for the control. Accordingly, sennoside A and B were found to inhibit the volume of gastric-juice, increase pH, and decrease total acid output, it was expected to suppress the aggressive factor through the reduction of gastric secretion.


Gastroprotective Activities of Sennoside A and Sennoside B via the Up-Regulation of Prostaglandin E2 and the Inhibition of H(+)/K(+)-ATPase.

Hwang IY, Jeong CS - Biomol Ther (Seoul) (2015)

Effects of sennoside A and sennoside B on gastric secretion in pylorus-ligated rats. The values are mean ± S.E.M. of 6 animals. Significant difference *p<0.05; **p<0.01; ***p<0.001 compared to the control group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4556206&req=5

f6-bt-23-458: Effects of sennoside A and sennoside B on gastric secretion in pylorus-ligated rats. The values are mean ± S.E.M. of 6 animals. Significant difference *p<0.05; **p<0.01; ***p<0.001 compared to the control group.
Mentions: We measured gastric secretion parameters, such as, volume of gastric-juice and its pH, after submitting rats to pylorus ligature after administering or not administering sennoside A or B intraduodenally (Fig. 6). The volume of gastric secretion by sennoside B was approximately 4.0 mL, which was less than the 7.0 mL of the control, and sennoside A showed a similar volume of 4.4. Sennoside A and sennoside B increased gastric-juice pH to 1.7, as compared to the 1.4 of the control, and reduced total acid output to 0.4 mEq/4hrs and 0.3 mEq/4hrs, respectively, as compared with 0.7 mEq/4hrs for the control. Accordingly, sennoside A and B were found to inhibit the volume of gastric-juice, increase pH, and decrease total acid output, it was expected to suppress the aggressive factor through the reduction of gastric secretion.

Bottom Line: It was observed that both sennoside A and sennoside B increased prostaglandin E2 (PGE2) levels and inhibited H(+)/K(+)-ATPase (proton pump).Furthermore, sennoside A and B increased PGE2 in a concentration-dependent manner.Our results thus suggest that sennoside A and sennoside B possess significant gastroprotective activities and they might be useful for the treatment of gastric disease.

View Article: PubMed Central - PubMed

Affiliation: College of Pharmacy, Duksung Women's University, Seoul 132-714, Republic of Korea.

ABSTRACT
Sennoside A (erythro) and sennoside B (threo) are dianthrone glycosides and diastereomers. We investigated their abilities to prevent the gastric lesions associated with diseases, such as, gastritis and gastric ulcer. To elucidate their gastroprotective effects, the inhibitions of HCl•EtOH-induced gastritis and indomethacin-induced gastric ulcers were assessed in rats. It was observed that both sennoside A and sennoside B increased prostaglandin E2 (PGE2) levels and inhibited H(+)/K(+)-ATPase (proton pump). In a rat model, both compounds reduced gastric juice, total acidity and increased pH, indicating that proton pump inhibition reduces gastric acid secretion. Furthermore, sennoside A and B increased PGE2 in a concentration-dependent manner. In a gastric emptying and intestinal transporting rate experiment, both sennoside A and sennoside B accelerated motility. Our results thus suggest that sennoside A and sennoside B possess significant gastroprotective activities and they might be useful for the treatment of gastric disease.

No MeSH data available.


Related in: MedlinePlus